alx-0600 and Colitis

alx-0600 has been researched along with Colitis* in 1 studies

Other Studies

1 other study(ies) available for alx-0600 and Colitis

Article	Year
Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models. Journal of medicinal chemistry, 2018, 04-12, Volume: 61, Issue:7 Glucagon-like peptide 2 (GLP-2) is a hormone that has been shown to stimulate intestinal growth and attenuate intestinal inflammation. Despite being efficacious in a variety of animal models of disease, its therapeutic potential is hampered by the short half-life in vivo. We now describe a highly potent, stapled long-acting GLP-2 analog, peptide 10, that has a more than 10-fold longer half-life than teduglutide and improved intestinotrophic and anti-inflammatory effects in mouse models of DSS-induced colitis. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cross-Linking Reagents; Cyclic AMP; Dextran Sulfate; Drug Design; Female; Gastrointestinal Agents; Glucagon-Like Peptide 2; Half-Life; Intestines; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Conformation; Peptides	2018

Article

Year

Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models.

Journal of medicinal chemistry, 2018, 04-12, Volume: 61, Issue:7

Glucagon-like peptide 2 (GLP-2) is a hormone that has been shown to stimulate intestinal growth and attenuate intestinal inflammation. Despite being efficacious in a variety of animal models of disease, its therapeutic potential is hampered by the short half-life in vivo. We now describe a highly potent, stapled long-acting GLP-2 analog, peptide 10, that has a more than 10-fold longer half-life than teduglutide and improved intestinotrophic and anti-inflammatory effects in mouse models of DSS-induced colitis.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cross-Linking Reagents; Cyclic AMP; Dextran Sulfate; Drug Design; Female; Gastrointestinal Agents; Glucagon-Like Peptide 2; Half-Life; Intestines; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Conformation; Peptides

2018