alx-0600 and Bacteremia

In children, short-bowel syndrome (SBS) accounts for two-thirds of the cases of intestinal failure, and motility disorders and congenital mucosal diarrheal disorders account for the remaining one-third. Children with SBS are supported primarily by parenteral nutrition, which is the single-most important therapy contributing to their improved prognosis. More than 90% of children with SBS who are cared for at experienced intestinal rehabilitation programs survive, and roughly 60% to 70% undergo intestinal adaptation and achieve full enteral autonomy. This article focuses on the predictors of pediatric intestinal adaptation and discusses the pathophysiology and clinical management of children with SBS.

Topics: Adaptation, Physiological; Bacteremia; Biomarkers; Catheterization, Central Venous; Child; Citrulline; Enteral Nutrition; Gastrointestinal Agents; Humans; Liver Diseases; Parenteral Nutrition; Peptides; Prognosis; Short Bowel Syndrome