alverine has been researched along with Muscle Contraction in 1 studies
alverine : A tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel syndrome.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alverine may increase Ca influx during action potentials due to inhibition of the inactivation of L-type Ca channels, but may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+." | 1.34 | Evolving mechanisms of action of alverine citrate on phasic smooth muscles. ( Brading, AF; Hashitani, H; Hayase, M; Kohri, K; Suzuki, H, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayase, M | 1 |
| Hashitani, H | 1 |
| Suzuki, H | 1 |
| Kohri, K | 1 |
| Brading, AF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION Trial): Protocol of a Multicentre Randomized Controlled Clinical Trial[NCT05100719] | 200 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for alverine and Muscle Contraction
| Article | Year |
|---|---|
Evolving mechanisms of action of alverine citrate on phasic smooth muscles.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Gui | 2007 |