alverine has been researched along with Irritable Bowel Syndrome in 6 studies
alverine : A tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel syndrome.
Irritable Bowel Syndrome: A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of alverine citrate and simeticone combination in patients with IBS-related abdominal pain/discomfort." | 9.14 | Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study. ( Andro Delestrain, MC; Bueno, L; Ducrotté, P; Paradowski, L; Wittmann, T, 2010) |
| "To evaluate the efficacy of alverine citrate and simeticone combination in patients with IBS-related abdominal pain/discomfort." | 5.14 | Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study. ( Andro Delestrain, MC; Bueno, L; Ducrotté, P; Paradowski, L; Wittmann, T, 2010) |
| "Alverine, an antispasmodic agent for the treatment of irritable bowel syndrome (IBS), may be combined with simethicone, a protective agent of the mucosa." | 3.79 | Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association. ( Andro-Delestrain, MC; Beaufrand, C; Bueno, L; Theodorou, V, 2013) |
| "Alverine citrate is one of the most commonly used antispasmodic drugs for patients with irritable bowel syndrome." | 3.76 | [A case report of alverine-citrate-induced acute hepatitis]. ( Chon, U; Han, JY; Jeong, S; Joo, K; Kim, JM; Kim, YS; Lee, DH; Lee, JI; Lee, JW; Min, KS, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bueno, L | 2 |
| Beaufrand, C | 1 |
| Theodorou, V | 1 |
| Andro-Delestrain, MC | 2 |
| Ducrotte, P | 2 |
| Grimaud, JC | 1 |
| Dapoigny, M | 1 |
| Personnic, S | 1 |
| O'Mahony, V | 1 |
| Wittmann, T | 1 |
| Paradowski, L | 1 |
| Andro Delestrain, MC | 1 |
| Han, JY | 1 |
| Lee, JW | 1 |
| Kim, JM | 1 |
| Joo, K | 1 |
| Chon, U | 1 |
| Lee, JI | 1 |
| Jeong, S | 1 |
| Lee, DH | 1 |
| Kim, YS | 1 |
| Min, KS | 1 |
| Ford, AC | 1 |
| Makarchuk, PA | 1 |
| Golovenko, OV | 1 |
| Mikhaĭlova, TL | 1 |
| Podmarenkova, LF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of On-demand MeteoSpasmyl® Use Effectiveness in Irritable Bowel Syndrome[NCT01404923] | Phase 4 | 436 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION Trial): Protocol of a Multicentre Randomized Controlled Clinical Trial[NCT05100719] | 200 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Irritable Bowel Syndrome Quality of Life total score (IBSQoL) is a health-related Quality of Life (QoL) disease-specific scale adapted for French patients. Total score ranges from minimum=0 to maximum = 100 representing the best outcome. (NCT01404923)
Timeframe: Baseline and 6 months
| Intervention | units on a scale (Mean) |
|---|---|
| Meteospasmyl | 13.8 |
| Standard of Care | 8.4 |
Improvement of the total IBSQoL scores from baseline to month 6 calculated in percentage (NCT01404923)
Timeframe: Baseline and 6 Months
| Intervention | % of improvement of IBSQoL total scores (Mean) |
|---|---|
| Meteospasmyl | 28.5 |
| Standard of Care | 18.6 |
3 trials available for alverine and Irritable Bowel Syndrome
| Article | Year |
|---|---|
On-demand treatment with alverine citrate/simeticone compared with standard treatments for irritable bowel syndrome: results of a randomised pragmatic study.
Topics: Abdominal Pain; Antifoaming Agents; Double-Blind Method; Drug Combinations; Female; Humans; Irritabl | 2014 |
On-demand treatment with alverine citrate/simeticone compared with standard treatments for irritable bowel syndrome: results of a randomised pragmatic study.
Topics: Abdominal Pain; Antifoaming Agents; Double-Blind Method; Drug Combinations; Female; Humans; Irritabl | 2014 |
On-demand treatment with alverine citrate/simeticone compared with standard treatments for irritable bowel syndrome: results of a randomised pragmatic study.
Topics: Abdominal Pain; Antifoaming Agents; Double-Blind Method; Drug Combinations; Female; Humans; Irritabl | 2014 |
On-demand treatment with alverine citrate/simeticone compared with standard treatments for irritable bowel syndrome: results of a randomised pragmatic study.
Topics: Abdominal Pain; Antifoaming Agents; Double-Blind Method; Drug Combinations; Female; Humans; Irritabl | 2014 |
Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study.
Topics: Abdominal Pain; Adolescent; Adult; Aged; Antifoaming Agents; Double-Blind Method; Drug Combinations; | 2010 |
[Dynamics of clinical symptoms and indices of visceral sensitivity in patients with the irritated bowels syndrome treated with meteospasmyl].
Topics: Adult; Drug Combinations; Female; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Pain; Pain Th | 2005 |
3 other studies available for alverine and Irritable Bowel Syndrome
| Article | Year |
|---|---|
Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association.
Topics: Animals; Antifoaming Agents; Colic; Colon; Dilatation, Pathologic; Disease Models, Animal; Disease R | 2013 |
[A case report of alverine-citrate-induced acute hepatitis].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Citrates; Female; Humans; Irritable Bow | 2010 |
Alverine citrate, simeticone, and Rome III irritable bowel syndrome.
Topics: Abdominal Pain; Antifoaming Agents; Drug Therapy, Combination; Humans; Irritable Bowel Syndrome; Met | 2010 |