Page last updated: 2024-08-22

aluminum sulfate and Diabetes Mellitus, Type 1

aluminum sulfate has been researched along with Diabetes Mellitus, Type 1 in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.57)29.6817
2010's16 (57.14)24.3611
2020's11 (39.29)2.80

Authors

AuthorsStudies
Achenbach, P; Barcenilla, H; Casas, R; Dietrich, F; Ludvigsson, J; Tavira, B; Wahlberg, J1
Achenbach, P; Barcenilla, H; Casas, R; Dietrich, F; Ludvigsson, J; Puente-Marin, S; Tavira, B; Wahlberg, J1
Hannelius, U; Ludvigsson, J; Nowak, C1
Casas, R; Clemente-León, M; Dietrich, F; Ferrer Lozano, M; Gómez-Gila, A; Hanas, R; Hannelius, U; Hernandez, C; Lind, M; Ludvigsson, J; Lundberg, E; Martínez-Brocca, MA; Nattero-Chavez, L; Nowak, C; Pelikanova, T; Pruhova, S; Puente-Marin, S; Rica, I; Ruiz de Adana, M; Sas, T; Sumnik, Z; Wahlberg, J1
Fiorina, P; Lunati, ME1
Björklund, A; Grill, V; Hals, IK; Ludvigsson, J1
Bruggeman, Y; Ellis, D; Gysemans, C; Laureys, J; Martens, PJ; Mathieu, C; Teyton, L; Viaene, M1
Choat, HM; Lunsford, AA; Martin, A; McCormick, KL; McGwin, GG; Mick, GJ; Tse, HM1
Achenbach, P; Barcenilla, H; Casas, R; Dietrich, F; Ludvigsson, J; Puente-Marin, S1
Balasuriya, C; Björklund, A; Casas, R; Grill, V; Hals, IK; Ludvigsson, J1
Albin, AK; Arvidsson, CG; Carlsson, A; Casas, R; Hanås, R; Ludvigsson, J; Rathsman, B; Routray, I; Samuelsson, U; Särnblad, S; Vigård, T1
Åkerman, L; Axelsson, S; Casas, R; Cheramy, M; Ludvigsson, J; Tavira, B1
Ludvigsson, J2
Peakman, M; Yeo, L1
Achenbach, P; Barcenilla, H; Casas, R; Ludvigsson, J; Tavira, B; Wahlberg, J1
Akerman, L; Axelsson, S; Casas, R; Chéramy, M; Hjorth, M; Ludvigsson, J; Mallone, R; Pihl, M1
Akerman, L; Axelsson, S; Casas, R; Chéramy, M; Ludvigsson, J; Pihl, M2
Achenbach, P; Agardh, CD; Bonifacio, E; Furmaniak, J; Hansen, JM; Hausmann, S; Krause, S; Landherr, U; Lernmark, A; Link, K; Lynch, KF; Powell, M; Rees-Smith, B; Ziegler, AG1
Chen, Z; Dang, H; Kaufman, DL; Nguyen, AV; Tian, J1
Hinke, SA1
Casas, R; Chéramy, M; Hampe, CS; Johansson, I; Ludvigsson, J; Skoglund, C1
Akerman, L; Axelsson, S; Casas, R; Hjorth, M; Ludvigsson, J1
Axelsson, S; Casas, R; Faresjö, M; Hjorth, M; Ludvigsson, J; Rydén, A1
Larsson, HE; Lernmark, A1
Casas, R; Chéramy, M; Hampe, CS; Ludvigsson, J; Skoglund, C1
Casas, R; Chéramy, M; Hampe, CS; Ludvigsson, J1

Reviews

5 review(s) available for aluminum sulfate and Diabetes Mellitus, Type 1

ArticleYear
Association between treatment effect on C-peptide preservation and HbA1c in meta-analysis of glutamic acid decarboxylase (GAD)-alum immunotherapy in recent-onset type 1 diabetes.
    Diabetes, obesity & metabolism, 2022, Volume: 24, Issue:8

    Topics: Alum Compounds; Autoantibodies; C-Peptide; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Glycated Hemoglobin; Humans; Immunologic Factors; Immunotherapy

2022
GAD65: a prospective vaccine for treating Type 1 diabetes?
    Expert opinion on biological therapy, 2017, Volume: 17, Issue:8

    Topics: Adaptive Immunity; Alum Compounds; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Vaccination

2017
Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes.
    Current opinion in molecular therapeutics, 2008, Volume: 10, Issue:5

    Topics: Adjuvants, Immunologic; Adult; Alum Compounds; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Humans; Injections, Subcutaneous; Recombinant Proteins

2008
GAD-alum (Diamyd)--a new concept for preservation of residual insulin secretion.
    Expert opinion on biological therapy, 2010, Volume: 10, Issue:5

    Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Alum Compounds; Animals; Child; Child, Preschool; Diabetes Mellitus, Type 1; Evidence-Based Medicine; Glutamate Decarboxylase; Humans; Immune Tolerance; Immunotherapy; Insulin; Insulin Secretion; Insulin-Secreting Cells; Middle Aged; Recombinant Proteins; Treatment Outcome; Young Adult

2010
Does immune-tolerance treatment with Alum-formulated GAD65 protect insulin-production in the pancreatic islet β cells?
    Human vaccines, 2011, Jan-01, Volume: 7, Issue:1

    Topics: Adjuvants, Immunologic; Alum Compounds; Autoimmune Diseases; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Humans; Immune Tolerance; Immunization, Secondary; Injections, Subcutaneous; Vaccination

2011

Trials

15 trial(s) available for aluminum sulfate and Diabetes Mellitus, Type 1

ArticleYear
Intra-lymphatic administration of GAD-alum in type 1 diabetes: long-term follow-up and effect of a late booster dose (the DIAGNODE Extension trial).
    Acta diabetologica, 2022, Volume: 59, Issue:5

    Topics: Alum Compounds; Autoantibodies; C-Peptide; Diabetes Mellitus, Type 1; Follow-Up Studies; Glutamate Decarboxylase; Glycated Hemoglobin; Humans; Immunoglobulin G

2022
Intralymphatic GAD-Alum (Diamyd®) Improves Glycemic Control in Type 1 Diabetes With HLA DR3-DQ2.
    The Journal of clinical endocrinology and metabolism, 2022, 08-18, Volume: 107, Issue:9

    Topics: Adolescent; Alum Compounds; Blood Glucose; Blood Glucose Self-Monitoring; C-Peptide; Child; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Glycemic Control; HLA-DR3 Antigen; Humans; Vitamin D; Young Adult

2022
Latent Autoimmune Diabetes in Adults: Background, Safety and Feasibility of an Ongoing Pilot Study With Intra-Lymphatic Injections of GAD-Alum and Oral Vitamin D.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adult; Aged; Alum Compounds; Diabetes Mellitus, Type 1; Feasibility Studies; Glucose Intolerance; Glutamate Decarboxylase; Humans; Insulin; Latent Autoimmune Diabetes in Adults; Middle Aged; Pilot Projects; Vitamin D

2022
A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine function in children with newly diagnosed type 1 diabetes.
    Nature communications, 2022, 12-24, Volume: 13, Issue:1

    Topics: Animals; Diabetes Mellitus, Type 1; gamma-Aminobutyric Acid; Glucagon; Glutamate Decarboxylase; Islets of Langerhans

2022
Intralymphatic glutamic acid decarboxylase administration in type 1 diabetes patients induced a distinctive early immune response in patients with DR3DQ2 haplotype.
    Frontiers in immunology, 2023, Volume: 14

    Topics: C-Peptide; Cytokines; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Haplotypes; HLA Antigens; Humans; Immunity, Cellular; Interleukin-10; Interleukin-13; Interleukin-5

2023
Effect of simultaneous vaccination with H1N1 and GAD-alum on GAD
    Diabetologia, 2017, Volume: 60, Issue:7

    Topics: Adolescent; Alum Compounds; Autoantibodies; C-Peptide; Child; Cytokines; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Finland; Glutamate Decarboxylase; Hemagglutinins; Humans; Immune System; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Insulin; Insulin Secretion; Male; Normal Distribution; Sweden; Time Factors; Vaccination; Young Adult

2017
Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes.
    Journal of diabetes research, 2018, Volume: 2018

    Topics: Adolescent; Alum Compounds; Cell Proliferation; Child; Cytokines; Diabetes Mellitus, Type 1; Female; Glutamate Decarboxylase; Humans; Immunoglobulin G; Immunomodulation; Immunophenotyping; Leukocytes, Mononuclear; Lymph Nodes; Lymphocyte Activation; Male; Pilot Projects; Th2 Cells; Treatment Outcome; Young Adult

2018
Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes.
    Clinical and experimental immunology, 2013, Volume: 172, Issue:3

    Topics: Adjuvants, Immunologic; Adolescent; Alum Compounds; Autoantigens; Child; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Glutamate Decarboxylase; Humans; Immunosuppression Therapy; Interleukin-2 Receptor alpha Subunit; Interleukin-7 Receptor alpha Subunit; Lymphocyte Activation; Male; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Time Factors; Treatment Outcome

2013
Cellular and humoral immune responses in type 1 diabetic patients participating in a phase III GAD-alum intervention trial.
    Diabetes care, 2013, Volume: 36, Issue:11

    Topics: Adult; Alum Compounds; Autoantibodies; Diabetes Mellitus, Type 1; Female; Glutamate Decarboxylase; Humans; Immunity, Cellular; Immunity, Humoral; Immunoglobulin G; Insulin; Leukocytes, Mononuclear; Male; Middle Aged

2013
GAD-treatment of children and adolescents with recent-onset type 1 diabetes preserves residual insulin secretion after 30 months.
    Diabetes/metabolism research and reviews, 2014, Volume: 30, Issue:5

    Topics: Adolescent; Alum Compounds; Autoantibodies; C-Peptide; Child; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Glutamate Decarboxylase; Glycated Hemoglobin; Humans; Injections, Subcutaneous; Insulin; Insulin Secretion; Male; Young Adult

2014
GAD autoantibody affinity in adult patients with latent autoimmune diabetes, the study participants of a GAD65 vaccination trial.
    Diabetes care, 2014, Volume: 37, Issue:6

    Topics: Adult; Aged; Alum Compounds; Autoantibodies; C-Peptide; Diabetes Mellitus, Type 1; Disease Progression; Double-Blind Method; Female; Glucose Intolerance; Glutamate Decarboxylase; Humans; Insulin-Secreting Cells; Male; Middle Aged; Vaccination; Vaccines, Synthetic

2014
GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response.
    Clinical immunology (Orlando, Fla.), 2010, Volume: 137, Issue:1

    Topics: Adjuvants, Immunologic; Adolescent; Alum Compounds; Antibodies; Area Under Curve; Autoantibodies; Biocatalysis; C-Peptide; Child; Diabetes Mellitus, Type 1; Double-Blind Method; Glutamate Decarboxylase; Humans; Immune Sera; Immunity, Humoral; Immunoglobulin E; Immunoglobulin G; Immunotherapy, Active; Tetanus Toxoid; Treatment Outcome

2010
GAD-alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients.
    Clinical immunology (Orlando, Fla.), 2011, Volume: 138, Issue:1

    Topics: Adolescent; Alum Compounds; Autoantibodies; CD4-Positive T-Lymphocytes; Cell Count; Child; Diabetes Mellitus, Type 1; Female; Forkhead Transcription Factors; Gene Expression; Glutamate Decarboxylase; Humans; Immunosuppression Therapy; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Interleukins; Leukocytes, Mononuclear; Lymphocyte Activation; Male; T-Lymphocytes, Regulatory; Th2 Cells; Transforming Growth Factor beta; Treatment Outcome; Tumor Necrosis Factor-alpha

2011
GAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetes.
    Pediatric diabetes, 2012, Volume: 13, Issue:3

    Topics: Adolescent; Alum Compounds; Autoantibodies; Child; Diabetes Mellitus, Type 1; Epitopes; Glutamate Decarboxylase; Humans

2012
Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals.
    Clinical and experimental immunology, 2013, Volume: 171, Issue:3

    Topics: Adolescent; Adult; Aged; Alum Compounds; Autoantibodies; Diabetes Mellitus, Type 1; Female; Glutamate Decarboxylase; Humans; Immunoglobulin G; Male; Middle Aged; Phenotype; Stiff-Person Syndrome

2013

Other Studies

8 other study(ies) available for aluminum sulfate and Diabetes Mellitus, Type 1

ArticleYear
Immune response differs between intralymphatic or subcutaneous administration of GAD-alum in individuals with recent onset type 1 diabetes.
    Diabetes/metabolism research and reviews, 2022, Volume: 38, Issue:3

    Topics: Alum Compounds; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Humans; Immunity; Leukocytes, Mononuclear

2022
Antigen-based Immunotherapy Improves Glycemic Metrics and β-Cell Function.
    The Journal of clinical endocrinology and metabolism, 2022, 09-28, Volume: 107, Issue:10

    Topics: Alum Compounds; Benchmarking; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 1; Glycemic Control; HLA-DR3 Antigen; Humans; Immunotherapy

2022
Preventing type 1 diabetes in late-stage pre-diabetic NOD mice with insulin: A central role for alum as adjuvant.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Animals; C-Peptide; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 1; Female; Forkhead Transcription Factors; Humans; Infant, Newborn; Insulin; Mice; Mice, Inbred NOD; Mice, Obese; Peptides; Prediabetic State

2022
A 1-year pilot study of intralymphatic injections of GAD-alum in individuals with latent autoimmune diabetes in adults (LADA) with signs of high immunity: No safety concerns and resemblance to juvenile type 1 diabetes.
    Diabetes, obesity & metabolism, 2023, Volume: 25, Issue:11

    Topics: Adult; Autoantibodies; Diabetes Mellitus, Type 1; Glucose Intolerance; Glutamate Decarboxylase; Humans; Injections, Intralymphatic; Latent Autoimmune Diabetes in Adults; Leukocytes, Mononuclear; Middle Aged; Pilot Projects

2023
Combined Etanercept, GAD-alum and vitamin D treatment: an open pilot trial to preserve beta cell function in recent onset type 1 diabetes.
    Diabetes/metabolism research and reviews, 2021, Volume: 37, Issue:7

    Topics: Adolescent; Aged; Alum Compounds; Child; Diabetes Mellitus, Type 1; Etanercept; Female; Glutamate Decarboxylase; Humans; Insulin; Leukocytes, Mononuclear; Male; Pilot Projects; Vitamin D

2021
Antigen-specific immunotherapy and influenza vaccination in type 1 diabetes: timing is everything.
    Diabetologia, 2017, Volume: 60, Issue:7

    Topics: Alum Compounds; Animals; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Humans; Immunotherapy; Influenza Vaccines; Vaccination; Vaccines, Conjugate

2017
Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice.
    Diabetes, 2014, Volume: 63, Issue:9

    Topics: Alum Compounds; Animals; Autoimmunity; Blood Glucose; Cell Division; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Female; Interleukin-10; Interleukin-4; Mice; Mice, Inbred NOD; Proinsulin; T-Lymphocytes, Regulatory

2014
Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65).
    Diabetes/metabolism research and reviews, 2010, Volume: 26, Issue:7

    Topics: Adolescent; Alum Compounds; Autoantibodies; Child; Diabetes Mellitus, Type 1; Follow-Up Studies; Forkhead Transcription Factors; Glutamate Decarboxylase; Humans; Immunologic Factors; Insulin; Interferon-gamma; Interleukins; Monocytes; Multicenter Studies as Topic; Protein Tyrosine Phosphatases; Randomized Controlled Trials as Topic; Th2 Cells; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2010