aluminum-phthalocyanine-disulfonate and Leiomyosarcoma

Photochemical internalization (PCI) is a novel technique for delivery of active macromolecules into cancerous cells, via light activation of a specific photosensitizer and a low dose systemic drug. Numerous pre-clinical studies and one clinical trial have confirmed the treatment potential in carcinomas. Soft tissue sarcomas are rare and generally resistant to radio- and chemotherapy. Due to treatment resistance and surgical morbidity in sarcoma care, we seek to increase knowledge on PCI effects in sarcomas by studying two different, but closely related leiomyosarcomas.. MES-SA and SK-LMS-1 tumours were established in the leg muscles of athymic mice. Treatment effects after AlPcS. PCI of bleomycin induced a similar and significant increase in time to reach the end point in both tumour models, while neither responded to AlPcS. AlPcS2a-based PCI, but not PDT, induced significant tumour growth delay in the evaluated sarcomas. Cellular responsiveness to bleomycin and tumour vascularity are identified as predictive markers for PCI treatment effects.

Topics: Animals; Bleomycin; Cell Line, Tumor; Disease Models, Animal; Female; Genes, p53; Indoles; Lasers, Semiconductor; Leiomyosarcoma; Mice; Mice, Knockout; Mice, Nude; Neovascularization, Pathologic; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents