altretamine has been researched along with Nervous System Diseases in 4 studies
Altretamine: A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic studies (100-500 mg m-2) indicated that PMM plasma levels are dose-dependent and that the PMM disposition-phase half-life is prolonged in patients with abnormal liver function." | 2.65 | Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies. ( Harrap, KR; Muindi, JR; Newell, DR; Smith, IE, 1983) |
| "Ninety-eight patients with metastatic breast cancer, heavily pretreated with other agents, were entered in a phase II trial of hexamethylmelamine (HEX)." | 2.65 | Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study. ( Balcerzak, S; Fabian, CJ; Haut, A; Rasmussen, S; Smith, F; Stephens, R; Tranum, B, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muindi, JR | 1 |
| Newell, DR | 1 |
| Smith, IE | 1 |
| Harrap, KR | 1 |
| Weiss, RB | 1 |
| Fabian, CJ | 1 |
| Rasmussen, S | 1 |
| Stephens, R | 1 |
| Haut, A | 1 |
| Smith, F | 1 |
| Balcerzak, S | 1 |
| Tranum, B | 1 |
| van der Hoop, RG | 1 |
| van der Burg, ME | 1 |
| ten Bokkel Huinink, WW | 1 |
| van Houwelingen, C | 1 |
| Neijt, JP | 1 |
1 review available for altretamine and Nervous System Diseases
| Article | Year |
|---|---|
The role of hexamethylmelamine in advanced ovarian carcinoma treatment.
Topics: Altretamine; Drug Therapy, Combination; Female; Humans; Nervous System Diseases; Ovarian Neoplasms; | 1981 |
3 trials available for altretamine and Nervous System Diseases
| Article | Year |
|---|---|
Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Clinical Trials as Topic; Female; Humans; Kinetics; | 1983 |
Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study.
Topics: Aged; Altretamine; Breast Neoplasms; Drug Evaluation; Female; Humans; Middle Aged; Nausea; Nervous S | 1979 |
Incidence of neuropathy in 395 patients with ovarian cancer treated with or without cisplatin.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubici | 1990 |