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altretamine and Nausea

altretamine has been researched along with Nausea in 18 studies

Altretamine: A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

ExcerptRelevanceReference
"A four-drug combination of intermittent high-dose cyclophosphamide with 5-fluorouracil, hexamethylmelamine, and prednisone was given to 19 patients with advanced breast cancer."7.66Phase I--II evaluation of combination cyclophosphamide, 5-fluorouracil, hexamethylmelamine, and prednisone in advanced breast cancer. ( Chang, YC; Crowley, J; Falkson, G; Tormey, DC, 1981)
"A four-drug combination of intermittent high-dose cyclophosphamide with 5-fluorouracil, hexamethylmelamine, and prednisone was given to 19 patients with advanced breast cancer."3.66Phase I--II evaluation of combination cyclophosphamide, 5-fluorouracil, hexamethylmelamine, and prednisone in advanced breast cancer. ( Chang, YC; Crowley, J; Falkson, G; Tormey, DC, 1981)
" Pharmacokinetic studies (100-500 mg m-2) indicated that PMM plasma levels are dose-dependent and that the PMM disposition-phase half-life is prolonged in patients with abnormal liver function."2.65Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies. ( Harrap, KR; Muindi, JR; Newell, DR; Smith, IE, 1983)
"Ninety-eight patients with metastatic breast cancer, heavily pretreated with other agents, were entered in a phase II trial of hexamethylmelamine (HEX)."2.65Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study. ( Balcerzak, S; Fabian, CJ; Haut, A; Rasmussen, S; Smith, F; Stephens, R; Tranum, B, 1979)
"Eleven patients with metastatic breast cancer refractory to conventional therapy were treated with a combination of hexamethylmelamine 250 mg/m2 p."1.26An evaluation of hexamethylmelamine, cis-diamminedichloroplatinum, and mitomycin-C in advanced breast cancer. A pilot study of the Southeastern Cancer Study Group. ( Lawson, D; Moore, M; Smalley, R, 1980)
"Pentamethylmelamine is a soluble monodemethylated derivative of hexamethylmelamine."1.26Phase I study of pentamethylmelamine. ( Goldberg, RS; Griffin, JP; Krakoff, IH; McSherry, JW, 1980)
"Twenty-one patients with advanced ovarian cancer proven resistant to standard alkylating chemotherapy were evaluated in a prospective study of Hexamethylmelamine."1.26Hexamethylmelamine in alkylating agent-resistant ovarian carcinoma. ( Bender, RA; Chabner, BA; DeVita, VT; Fisher, RI; Johnson, BL; Young, RC, 1978)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199017 (94.44)18.7374
1990's1 (5.56)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Muindi, JR1
Newell, DR1
Smith, IE1
Harrap, KR1
Carmo-Pereira, J1
Costa, FO1
Henriques, E1
Gad-el-Mawla, N2
Ziegler, JL1
Hamza, R1
Elserafi, M1
Khaled, H2
Macdonald, JS1
Lawson, D1
Moore, M1
Smalley, R1
Freedman, RS1
Herson, J1
Wharton, JT1
Rutledge, FN1
Goldberg, RS1
Griffin, JP1
McSherry, JW1
Krakoff, IH1
Van Echo, DA1
Chiuten, DF1
Whitacre, M1
Aisner, J1
Lichtenfeld, JL1
Wiernik, PH1
Lopez, JA1
Krikorian, JG1
Dias, SF1
Spiers, AS1
Finkel, HE1
Barnard, DE1
Casper, ES1
Gralla, RJ1
Lynch, GR1
Jones, BR1
Woodcock, TM1
Gordon, C1
Kelsen, DP1
Young, CW1
Seski, JC1
Edwards, CL1
Copeland, LJ1
Gershenson, DM1
Chang, YC1
Falkson, G1
Tormey, DC1
Crowley, J1
Johnson, BL1
Fisher, RI1
Bender, RA1
DeVita, VT1
Chabner, BA1
Young, RC1
Fabian, CJ1
Rasmussen, S1
Stephens, R1
Haut, A1
Smith, F1
Balcerzak, S1
Tranum, B1
Wilson, WL1
Ryzin, JV1
Weiss, AJ1
Frelick, RW1
Moss, SE1
Denefrio, JM1
Vogel, CL1
Ames, MM1
Richardson, RL1
Kovach, JS1
Moertel, CG1
O'Connell, MJ1
Wilman, DE1

Trials

7 trials available for altretamine and Nausea

ArticleYear
Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies.
    British journal of cancer, 1983, Volume: 47, Issue:1

    Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Clinical Trials as Topic; Female; Humans; Kinetics;

1983
cis-Platinum, adriamycin, and hexamethylmelamine versus cyclophosphamide in advanced ovarian carcinoma.
    Cancer chemotherapy and pharmacology, 1983, Volume: 10, Issue:2

    Topics: Adult; Aged; Altretamine; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Femal

1983
Randomized phase II trial of hexamethylmelamine versus pentamethylmelamine in carcinoma of the bilharzial bladder.
    Cancer treatment reports, 1984, Volume: 68, Issue:5

    Topics: Altretamine; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evaluation; Humans; Nausea; Rando

1984
Single-agent chemotherapy for recurrent carcinoma of the cervix.
    Cancer clinical trials, 1980, Volume: 3, Issue:4

    Topics: Altretamine; Anemia; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Doxorubicin;

1980
Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study.
    Cancer treatment reports, 1979, Volume: 63, Issue:8

    Topics: Aged; Altretamine; Breast Neoplasms; Drug Evaluation; Female; Humans; Middle Aged; Nausea; Nervous S

1979
A phase III study in lung carcinoma comparing hexamethyl-melamine (NSC 13875) to dibromodulcitol (NSC 104800) 1,2.
    Oncology, 1975, Volume: 31, Issue:5-6

    Topics: Adenocarcinoma; Altretamine; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Clinical Trials as Top

1975
Phase I and clinical pharmacological evaluation of a parenteral hexamethylmelamine formulation.
    Cancer research, 1990, Jan-01, Volume: 50, Issue:1

    Topics: Altretamine; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Female; Humans

1990

Other Studies

11 other studies available for altretamine and Nausea

ArticleYear
Hexamethylmelamine in advanced head and neck cancer. A phase II study.
    American journal of clinical oncology, 1984, Volume: 7, Issue:3

    Topics: Aged; Altretamine; Carcinoma, Squamous Cell; Drug Evaluation; Egypt; Female; Head and Neck Neoplasms

1984
An evaluation of hexamethylmelamine, cis-diamminedichloroplatinum, and mitomycin-C in advanced breast cancer. A pilot study of the Southeastern Cancer Study Group.
    Cancer clinical trials, 1980, Volume: 3, Issue:4

    Topics: Altretamine; Breast Neoplasms; Cisplatin; Drug Evaluation; Drug Therapy, Combination; Female; Humans

1980
Phase I study of pentamethylmelamine.
    Cancer treatment reports, 1980, Volume: 64, Issue:12

    Topics: Adult; Altretamine; Dose-Response Relationship, Drug; Drug Evaluation; Electroencephalography; Human

1980
Phase I trial of pentamethylmelamine in patients with previously treated malignancies.
    Cancer treatment reports, 1980, Volume: 64, Issue:12

    Topics: Adult; Aged; Altretamine; Anorexia; Central Nervous System; Dose-Response Relationship, Drug; Drug A

1980
cis-Platinum-hexamethylmelamine therapy of advanced ovarian cancer.
    Gynecologic oncology, 1981, Volume: 11, Issue:1

    Topics: Adult; Altretamine; Cisplatin; Drug Therapy, Combination; Female; Humans; Middle Aged; Nausea; Ovari

1981
Phase I and pharmacological studies of pentamethylmelamine administered by 24-hour intravenous infusion.
    Cancer research, 1981, Volume: 41, Issue:4

    Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Fema

1981
Hexamethylmelamine chemotherapy for disseminated endometrial cancer.
    Obstetrics and gynecology, 1981, Volume: 58, Issue:3

    Topics: Aged; Altretamine; Ataxia; Confusion; Female; Humans; Middle Aged; Muscle Hypotonia; Nausea; Reflex,

1981
Phase I--II evaluation of combination cyclophosphamide, 5-fluorouracil, hexamethylmelamine, and prednisone in advanced breast cancer.
    Cancer clinical trials, 1981,Winter, Volume: 4, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Altretamine; Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide;

1981
Hexamethylmelamine in alkylating agent-resistant ovarian carcinoma.
    Cancer, 1978, Volume: 42, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Alkylating Agents; Altretamine; Bone Marrow; Drug Resistance; Female; H

1978
Phae II study of hexamethylmelamine in women with advanced breast cancer refractory to standard cytotoxic therapy.
    Cancer treatment reports, 1978, Volume: 62, Issue:1

    Topics: Alkylating Agents; Altretamine; Breast Neoplasms; Drug Evaluation; Drug Resistance; Female; Humans;

1978
Prodrugs in cancer chemotherapy.
    Biochemical Society transactions, 1986, Volume: 14, Issue:2

    Topics: Altretamine; Aniline Mustard; Animals; Antineoplastic Agents; Azo Compounds; Biotransformation; Chem

1986