altretamine has been researched along with Lung Neoplasms in 45 studies
Altretamine: A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The human lung carcinoma MV522 cell line and its corresponding xenograft model were used to evaluate the activity of irofulven in combination with different DNA damaging agents." | 3.74 | Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. ( Estes, LA; Kelner, MJ; McMorris, TC; Rojas, RJ; Suthipinijtham, P, 2008) |
| "Altretamine is a National Cancer Institute-designated group C antineoplastic agent used in the treatment of advanced ovarian cancer." | 2.38 | Altretamine. ( Hansen, LA; Hughes, TE, 1991) |
| " Further phase I studies, with different PMM dosage schedules, are necessary before phase II studies can be recommended." | 1.27 | Hexamethylmelamine and pentamethylmelamine: an update. ( Hahn, DA, 1983) |
| "Its activity is most marked in ovarian cancer, lymphomas, and carcinoma of the cervix; the drug is also active in bronchogenic carcinoma and carcinoma of the breast." | 1.26 | Hexamethylmelamine. An evaluation of its role in the therapy of cancer. ( Carter, SK; Legha, SS; Slavik, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (80.00) | 18.7374 |
| 1990's | 7 (15.56) | 18.2507 |
| 2000's | 2 (4.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Green, MR | 2 |
| Kelner, MJ | 1 |
| McMorris, TC | 1 |
| Rojas, RJ | 1 |
| Estes, LA | 1 |
| Suthipinijtham, P | 1 |
| Joss, RA | 2 |
| Obrecht, JP | 1 |
| Jungi, WF | 1 |
| Alberto, P | 1 |
| Sauter, C | 1 |
| Cavalli, F | 1 |
| Daugaard, G | 1 |
| Hansen, HH | 1 |
| Rørth, M | 1 |
| Presant, CA | 1 |
| Metter, GE | 1 |
| Multhauf, P | 1 |
| Bertrand, M | 1 |
| Chang, FF | 1 |
| Klein, L | 1 |
| Rappaport, D | 1 |
| Kendregan, B | 1 |
| Mackie, A | 1 |
| Dara, P | 1 |
| Schultz, MJ | 1 |
| Slater, LM | 1 |
| Armentrout, SA | 1 |
| Goldsweig, HG | 1 |
| Edgerton, F | 1 |
| Redden, CS | 1 |
| Takita, H | 2 |
| Garza, JG | 1 |
| Bisel, HF | 1 |
| Young, JA | 1 |
| Dillman, RO | 1 |
| Seagren, SL | 1 |
| Taetle, R | 1 |
| Rentschler, RE | 1 |
| Lea, JW | 1 |
| Lehar, TJ | 1 |
| Stanton, W | 1 |
| Mendelsohn, J | 1 |
| Royston, I | 1 |
| Brunner, KW | 1 |
| Goldhirsch, A | 1 |
| Hahn, DA | 1 |
| Green, M | 1 |
| Horton, C | 1 |
| Spaulding, M | 1 |
| Silver, RT | 1 |
| Berenberg, J | 1 |
| Kennedy, BJ | 1 |
| Pajak, TF | 1 |
| Comis, R | 1 |
| Chahinian, AP | 2 |
| Green, G | 1 |
| Holland, JF | 2 |
| Casper, ES | 1 |
| Gralla, RJ | 1 |
| Lynch, GR | 1 |
| Jones, BR | 1 |
| Woodcock, TM | 1 |
| Gordon, C | 1 |
| Kelsen, DP | 1 |
| Young, CW | 1 |
| Quayle, JB | 1 |
| Postmus, PE | 2 |
| Smit, EF | 1 |
| Lee, CR | 1 |
| Faulds, D | 1 |
| Broder, LE | 1 |
| Sridhar, KS | 1 |
| Selawry, OS | 1 |
| Charyulu, KN | 1 |
| Rao, RK | 1 |
| Saldana, MJ | 1 |
| Donnelly, EJ | 1 |
| Raub, WA | 1 |
| Gray, RJ | 1 |
| Mintz, U | 1 |
| Bitran, JD | 2 |
| Cooksey, JA | 1 |
| Desser, RK | 1 |
| DeMeester, TR | 1 |
| Golomb, HM | 2 |
| Krauss, S | 1 |
| Tornyos, K | 1 |
| DeSimone, P | 1 |
| Lowenbraun, S | 1 |
| McKeown, J | 1 |
| Solomon, A | 1 |
| Sonoda, T | 1 |
| Miller, CF | 1 |
| Weltz, MD | 1 |
| Heim, WJ | 1 |
| Blom, J | 1 |
| Wilson, WL | 3 |
| Ryzin, JV | 1 |
| Weiss, AJ | 1 |
| Frelick, RW | 2 |
| Moss, SE | 1 |
| Huang, MN | 1 |
| Catane, H | 1 |
| Yee Chen, T | 1 |
| Weiss, RB | 1 |
| Ginsberg, SJ | 1 |
| Comis, RL | 3 |
| Gottlieb, AJ | 1 |
| King, GB | 1 |
| Goldberg, J | 1 |
| Zamkoff, K | 1 |
| Elbadawi, A | 1 |
| Meyer, JA | 1 |
| Cumber, AJ | 2 |
| Ross, WC | 2 |
| Connors, TA | 1 |
| Clarke, SA | 1 |
| Mitchley, BC | 1 |
| Holoye, PY | 1 |
| Lake, LM | 1 |
| Grunden, EE | 1 |
| Johnson, BM | 1 |
| DiBella, NJ | 1 |
| Nelson, RA | 1 |
| Norgard, MJ | 1 |
| Andrews, NC | 1 |
| Nealon, TF | 1 |
| Bick, RL | 1 |
| Adams, T | 1 |
| Hill, GJ | 1 |
| Johnson, RO | 1 |
| Metter, G | 1 |
| Davis, HL | 1 |
| Grage, T | 1 |
| Fletcher, WS | 1 |
| Golomb, FM | 1 |
| Cruz, AB | 1 |
| Legha, SS | 1 |
| Slavik, M | 1 |
| Carter, SK | 1 |
| Hansen, LA | 1 |
| Hughes, TE | 1 |
| Ettinger, DS | 1 |
| Finkelstein, DM | 1 |
| Abeloff, MD | 2 |
| Ruckdeschel, JC | 1 |
| Aisner, SC | 1 |
| Eggleston, JC | 1 |
| Viallet, J | 1 |
| Ihde, DC | 1 |
| Propert, KJ | 1 |
| Ware, JH | 1 |
| Zimmer, B | 1 |
| Perry, MC | 1 |
| Hirsh, V | 1 |
| Skarin, A | 1 |
| Kopel, S | 1 |
| Markman, M | 1 |
| Berkman, AW | 1 |
| Waterfield, WC | 1 |
| Livingston, RB | 1 |
| Sleijfer, DT | 1 |
| Meinesz, AF | 1 |
| Kerstjens, HA | 1 |
| Lo, GT | 1 |
| Sluiter, HJ | 1 |
| Jacobs, RH | 1 |
| Greenburg, A | 1 |
| Hoffman, PC | 1 |
| Albain, KS | 1 |
| Desser, R | 1 |
| Potkul, L | 1 |
| Bonomi, PD | 1 |
| Pazdur, R | 1 |
| Stolbach, L | 1 |
| Mason, B | 1 |
| Ettinger, D | 1 |
| Remick, SC | 1 |
| Neville, AJ | 1 |
| Willson, JK | 1 |
| Fuller, AF | 1 |
| Krane, IM | 1 |
| Budzik, GP | 1 |
| Donahoe, PK | 1 |
6 reviews available for altretamine and Lung Neoplasms
| Article | Year |
|---|---|
Oral therapy for small cell lung cancer.
Topics: Administration, Oral; Altretamine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Proto | 1995 |
Altretamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cancer chemotherapy.
Topics: Altretamine; Antineoplastic Agents; Female; Humans; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Sa | 1995 |
Small-cell carcinoma of the lung: therapeutic management.
Topics: Alkylating Agents; Altretamine; Antineoplastic Agents; Brain; Carcinoma, Small Cell; Doxorubicin; Dr | 1978 |
Hexamethylmelamine (altretamine) in small cell lung cancer (SCLC).
Topics: Altretamine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small | 1991 |
Altretamine.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Cy | 1991 |
Current chemotherapy of small cell lung cancer.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Combi | 1986 |
12 trials available for altretamine and Lung Neoplasms
| Article | Year |
|---|---|
Effects of amphotericin B with combination chemotherapy on response rates and on survival in non-small cell carcinoma of the lung.
Topics: Altretamine; Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic | 1984 |
Hexamethylmelamine as a single agent in the treatment of small-cell carcinoma of the lung.
Topics: Adult; Aged; Altretamine; Carcinoma, Small Cell; Clinical Trials as Topic; Humans; Leukopenia; Lung | 1982 |
Four-drug combination chemotherapy (methotrexate, cyclophosphamide, hexamethylmelamine, and CCNU) for non-small cell bronchogenic carcinoma: a Cancer and Leukemia Group B study.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Clinical Trial | 1983 |
Mitomycin-C, etoposide, cisplatin, and hexamethylmelamine (MEPH) as a second-line regimen in lung cancer.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Cy | 1984 |
A randomized clinical trial in bronchogenic small-cell carcinoma evaluating alternating maintenance therapy of vincristine, adriamycin, procarbazine, and etoposide (VAPE) with cyclophosphamide, CCNU, and methotrexate (CCM) versus CCM maintenance alone in
Topics: Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinom | 1994 |
Hexamethylmelamine, bleomycin, and CCNU chemotherapy for patients with squamous cell carcinoma, large cell carcinoma, and adenocarcinoma of the lung unresponsive to cyclophosphamide, adriamycin, methotrexate, and procarbazine.
Topics: Adenocarcinoma; Adult; Aged; Altretamine; Bleomycin; Carcinoma, Small Cell; Carcinoma, Squamous Cell | 1978 |
cis-Dichlorodiammineplatinum(II) and hexamethylmelamine in the treatment of non-oat cell lung cancer: a pilot study of the Southeastern Cancer Study Group.
Topics: Adenocarcinoma; Adult; Aged; Altretamine; Carcinoma; Carcinoma, Squamous Cell; Cisplatin; Clinical T | 1979 |
A phase III study in lung carcinoma comparing hexamethyl-melamine (NSC 13875) to dibromodulcitol (NSC 104800) 1,2.
Topics: Adenocarcinoma; Altretamine; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Clinical Trials as Top | 1975 |
Preliminary report on the use of CCNU (NSC-79037), adriamycin (NSC-123127), and hexamethylmelamine (NSC-13875) in carcinoma of the lung.
Topics: Adult; Aged; Altretamine; Carcinoma, Squamous Cell; Clinical Trials as Topic; Doxorubicin; Drug Eval | 1976 |
A randomized comparison of standard chemotherapy versus alternating chemotherapy and maintenance versus no maintenance therapy for extensive-stage small-cell lung cancer: a phase III study of the Eastern Cooperative Oncology Group.
Topics: Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cyclophosp | 1990 |
A randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung cancer by the Cancer and Leukemia Group B.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Clini | 1989 |
Phase II trial evaluating continuous infusion of etoposide, cisplatin, and hexamethylmelamine in extensive-disease small cell carcinoma of the lung.
Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cis | 1987 |
27 other studies available for altretamine and Lung Neoplasms
| Article | Year |
|---|---|
Lessons from a time capsule: evolution, not revolution, in therapy for advanced non-small-cell lung cancer.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Non | 2008 |
Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model.
Topics: Altretamine; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protoc | 2008 |
Phase-II study of vindesine and hexamethylmelamine in patients with relapsing small cell carcinoma of the lung.
Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Dru | 1984 |
Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.
Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carc | 1984 |
Doxorubicin-hexamethylmelamine therapy of small cell carcinoma of the lung.
Topics: Adult; Aged; Altretamine; Carcinoma, Small Cell; Doxorubicin; Female; Humans; Lung Neoplasms; Male; | 1981 |
Non-cross-resistant chemotherapy and consolidation radiotherapy for small cell carcinoma of the lung.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Carcinoma, Small Cell; Cyclophosphamide; Doxorubici | 1982 |
Mitomycin, hexamethylmelamine, and vindesine as second-line treatment for small cell cancer of the lung.
Topics: Altretamine; Antineoplastic Agents; Carcinoma, Small Cell; Drug Therapy, Combination; Humans; Leukoc | 1982 |
Hexamethylmelamine and pentamethylmelamine: an update.
Topics: Altretamine; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans; Leukemia; Lung Neopla | 1983 |
Phase I and pharmacological studies of pentamethylmelamine administered by 24-hour intravenous infusion.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Fema | 1981 |
Tumour lysis as a factor affecting blood levels of CEA.
Topics: Altretamine; Animals; Breast Neoplasms; Carcinoembryonic Antigen; Cell Line; Colonic Neoplasms; Cycl | 1982 |
A Bayesian analysis of institutional effects in a multicenter cancer clinical trial.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Biometry; Carcinoma, Sma | 1994 |
Six-drug combination chemotherapy for nonresectable bronchogenic carcinoma.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Carcinoma, Bronchogenic; Cyclophosphamide; Doxorubi | 1979 |
Therapy of small cell carcinoma of the lung with hexamethylmelamine.
Topics: Adult; Aged; Altretamine; Carcinoma, Small Cell; Drug Therapy, Combination; Female; Humans; Lung Neo | 1978 |
Long-term survivorship in small-cell anaplastic lung carcinoma.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Carcinoma, Small Cell; Cyclophosphamide; Doxorubici | 1979 |
Analogues of hexamethylmelamine. The anti-neoplastic activity of derivatives with enhanced water solubility.
Topics: Altretamine; Animals; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation; Neoplasms, Experimenta | 1977 |
Regression of human lung tumor xenografts induced by water-soluble analogs of hexamethylmelamine.
Topics: Altretamine; Animals; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Male; Mice; Neoplasm Transpl | 1977 |
Management of small-cell bronchogenic carcinoma.
Topics: Altretamine; Antibiotics, Antineoplastic; Brain Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide | 1978 |
Toxicity and antitumor activity of hexamethylmelamine and its N-demethylated metabolites in mice with transplantable tumors.
Topics: Altretamine; Animals; Lethal Dose 50; Leukemia L1210; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL | 1975 |
Combination chemotherapy with CCNU (NSC-79037),hexamethylmelamine (NSC-13875) and methotrexate (NSC-740) in advanced bronchogenic carcinoma.
Topics: Aged; Altretamine; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Drug Evaluation; Female; Human | 1975 |
Multimodal surgical adjuvant therapy for a broad spectrum of tumors in humans.?
Topics: Adult; Altretamine; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Carmustine; Colonic Neo | 1976 |
Hexamethylmelamine. An evaluation of its role in the therapy of cancer.
Topics: Altretamine; Animals; Breast Neoplasms; Carcinoma, Bronchogenic; Chemical Phenomena; Chemistry; Drug | 1976 |
Systemic therapy for small-cell lung cancer: old themes replayed, new ones awaited.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Cyclo | 1989 |
Intensive alternating chemotherapy regimen in small cell carcinoma of the lung.
Topics: Actuarial Analysis; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow D | 1985 |
No response improvement after sequential chemotherapy for small cell lung cancer.
Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cis | 1986 |
A 10-year experience with combined modality therapy for stage III small cell lung carcinoma.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Combined Modalit | 1986 |
Phase II trial of mitomycin, vindesine, and hexamethylmelamine in metastatic non-small cell bronchogenic carcinoma.
Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; C | 1986 |
Mullerian inhibiting substance reduction of colony growth of human gynecologic cancers in a stem cell assay.
Topics: Adenocarcinoma; Altretamine; Anti-Mullerian Hormone; Ascitic Fluid; Carcinoma; Chromatography, Affin | 1985 |