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altretamine and Breast Neoplasms

altretamine has been researched along with Breast Neoplasms in 16 studies

Altretamine: A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.

Breast Neoplasms: Tumors or cancer of the human BREAST.

Research Excerpts

ExcerptRelevanceReference
"A four-drug combination of intermittent high-dose cyclophosphamide with 5-fluorouracil, hexamethylmelamine, and prednisone was given to 19 patients with advanced breast cancer."7.66Phase I--II evaluation of combination cyclophosphamide, 5-fluorouracil, hexamethylmelamine, and prednisone in advanced breast cancer. ( Chang, YC; Crowley, J; Falkson, G; Tormey, DC, 1981)
"A four-drug combination of intermittent high-dose cyclophosphamide with 5-fluorouracil, hexamethylmelamine, and prednisone was given to 19 patients with advanced breast cancer."3.66Phase I--II evaluation of combination cyclophosphamide, 5-fluorouracil, hexamethylmelamine, and prednisone in advanced breast cancer. ( Chang, YC; Crowley, J; Falkson, G; Tormey, DC, 1981)
" Fifteen patients with sarcoma metastases in the soft tissue were treated with karminomycin in combnation with methotrexate and cyclophosphane."3.65[Carminomycin in drug combination in breast cancer and soft tissue sarcomas]. ( Assekritova, IV; Gorbunova, VA; Lichinitser, MR, 1977)
"Ninety-eight patients with metastatic breast cancer, heavily pretreated with other agents, were entered in a phase II trial of hexamethylmelamine (HEX)."2.65Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study. ( Balcerzak, S; Fabian, CJ; Haut, A; Rasmussen, S; Smith, F; Stephens, R; Tranum, B, 1979)
"Five human breast carcinoma xenografts, MX-1, T-61, MCF-7, R-27 and Br-10, were inoculated subcutaneously into female nude mice."1.29In vivo antitumor activity of hexamethylmelamine against human breast, stomach and colon carcinoma xenografts. ( Furukawa, T; Kase, S; Kitajima, M; Koh, J; Kubota, T; Kuo, TH; Naito, Y; Saikawa, Y; Tanino, H; Yamada, Y, 1995)
"Twenty-three patients with metastatic breast carcinoma were induced with a complex systemic therapy regimen in an attempt to ascertain if a complete remission rate greater than 50% could be obtained with intensive drug exposure."1.27Short term high density systemic therapy for metastatic breast cancer. ( Carbone, PP; Davis, TE; Kline, JC; Love, RR; Palta, M; Tormey, DC, 1985)
"Eleven patients with metastatic breast cancer refractory to conventional therapy were treated with a combination of hexamethylmelamine 250 mg/m2 p."1.26An evaluation of hexamethylmelamine, cis-diamminedichloroplatinum, and mitomycin-C in advanced breast cancer. A pilot study of the Southeastern Cancer Study Group. ( Lawson, D; Moore, M; Smalley, R, 1980)
" The limited therapeutic benefit did not justify the toxicity produced, and suggested that intensive dosage schedules of vincristine, and use of low dose hexamethylmelamine during the time of anticipated hematologic nadir counts would not be of substantial benefit."1.26Adriamycin, vincristine, dibromodulcitol, and hexamethylmelamine in advanced previously treated breast cancer: an ECOG pilot study. ( Taylor, SG; Wolter, J, 1981)
"Its activity is most marked in ovarian cancer, lymphomas, and carcinoma of the cervix; the drug is also active in bronchogenic carcinoma and carcinoma of the breast."1.26Hexamethylmelamine. An evaluation of its role in the therapy of cancer. ( Carter, SK; Legha, SS; Slavik, M, 1976)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199013 (81.25)18.7374
1990's3 (18.75)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carter, SK2
Lawson, D1
Moore, M1
Smalley, R1
Taylor, SG1
Wolter, J1
Chang, YC1
Falkson, G1
Tormey, DC2
Crowley, J1
Quayle, JB1
Tanino, H1
Kubota, T1
Yamada, Y1
Koh, J1
Kase, S1
Furukawa, T1
Kuo, TH1
Saikawa, Y1
Kitajima, M1
Naito, Y1
Yaguchi, S1
Izumisawa, Y1
Sato, M1
Nakagane, T1
Koshimizu, I1
Sakita, K1
Kato, M1
Yoshioka, K1
Sakato, M1
Kawashima, S1
Lichinitser, MR2
Perevodchikova, NI1
Garin, AM1
Asserkritova, IV1
Vaarik, GKh1
Van Amburg, AL1
Presant, CA1
Vélez-García, E1
Klahr, C1
Fabian, CJ1
Rasmussen, S1
Stephens, R1
Haut, A1
Smith, F1
Balcerzak, S1
Tranum, B1
Assekritova, IV1
Gorbunova, VA1
Denefrio, JM1
Vogel, CL1
Hill, GJ1
Johnson, RO1
Metter, G1
Wilson, WL1
Davis, HL1
Grage, T1
Fletcher, WS1
Golomb, FM1
Cruz, AB1
Legha, SS1
Slavik, M1
Henderson, IC1
Shapiro, CL1
Kline, JC1
Palta, M1
Davis, TE1
Love, RR1
Carbone, PP1

Reviews

2 reviews available for altretamine and Breast Neoplasms

ArticleYear
New cytotoxic drugs for breast cancer and their clinical evaluation.
    European journal of cancer, 1980, Volume: Suppl 1

    Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as

1980
Hexamethylmelamine use in the treatment of metastatic breast cancer.
    Cancer treatment reviews, 1991, Volume: 18 Suppl A

    Topics: Altretamine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms

1991

Trials

3 trials available for altretamine and Breast Neoplasms

ArticleYear
New cytotoxic drugs for breast cancer and their clinical evaluation.
    European journal of cancer, 1980, Volume: Suppl 1

    Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as

1980
Phase I--II study of hexamethylmelamine plus dibromodulcitol in refractory carcinoma of the breast.
    Cancer treatment reports, 1979, Volume: 63, Issue:1

    Topics: Adult; Aged; Altretamine; Breast Neoplasms; Clinical Trials as Topic; Drug Evaluation; Drug Therapy,

1979
Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study.
    Cancer treatment reports, 1979, Volume: 63, Issue:8

    Topics: Aged; Altretamine; Breast Neoplasms; Drug Evaluation; Female; Humans; Middle Aged; Nausea; Nervous S

1979

Other Studies

12 other studies available for altretamine and Breast Neoplasms

ArticleYear
An evaluation of hexamethylmelamine, cis-diamminedichloroplatinum, and mitomycin-C in advanced breast cancer. A pilot study of the Southeastern Cancer Study Group.
    Cancer clinical trials, 1980, Volume: 3, Issue:4

    Topics: Altretamine; Breast Neoplasms; Cisplatin; Drug Evaluation; Drug Therapy, Combination; Female; Humans

1980
Adriamycin, vincristine, dibromodulcitol, and hexamethylmelamine in advanced previously treated breast cancer: an ECOG pilot study.
    Medical and pediatric oncology, 1981, Volume: 9, Issue:2

    Topics: Aged; Altretamine; Breast Neoplasms; Doxorubicin; Drug Therapy, Combination; Female; Humans; Middle

1981
Phase I--II evaluation of combination cyclophosphamide, 5-fluorouracil, hexamethylmelamine, and prednisone in advanced breast cancer.
    Cancer clinical trials, 1981,Winter, Volume: 4, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Altretamine; Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide;

1981
Tumour lysis as a factor affecting blood levels of CEA.
    British journal of cancer, 1982, Volume: 46, Issue:2

    Topics: Altretamine; Animals; Breast Neoplasms; Carcinoembryonic Antigen; Cell Line; Colonic Neoplasms; Cycl

1982
In vivo antitumor activity of hexamethylmelamine against human breast, stomach and colon carcinoma xenografts.
    Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:8

    Topics: Altretamine; Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Colonic Neoplasms; Dose-R

1995
In vitro cytotoxicity of imidazolyl-1,3,5-triazine derivatives.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:6

    Topics: Altretamine; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Survival; Drug Screening Assays,

1997
[Effectiveness of ftorafur and hexamethylmelamine in advanced breast cancer].
    Voprosy onkologii, 1978, Volume: 24, Issue:8

    Topics: Adult; Altretamine; Breast Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leuko

1978
[Carminomycin in drug combination in breast cancer and soft tissue sarcomas].
    Antibiotiki, 1977, Volume: 22, Issue:10

    Topics: Aged; Altretamine; Antibiotics, Antineoplastic; Breast Neoplasms; Carubicin; Cyclophosphamide; Drug

1977
Phae II study of hexamethylmelamine in women with advanced breast cancer refractory to standard cytotoxic therapy.
    Cancer treatment reports, 1978, Volume: 62, Issue:1

    Topics: Alkylating Agents; Altretamine; Breast Neoplasms; Drug Evaluation; Drug Resistance; Female; Humans;

1978
Multimodal surgical adjuvant therapy for a broad spectrum of tumors in humans.?
    Surgery, gynecology & obstetrics, 1976, Volume: 142, Issue:6

    Topics: Adult; Altretamine; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Carmustine; Colonic Neo

1976
Hexamethylmelamine. An evaluation of its role in the therapy of cancer.
    Cancer, 1976, Volume: 38, Issue:1

    Topics: Altretamine; Animals; Breast Neoplasms; Carcinoma, Bronchogenic; Chemical Phenomena; Chemistry; Drug

1976
Short term high density systemic therapy for metastatic breast cancer.
    Breast cancer research and treatment, 1985, Volume: 5, Issue:2

    Topics: Altretamine; Antineoplastic Agents; Bleomycin; Breast Neoplasms; Combined Modality Therapy; Doxorubi

1985