altretamine has been researched along with Benign Neoplasms in 33 studies
Altretamine: A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic studies (100-500 mg m-2) indicated that PMM plasma levels are dose-dependent and that the PMM disposition-phase half-life is prolonged in patients with abnormal liver function." | 2.65 | Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies. ( Harrap, KR; Muindi, JR; Newell, DR; Smith, IE, 1983) |
| "A joint study of advanced gastric cancer was conducted between the Northern California Oncology Group and a Japanese Cooperative Group involving 13 major institutions through the US-Japan Program." | 1.27 | [Research project of cancer chemotherapy]. ( Ogawa, M, 1985) |
| "Pentamethylmelamine is a soluble monodemethylated derivative of hexamethylmelamine." | 1.26 | Phase I study of pentamethylmelamine. ( Goldberg, RS; Griffin, JP; Krakoff, IH; McSherry, JW, 1980) |
| " Reduced bioavailability of PMM and HMM p." | 1.26 | Disposition and metabolism of pentamethylmelamine and hexamethylmelamine in rabbits and humans. ( Ames, MM; Eagan, RT; Kovach, JS; Powis, G, 1979) |
| "Its activity is most marked in ovarian cancer, lymphomas, and carcinoma of the cervix; the drug is also active in bronchogenic carcinoma and carcinoma of the breast." | 1.26 | Hexamethylmelamine. An evaluation of its role in the therapy of cancer. ( Carter, SK; Legha, SS; Slavik, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (81.82) | 18.7374 |
| 1990's | 4 (12.12) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Muindi, JR | 1 |
| Newell, DR | 1 |
| Smith, IE | 1 |
| Harrap, KR | 1 |
| Bruckner, HW | 1 |
| Schleifer, SJ | 1 |
| Ogawa, M | 2 |
| Aabo, K | 1 |
| Lund, B | 1 |
| Bogden, AE | 1 |
| Griffin, W | 1 |
| Reich, SD | 1 |
| Costanza, ME | 1 |
| Cobb, WR | 1 |
| Braun, DP | 1 |
| Harris, JE | 1 |
| Dutcher, JS | 1 |
| Jones, RB | 1 |
| Boyd, MR | 1 |
| Goldberg, RS | 1 |
| Griffin, JP | 1 |
| McSherry, JW | 1 |
| Krakoff, IH | 1 |
| Van Echo, DA | 1 |
| Chiuten, DF | 1 |
| Whitacre, M | 1 |
| Aisner, J | 1 |
| Lichtenfeld, JL | 1 |
| Wiernik, PH | 1 |
| Benvenuto, JA | 1 |
| Stewart, DJ | 1 |
| Benjamin, RS | 1 |
| Smith, RG | 1 |
| Loo, TL | 1 |
| Ajani, JA | 1 |
| Cabanillas, FF | 1 |
| Bodey, GP | 1 |
| D'Incalci, M | 1 |
| Farina, P | 1 |
| Sessa, C | 1 |
| Erba, E | 1 |
| Madonna, R | 1 |
| Mangioni, C | 1 |
| Lee, CR | 1 |
| Faulds, D | 1 |
| Coley, HM | 1 |
| Carter, SK | 2 |
| Slavik, M | 2 |
| Ames, MM | 3 |
| Powis, G | 1 |
| Kovach, JS | 2 |
| Eagan, RT | 1 |
| Winokur, S | 1 |
| Cavalli, F | 1 |
| Carter, WH | 1 |
| Wampler, GL | 1 |
| Crews, SL | 1 |
| Howells, R | 1 |
| Longacre, D | 1 |
| Donavan, M | 1 |
| Paladine, W | 1 |
| Cunningham, T | 1 |
| Sponzo, R | 1 |
| Cox, PJ | 1 |
| Farmer, PB | 1 |
| Hill, GJ | 1 |
| Johnson, RO | 1 |
| Metter, G | 1 |
| Wilson, WL | 1 |
| Davis, HL | 1 |
| Grage, T | 1 |
| Fletcher, WS | 1 |
| Golomb, FM | 1 |
| Cruz, AB | 1 |
| Legha, SS | 1 |
| Macdonald, JS | 1 |
| Richardson, RL | 1 |
| Moertel, CG | 1 |
| O'Connell, MJ | 1 |
| Foster, BJ | 2 |
| Clagett-Carr, K | 1 |
| Hoth, D | 2 |
| Leyland-Jones, B | 2 |
| Wilman, DE | 1 |
| Harding, BJ | 1 |
| Miller, KJ | 1 |
| McGovern, RM | 1 |
| ten Bokkel Huinink, WW | 1 |
| vd Burg, ME | 1 |
| von Oosterom, AT | 1 |
| Vermorken, JB | 1 |
| Veenhof, C | 1 |
| Roosendaal, K | 1 |
9 reviews available for altretamine and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Altretamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cancer chemotherapy.
Topics: Altretamine; Antineoplastic Agents; Female; Humans; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Sa | 1995 |
N-(Hydroxymethyl) melamines.
Topics: Altretamine; Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Pha | 1997 |
Current investigational drugs of interest in the Chemotherapy Program of the National Cancer Institute.
Topics: Altretamine; Animals; Antineoplastic Agents; Asparaginase; Azacitidine; Bleomycin; Cisplatin; Dacarb | 1977 |
[New substances in oncologic therapy].
Topics: Alkylating Agents; Altretamine; Antimetabolites, Antineoplastic; Cisplatin; Dacarbazine; Doxorubicin | 1978 |
Towards selectivity? Approaches to the design of new anti-tumour agents--II.
Topics: Altretamine; Amino Acids; Antineoplastic Agents; Carbohydrates; Chelating Agents; Colchicine; Colori | 1977 |
Hexamethylmelamine: activity in lymphoma and other tumors.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Humans; Lymphoma; Neoplasms | 1991 |
Pentamethylmelamine: review of an aqueous analog of hexamethylmelamine.
Topics: Altretamine; Animals; Antineoplastic Agents; Clinical Trials as Topic; Dogs; Dose-Response Relations | 1986 |
Hexamethylmelamine: a critical review of an active drug.
Topics: Altretamine; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Humans; Kinet | 1986 |
5 trials available for altretamine and Benign Neoplasms
| Article | Year |
|---|---|
Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Clinical Trials as Topic; Female; Humans; Kinetics; | 1983 |
Hexamethylmelamine, vincristine, and methotrexate chemotherapy in advanced neoplasms.
Topics: Adult; Aged; Altretamine; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Metho | 1977 |
Phase I and clinical pharmacological evaluation of a parenteral hexamethylmelamine formulation.
Topics: Altretamine; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Female; Humans | 1990 |
Pentamethylmelamine: review of an aqueous analog of hexamethylmelamine.
Topics: Altretamine; Animals; Antineoplastic Agents; Clinical Trials as Topic; Dogs; Dose-Response Relations | 1986 |
A pilot study of CHAC-1.
Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Cl | 1985 |
20 other studies available for altretamine and Benign Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Orthostatic hypotension as a complication of hexamethylmelamine antidepressant interaction.
Topics: Aged; Altretamine; Antidepressive Agents; Drug Interactions; Female; Humans; Hypotension, Orthostati | 1983 |
[Current clinical status of new anticancer drugs].
Topics: Altretamine; Anthraquinones; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; | 1983 |
[Hexamethylmelamine (Hexastat)].
Topics: Altretamine; Chemical Phenomena; Chemistry; Female; Humans; Neoplasms; Triazines | 1984 |
Predictive testing with the subrenal capsule assay.
Topics: Altretamine; Animals; Antineoplastic Agents; Cyclophosphamide; Dacarbazine; Drug Evaluation, Preclin | 1984 |
Effects of combination chemotherapy on immunoregulatory cells in peripheral blood of solid tumor cancer patients: correlation with rebound overshoot immune function recovery.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Cell Adhesion; Drug Therapy, Combination; Fluoroura | 1981 |
A sensitive and specific assay for pentamethylmelamine in plasma: applicability to clinical studies.
Topics: Aged; Altretamine; Antineoplastic Agents; Female; Gas Chromatography-Mass Spectrometry; Half-Life; H | 1980 |
Phase I study of pentamethylmelamine.
Topics: Adult; Altretamine; Dose-Response Relationship, Drug; Drug Evaluation; Electroencephalography; Human | 1980 |
Phase I trial of pentamethylmelamine in patients with previously treated malignancies.
Topics: Adult; Aged; Altretamine; Anorexia; Central Nervous System; Dose-Response Relationship, Drug; Drug A | 1980 |
High-performance liquid chromatographic analysis of pentamethylmelamine and its metabolites in biological fluids.
Topics: Altretamine; Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Kinetics; Metaboli | 1981 |
Phase I trial of pentamethylmelamine.
Topics: Altretamine; Antineoplastic Agents; Bone Marrow; Central Nervous System; Drug Evaluation; Humans; Ne | 1982 |
Hexamethylmelamine tissue concentrations in pelvic cancer patients.
Topics: Adult; Aged; Altretamine; Female; Humans; Middle Aged; Neoplasms; Ovarian Neoplasms; Triazines | 1980 |
Disposition and metabolism of pentamethylmelamine and hexamethylmelamine in rabbits and humans.
Topics: Altretamine; Animals; Biological Availability; Drug Evaluation; Humans; Intestinal Absorption; Liver | 1979 |
Recent developments in cancer chemotherapy.
Topics: Altretamine; Antineoplastic Agents; Cisplatin; Estramustine; Ethyl Chloride; Humans; Neoplasms; Stre | 1977 |
On determining the levels of treatment to optimize the probability of a favorable response.
Topics: Altretamine; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration S | 1977 |
Multimodal surgical adjuvant therapy for a broad spectrum of tumors in humans.?
Topics: Adult; Altretamine; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Carmustine; Colonic Neo | 1976 |
Hexamethylmelamine. An evaluation of its role in the therapy of cancer.
Topics: Altretamine; Animals; Breast Neoplasms; Carcinoma, Bronchogenic; Chemical Phenomena; Chemistry; Drug | 1976 |
Prodrugs in cancer chemotherapy.
Topics: Altretamine; Aniline Mustard; Animals; Antineoplastic Agents; Azo Compounds; Biotransformation; Chem | 1986 |
[Research project of cancer chemotherapy].
Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Cisplatin; Dacarbazine; Etoposide; Hu | 1985 |
Effect of a hepatic activation system on the antiproliferative activity of hexamethylmelamine against human tumor cell lines.
Topics: Altretamine; Animals; Cell Division; Cell Line; Cyclophosphamide; Humans; Male; Microsomes, Liver; M | 1985 |