Compounds > alternariol-monomethyl-ether

alternariol-monomethyl-ether and Abnormalities--Drug-Induced

alternariol-monomethyl-ether has been researched along with Abnormalities--Drug-Induced* in 1 studies

Other Studies

1 other study(ies) available for alternariol-monomethyl-ether and Abnormalities--Drug-Induced

Article	Year
The subchronic toxicity and teratogenicity of alternariol monomethyl ether produced by Alternaria solani. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1982, Volume: 20, Issue:6 Alternariol monomethyl ether (AME), a metabolite of species of Alternaria, was studied for subchronic toxicity to rats and teratogenic effects in golden hamsters. In rats no toxic effects were observed at the highest dosage tested (3.75 mg given by oral gavage daily for 30 days). However, AME was maternally toxic and foetotoxic to Syrian golden hamsters when given ip at 200 mg/kg body weight on day 8 of gestation. No such effects were observed at dose levels of 50 or 100 mg/kg. Topics: Abnormalities, Drug-Induced; Alternaria; Animals; Cricetinae; Dose-Response Relationship, Drug; Female; Lactones; Male; Mesocricetus; Mitosporic Fungi; Mycotoxins; Pregnancy; Rats; Rats, Inbred Strains; Species Specificity; Teratogens; Time Factors	1982

Article

Year

The subchronic toxicity and teratogenicity of alternariol monomethyl ether produced by Alternaria solani.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1982, Volume: 20, Issue:6

Alternariol monomethyl ether (AME), a metabolite of species of Alternaria, was studied for subchronic toxicity to rats and teratogenic effects in golden hamsters. In rats no toxic effects were observed at the highest dosage tested (3.75 mg given by oral gavage daily for 30 days). However, AME was maternally toxic and foetotoxic to Syrian golden hamsters when given ip at 200 mg/kg body weight on day 8 of gestation. No such effects were observed at dose levels of 50 or 100 mg/kg.

Topics: Abnormalities, Drug-Induced; Alternaria; Animals; Cricetinae; Dose-Response Relationship, Drug; Female; Lactones; Male; Mesocricetus; Mitosporic Fungi; Mycotoxins; Pregnancy; Rats; Rats, Inbred Strains; Species Specificity; Teratogens; Time Factors

1982