altanserin and Supranuclear-Palsy--Progressive

altanserin has been researched along with Supranuclear-Palsy--Progressive* in 1 studies

Other Studies

1 other study(ies) available for altanserin and Supranuclear-Palsy--Progressive

Article	Year
Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society, 2009, Jun-15, Volume: 24, Issue:8 A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT(2A)) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT(2A) receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5- HT(2A) receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings. Topics: Aged; Brain Mapping; Corpus Striatum; Female; Fluorine Radioisotopes; Humans; Ketanserin; Magnetic Resonance Imaging; Male; Middle Aged; Movement Disorders; Positron-Emission Tomography; Receptor, Serotonin, 5-HT2A; Statistics as Topic; Substantia Nigra; Supranuclear Palsy, Progressive; Up-Regulation	2009

Article

Year

Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy.

Movement disorders : official journal of the Movement Disorder Society, 2009, Jun-15, Volume: 24, Issue:8

A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT(2A)) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT(2A) receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5- HT(2A) receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings.

Topics: Aged; Brain Mapping; Corpus Striatum; Female; Fluorine Radioisotopes; Humans; Ketanserin; Magnetic Resonance Imaging; Male; Middle Aged; Movement Disorders; Positron-Emission Tomography; Receptor, Serotonin, 5-HT2A; Statistics as Topic; Substantia Nigra; Supranuclear Palsy, Progressive; Up-Regulation

2009