alprazolam has been researched along with Huntington Disease in 2 studies
Alprazolam: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
alprazolam : A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Transgenic R6/2 mice carrying the Huntington's disease (HD) mutation show disrupted circadian rhythms that worsen as the disease progresses." | 1.34 | Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. ( Chesham, JE; Dyball, R; Hastings, MH; Inyushkin, AN; Maywood, ES; Morton, AJ; Pallier, PN; Zheng, Z, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pallier, PN | 2 |
| Morton, AJ | 2 |
| Maywood, ES | 1 |
| Zheng, Z | 1 |
| Chesham, JE | 1 |
| Inyushkin, AN | 1 |
| Dyball, R | 1 |
| Hastings, MH | 1 |
2 other studies available for alprazolam and Huntington Disease
| Article | Year |
|---|---|
Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease.
Topics: Affect; Alprazolam; Animals; Benzhydryl Compounds; Body Weight; Central Nervous System Stimulants; C | 2009 |
Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease.
Topics: Age Factors; Alprazolam; Animals; Cell Cycle Proteins; Chloral Hydrate; Choice Behavior; Circadian R | 2007 |