alprazolam has been researched along with Drug Overdose in 29 studies
Alprazolam: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
alprazolam : A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of flumazenil, a benzodiazepine antagonist, was studied in two patients with coma of unknown etiology." | 9.06 | The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology. ( Burkhart, KK; Kulig, KW, 1990) |
| "The use of flumazenil, a benzodiazepine antagonist, was studied in two patients with coma of unknown etiology." | 5.06 | The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology. ( Burkhart, KK; Kulig, KW, 1990) |
| "We present the case of a comatose woman who intentionally overdosed on amitriptyline and displayed rising serum total tricyclic antidepressant concentrations for at least 6 days after admission." | 3.77 | Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity. ( Curry, SC; Smith, JC, 2011) |
| "A 30-year-old woman, with history of depression, was found dead after the ingestion of an unknown quantity of Xanax (alprazolam), Tramal (tramadol) and alcohol." | 3.70 | Fatal overdose of tramadol and alprazolam. ( Augsburger, M; Giroud, C; Mangin, P; Michaud, K; Romain, N, 1999) |
| "Toxic leukoencephalopathy can occur acutely following an overdose of benzodiazepine and respiratory failure." | 2.52 | Acute fatal posthypoxic leukoencephalopathy following benzodiazepine overdose: a case report and review of the literature. ( Al-Hussain, F; Aljarallah, S, 2015) |
| "Alprazolam was significantly more toxic than other benzodiazepines." | 2.42 | Alprazolam is relatively more toxic than other benzodiazepines in overdose. ( Isbister, GK; O'Regan, L; Sibbritt, D; Whyte, IM, 2004) |
| "Hyperkalemia is a potentially life-threatening electrolyte abnormality commonly seen in the emergency department (ED)." | 1.40 | Endoscopic removal of pharmacobezoar in case of intentional potassium overdose. ( Briggs, AL; Deal, LL, 2014) |
| "Alprazolam was a contributing cause of death in a substantial and increasing number of drug-related deaths." | 1.38 | Characteristics of alprazolam-related deaths compiled by a centralized state medical examiner. ( Abate, MA; Clay, DJ; Kaplan, JA; Kraner, JC; Shah, NA; Smith, MJ, 2012) |
| "Zolpidem was not present." | 1.35 | A fatal case of benzodiazepine withdrawal. ( Lann, MA; Molina, DK, 2009) |
| "One patient died of pulmonary edema and subsequent heart failure, but the rest of the patients recovered without any sequelae." | 1.34 | Hemoperfusion in the treatment of acute clozapine intoxication in China. ( Cai, ZJ; He, JL; Li, WB; Ungvari, GS; Xiang, YT, 2007) |
| "Alprazolam is a commonly prescribed benzodiazepine." | 1.33 | Alprazolam-related deaths in Palm Beach County. ( Flannagan, LM; Lavezzi, WA; Middleberg, RA; Sullivan, LM; Wolf, BC, 2005) |
| "Alprazolam has been relatively difficult to confirm." | 1.30 | Detection of alprazolam in three cases of methadone/benzodiazepine overdose. ( Brissie, RM; Hall, MA; Robinson, CA; Rogers, WO, 1997) |
| "The alprazolam concentration was reported at 33 microg/L in heart blood, which is within the therapeutic range." | 1.30 | Fatal multiple drug intoxication following acute sertraline use. ( Brissie, RM; Davis, GG; Hall, M; Milner, DA; Robinson, CA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 13 (44.83) | 24.3611 |
| 2020's | 4 (13.79) | 2.80 |
| Authors | Studies |
|---|---|
| Calello, DP | 1 |
| Aldy, K | 1 |
| Jefri, M | 1 |
| Nguyen, TT | 1 |
| Krotulski, A | 1 |
| Logan, B | 1 |
| Brent, J | 1 |
| Wax, P | 1 |
| Walton, S | 1 |
| Manini, AF | 1 |
| Ellefsen, KN | 1 |
| Smith, CR | 1 |
| Taylor, EA | 1 |
| Hall, BJ | 1 |
| Walde, J | 1 |
| Andersson, L | 1 |
| Johnson, B | 1 |
| Håkansson, A | 1 |
| Brede, WR | 1 |
| Krabseth, HM | 1 |
| Michelsen, LS | 1 |
| Aarset, H | 1 |
| Jamt, JP | 1 |
| Slørdal, L | 1 |
| Chapman, BP | 1 |
| Lai, JT | 1 |
| Krotulski, AJ | 1 |
| Fogarty, MF | 1 |
| Griswold, MK | 1 |
| Logan, BK | 1 |
| Babu, KM | 1 |
| Shah, NA | 1 |
| Abate, MA | 1 |
| Smith, MJ | 1 |
| Kaplan, JA | 1 |
| Kraner, JC | 1 |
| Clay, DJ | 1 |
| Briggs, AL | 1 |
| Deal, LL | 1 |
| Eren Cevik, S | 1 |
| Tasyurek, T | 1 |
| Guneysel, O | 1 |
| Johnson, H | 1 |
| Paulozzi, L | 1 |
| Porucznik, C | 1 |
| Mack, K | 1 |
| Herter, B | 1 |
| McIntyre, IM | 1 |
| Hamm, CE | 1 |
| Sherrard, JL | 1 |
| Gary, RD | 1 |
| Burton, CG | 1 |
| Mena, O | 1 |
| Aljarallah, S | 1 |
| Al-Hussain, F | 1 |
| Lloyd, B | 1 |
| Dwyer, J | 1 |
| Bugeja, L | 1 |
| Jamieson, A | 1 |
| Lann, MA | 1 |
| Molina, DK | 1 |
| Kiran, HS | 1 |
| Ravikumar, YS | 1 |
| Jayasheelan, MR | 1 |
| Smith, JC | 1 |
| Curry, SC | 1 |
| Carroll, I | 1 |
| Heritier Barras, AC | 1 |
| Dirren, E | 1 |
| Burkhard, PR | 1 |
| Horvath, J | 1 |
| Francino, MC | 1 |
| Bretaudeau Deguigne, M | 1 |
| Badin, J | 1 |
| Turcant, A | 1 |
| Perrotin, D | 1 |
| Isbister, GK | 1 |
| O'Regan, L | 1 |
| Sibbritt, D | 1 |
| Whyte, IM | 1 |
| Wolf, BC | 1 |
| Lavezzi, WA | 1 |
| Sullivan, LM | 1 |
| Middleberg, RA | 1 |
| Flannagan, LM | 1 |
| He, JL | 1 |
| Xiang, YT | 1 |
| Li, WB | 1 |
| Cai, ZJ | 1 |
| Ungvari, GS | 1 |
| Mur, P | 1 |
| Rodriguez, M | 1 |
| Martínez-Cano, H | 1 |
| Vela-Bueno, A | 1 |
| Farr, I | 1 |
| De Iceta, M | 1 |
| Pomalima, R | 1 |
| Hall, MA | 2 |
| Robinson, CA | 3 |
| Brissie, RM | 3 |
| Rogers, WO | 1 |
| Milner, DA | 1 |
| Hall, M | 1 |
| Davis, GG | 1 |
| Michaud, K | 1 |
| Augsburger, M | 1 |
| Romain, N | 1 |
| Giroud, C | 1 |
| Mangin, P | 1 |
| Samal, KK | 1 |
| Parija, BL | 1 |
| Nanda, MK | 1 |
| Viswabandya, A | 1 |
| Patnaik, SR | 1 |
| Edwards, JG | 1 |
| Inman, WH | 1 |
| Pearce, GL | 1 |
| Rawson, NS | 1 |
| Burkhart, KK | 1 |
| Kulig, KW | 1 |
2 reviews available for alprazolam and Drug Overdose
| Article | Year |
|---|---|
Acute fatal posthypoxic leukoencephalopathy following benzodiazepine overdose: a case report and review of the literature.
Topics: Alprazolam; Benzodiazepines; Brain; Coma; Drug Overdose; Edema; Fatal Outcome; Humans; Hypoxia; Hypo | 2015 |
Alprazolam is relatively more toxic than other benzodiazepines in overdose.
Topics: Adolescent; Adult; Aged; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Critical Care; Diazepam; | 2004 |
1 trial available for alprazolam and Drug Overdose
| Article | Year |
|---|---|
The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology.
Topics: Adult; Alprazolam; Carbon Monoxide Poisoning; Clinical Trials as Topic; Coma; Double-Blind Method; D | 1990 |
26 other studies available for alprazolam and Drug Overdose
| Article | Year |
|---|---|
Identification of a novel opioid,
Topics: Adult; Alprazolam; Analgesics, Opioid; Benzimidazoles; Cocaine; Codeine; Drug Overdose; Fentanyl; He | 2022 |
Emergence of fentanyl-related deaths in Travis County, Texas and surrounding areas: A retrospective review of postmortem fentanyl-related drug toxicities from 2020 to 2022.
Topics: Alprazolam; Analgesics, Opioid; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fent | 2023 |
Drug prescriptions preceding opioid-related deaths-a register study in forensic autopsy patients.
Topics: Alprazolam; Analgesics, Opioid; Autopsy; Diazepam; Drug Overdose; Drug Prescriptions; Humans; Opioid | 2023 |
A Wolf in Sheep's Clothing.
Topics: Adult; Alprazolam; Drug Overdose; Fatal Outcome; Fentanyl; Humans; Illicit Drugs; Male; Substance Ab | 2019 |
A Case of Unintentional Opioid (U-47700) Overdose in a Young Adult After Counterfeit Xanax Use.
Topics: Alprazolam; Analgesics, Opioid; Benzamides; Drug Overdose; Humans; Male; Young Adult | 2021 |
Characteristics of alprazolam-related deaths compiled by a centralized state medical examiner.
Topics: Adult; Alprazolam; Analgesics, Opioid; Cardiovascular Diseases; Cause of Death; Comorbidity; Drug Ov | 2012 |
Endoscopic removal of pharmacobezoar in case of intentional potassium overdose.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Bezoars; Delayed-Action Preparations; Dietary Supplements; D | 2014 |
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications.
Topics: Adolescent; Adult; Alprazolam; Amitriptyline; Antidotes; Blood Pressure; Dibenzothiazepines; Drug Ov | 2014 |
Decline in drug overdose deaths after state policy changes - Florida, 2010-2012.
Topics: Adolescent; Adult; Alprazolam; Cause of Death; Child; Child, Preschool; Drug Overdose; Drug Prescrip | 2014 |
Acute 3,4-methylenedioxy-N-ethylcathinone (ethylone) intoxication and related fatality: a case report with postmortem concentrations.
Topics: Accidents; Acetone; Adult; Alprazolam; Autopsy; Cause of Death; Drug Overdose; Enzyme-Linked Immunos | 2015 |
Alprazolam in fatal overdose following regulatory rescheduling: A response to Deacon et al.
Topics: Alprazolam; Benzodiazepines; Drug Overdose; Humans | 2017 |
A fatal case of benzodiazepine withdrawal.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Diagnosis, Differential; Diagnostic Errors; Drug Overdose; F | 2009 |
Brugada like pattern in ECG with drug overdose.
Topics: Adult; Alprazolam; Antidepressive Agents, Tricyclic; Brugada Syndrome; Dothiepin; Drug Overdose; Ele | 2010 |
Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity.
Topics: Alprazolam; Amitriptyline; Antidepressive Agents, Tricyclic; Body Temperature; Brain; Coma; Cytochro | 2011 |
Drug overdose deaths--Florida, 2003-2009.
Topics: Alprazolam; Cause of Death; Cocaine; Drug Overdose; Florida; Humans; Illicit Drugs; Methadone; Morph | 2011 |
Delayed leukoencephalopathy after alprazolam and methadone overdose: a case report and review of the literature.
Topics: Adult; Alprazolam; Analgesics, Opioid; Behavior; Brain; Drug Overdose; Female; Glasgow Coma Scale; H | 2012 |
Hypoglycaemia: a little known effect of Venlafaxine overdose.
Topics: Adult; Alprazolam; Analgesics; Anti-Anxiety Agents; Cyclohexanols; Depression; Drug Overdose; Drug T | 2012 |
Alprazolam-related deaths in Palm Beach County.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alprazolam; Benzodiazepines; Cause of Death; Drug Overdo | 2005 |
Hemoperfusion in the treatment of acute clozapine intoxication in China.
Topics: Acute Disease; Adult; Alprazolam; Antipsychotic Agents; China; Clonazepam; Clozapine; Depressive Dis | 2007 |
Allergic and toxic reaction to alprazolam.
Topics: Adult; Alprazolam; Drug Hypersensitivity; Drug Overdose; Female; Humans | 1995 |
High-performance liquid chromatography of alprazolam in postmortem blood using solid-phase extraction.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Drug Overdose; Female; | 1995 |
Detection of alprazolam in three cases of methadone/benzodiazepine overdose.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Drug | 1997 |
Fatal multiple drug intoxication following acute sertraline use.
Topics: Alprazolam; Anti-Anxiety Agents; Antidepressive Agents; Chromatography, High Pressure Liquid; Drug I | 1998 |
Fatal overdose of tramadol and alprazolam.
Topics: Adult; Alcoholic Intoxication; Alprazolam; Analgesics, Opioid; Anti-Anxiety Agents; Autopsy; Cause o | 1999 |
Alprazolam poisoning.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Drug Overdose; Humans; Male; Suicide, Attempted | 1999 |
Prescription-event monitoring of 10,895 patients treated with alprazolam.
Topics: Adult; Aged; Alprazolam; Anxiety Disorders; Depressive Disorder; Drug Overdose; Female; Follow-Up St | 1991 |