alprazolam has been researched along with Alcoholism in 26 studies
Alprazolam: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
alprazolam : A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether females with a confirmed paternal history of alcoholism (FHP; n=14) were differentially sensitive to the mood and performance effects of alprazolam and buspirone compared with females without a first-degree family history of alcoholism (FHN; n=14)." | 9.09 | Increased sensitivity to alprazolam in females with a paternal history of alcoholism. ( Evans, SM; Fischman, MW; Levin, FR, 2000) |
| "This study sought to identify whether subjects with a family history (FH + ) of alcoholism had changes in regional cerebral blood volume (rCBV) after an alprazolam challenge which distinguished them from subjects without a family history (FH -) of alcoholism using functional MRI (fMRI)." | 9.08 | Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism. ( Ciraulo, AM; Ciraulo, DA; Harris, GJ; Kaufman, MJ; Knapp, CM; Lewis, RF; Maas, LC; Renshaw, PF; Streeter, CC; Szulewski, S; Ungeheuer, M, 1998) |
| "The objective of our study was to investigate the effect of 99366316G>A polymorphism of the CYP3A4 gene on the concentration/dose indicator of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder, using findings on enzymatic activity of CYP3A (as evaluated by the 6-beta-hydroxy-cortisol/cortisol ratio measurement) and on CYP3A4 expression level obtained by measuring the miR-27b plasma concentration levels in patients with anxiety disorders comorbid with alcoholism." | 7.96 | Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder. ( Bryun, EA; Bure, IV; Golovinskii, PA; Grishina, EA; Koporov, SG; Pankratenko, EP; Petukhov, AE; Ryzhikova, KA; Skryabin, VY; Smirnov, VV; Sychev, DA; Zastrozhin, MS; Zastrozhina, AK, 2020) |
| "To determine whether females with a confirmed paternal history of alcoholism (FHP; n=14) were differentially sensitive to the mood and performance effects of alprazolam and buspirone compared with females without a first-degree family history of alcoholism (FHN; n=14)." | 5.09 | Increased sensitivity to alprazolam in females with a paternal history of alcoholism. ( Evans, SM; Fischman, MW; Levin, FR, 2000) |
| "This study sought to identify whether subjects with a family history (FH + ) of alcoholism had changes in regional cerebral blood volume (rCBV) after an alprazolam challenge which distinguished them from subjects without a family history (FH -) of alcoholism using functional MRI (fMRI)." | 5.08 | Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism. ( Ciraulo, AM; Ciraulo, DA; Harris, GJ; Kaufman, MJ; Knapp, CM; Lewis, RF; Maas, LC; Renshaw, PF; Streeter, CC; Szulewski, S; Ungeheuer, M, 1998) |
| "The objective of our study was to investigate the effect of 99366316G>A polymorphism of the CYP3A4 gene on the concentration/dose indicator of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder, using findings on enzymatic activity of CYP3A (as evaluated by the 6-beta-hydroxy-cortisol/cortisol ratio measurement) and on CYP3A4 expression level obtained by measuring the miR-27b plasma concentration levels in patients with anxiety disorders comorbid with alcoholism." | 3.96 | Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder. ( Bryun, EA; Bure, IV; Golovinskii, PA; Grishina, EA; Koporov, SG; Pankratenko, EP; Petukhov, AE; Ryzhikova, KA; Skryabin, VY; Smirnov, VV; Sychev, DA; Zastrozhin, MS; Zastrozhina, AK, 2020) |
| "Nine of 12 men with a family history of alcoholism but only two of 12 control subjects had euphoric responses to alprazolam." | 3.67 | Parental alcoholism as a risk factor in benzodiazepine abuse: a pilot study. ( Barnhill, JG; Ciraulo, AM; Ciraulo, DA; Greenblatt, DJ; Shader, RI, 1989) |
| "Alprazolam was significantly more efficacious than both clonidine and placebo in decreasing withdrawal symptoms." | 2.67 | Double-blind study of alprazolam, diazepam, clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings. ( Adinoff, B, 1994) |
| "Alprazolam was as effective as diazepam in the relief of anxiety as measured by the Hamilton Anxiety Rating Scale, Physician's Global Impressions, Patient's Global Impressions, Hopkins Symptom Checklist and Target Symptoms Record." | 2.65 | Double-blind comparison of alprazolam and diazepam for subchronic withdrawal from alcohol. ( Kolin, IS; Linet, OI, 1981) |
| "Many patients with alcohol or drug abuse also have anxiety disorders for whom effective pharmacotherapy may be needed." | 2.38 | Alprazolam and benzodiazepine dependence. ( Ciraulo, DA; DuPont, RL; Griffiths, RR; Kosten, TR; Romach, MK; Sellers, EM; Woody, GE, 1993) |
| "Oxazepam is an anxiolytic with established clinical efficacy." | 2.38 | Oxazepam: update 1989. ( Ayd, FJ, 1990) |
| "Alprazolam is a benzodiazepine anxiolytic widely prescribed for treatment of panic-disorder and social phobias, although this medication is also subject to abuse." | 1.39 | Concentrations of alprazolam in blood from impaired drivers and forensic autopsies were not much different but showed a high prevalence of co-ingested illicit drugs. ( Holmgren, A; Jones, AW, 2013) |
| "Treatment with alprazolam (1 mg/Kg) partially reversed this adverse effect of stress." | 1.30 | Effects of alprazolam on the free-choice ethanol consumption induced by isolation stress in aged rats. ( Becerra, MA; De Miguel, S; Freire-Garabal, M; Legazpi, MP; Mayán, JM; Núñez, LA; Núñez, MJ; Quintans, MR; Rey-Méndez, M; Riveiro, P; Varela, M, 1999) |
| "All had withdrawal symptoms, six demonstrated tolerance, and at least four had substantial social or occupational impairment secondary to drug use." | 1.27 | Alprazolam dependence in seven patients. ( Juergens, SM; Morse, RM, 1988) |
| " No statistically significant differences in pharmacokinetic parameters were found between groups." | 1.27 | Abuse liability and clinical pharmacokinetics of alprazolam in alcoholic men. ( Barnhill, JG; Ciraulo, AM; Ciraulo, DA; Foti, ME; Greenblatt, DJ; Molloy, MA; Shader, RI; Tarmey, MF, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (26.92) | 18.7374 |
| 1990's | 13 (50.00) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Mills, WD | 1 |
| Greenhaw, RM | 1 |
| Wang, JMP | 1 |
| Zastrozhin, MS | 1 |
| Skryabin, VY | 1 |
| Smirnov, VV | 1 |
| Petukhov, AE | 1 |
| Pankratenko, EP | 1 |
| Zastrozhina, AK | 1 |
| Grishina, EA | 1 |
| Ryzhikova, KA | 1 |
| Bure, IV | 1 |
| Golovinskii, PA | 1 |
| Koporov, SG | 1 |
| Bryun, EA | 1 |
| Sychev, DA | 1 |
| Ries, R | 1 |
| Wolitzky-Taylor, KB | 1 |
| Operskalski, JT | 1 |
| Craske, MG | 1 |
| Roy-Byrne, P | 1 |
| Jones, AW | 1 |
| Holmgren, A | 1 |
| Kolin, IS | 1 |
| Linet, OI | 1 |
| Adinoff, B | 1 |
| Rosenfeld, DS | 1 |
| Furman, Y | 1 |
| Sellers, EM | 1 |
| Ciraulo, DA | 7 |
| DuPont, RL | 1 |
| Griffiths, RR | 1 |
| Kosten, TR | 1 |
| Romach, MK | 1 |
| Woody, GE | 1 |
| Sarid-Segal, O | 3 |
| Knapp, C | 2 |
| Ciraulo, AM | 6 |
| Greenblatt, DJ | 5 |
| Shader, RI | 5 |
| Lepola, U | 1 |
| Koponen, H | 1 |
| Leinonen, E | 1 |
| Barnhill, JG | 3 |
| Streeter, CC | 1 |
| Harris, GJ | 1 |
| Kaufman, MJ | 1 |
| Lewis, RF | 1 |
| Knapp, CM | 2 |
| Maas, LC | 1 |
| Ungeheuer, M | 1 |
| Szulewski, S | 1 |
| Renshaw, PF | 1 |
| Núñez, MJ | 1 |
| Riveiro, P | 1 |
| Becerra, MA | 1 |
| De Miguel, S | 1 |
| Quintans, MR | 1 |
| Núñez, LA | 1 |
| Legazpi, MP | 1 |
| Mayán, JM | 1 |
| Rey-Méndez, M | 1 |
| Varela, M | 1 |
| Freire-Garabal, M | 1 |
| Evans, SM | 1 |
| Levin, FR | 1 |
| Fischman, MW | 1 |
| Dreher, GK | 1 |
| Vargas, MA | 1 |
| Bissette, G | 1 |
| Owens, MJ | 1 |
| Ehlers, CL | 1 |
| Nemeroff, CB | 1 |
| Ayd, FJ | 1 |
| Diquet, B | 1 |
| Gujadhur, L | 1 |
| Lamiable, D | 1 |
| Warot, D | 1 |
| Hayoun, H | 1 |
| Choisy, H | 1 |
| Dickinson, B | 1 |
| Rush, PA | 1 |
| Radcliffe, AB | 1 |
| Rickels, K | 1 |
| Feighner, JP | 1 |
| Smith, WT | 1 |
| Fraser, AD | 1 |
| Isner, AF | 1 |
| Moss, MA | 1 |
| Juergens, SM | 1 |
| Morse, RM | 1 |
| Tarmey, MF | 1 |
| Molloy, MA | 1 |
| Foti, ME | 1 |
| Thweatt, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Continuing Care Following Drug Abuse Treatment: Linkage With Primary Care[NCT01621711] | 504 participants (Actual) | Interventional | 2011-03-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for alprazolam and Alcoholism
| Article | Year |
|---|---|
Pure sleep panic: two case reports and a review of the literature.
Topics: Adult; Alcoholism; Alprazolam; Arousal; Combined Modality Therapy; Depressive Disorder; Female; Huma | 1994 |
Alprazolam and benzodiazepine dependence.
Topics: Adult; Alcoholism; Alprazolam; Benzodiazepines; Comorbidity; Diazepam; Female; Humans; Incidence; Ma | 1993 |
Effects of chronic ethanol and benzodiazepine treatment and withdrawal on corticotropin-releasing factor neural systems.
Topics: Alcoholism; Alprazolam; Animals; Corticotropin-Releasing Hormone; Ethanol; Humans; Locus Coeruleus; | 1992 |
Oxazepam: update 1989.
Topics: Aged; Alcoholism; Alprazolam; Female; Humans; Oxazepam; Seizures; Substance Withdrawal Syndrome; Sub | 1990 |
7 trials available for alprazolam and Alcoholism
| Article | Year |
|---|---|
Double-blind comparison of alprazolam and diazepam for subchronic withdrawal from alcohol.
Topics: Adolescent; Adult; Aged; Alcoholism; Alprazolam; Anxiety Disorders; Benzodiazepines; Clinical Trials | 1981 |
Double-blind study of alprazolam, diazepam, clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Alprazolam; Blood Pressure; Clonidine; Diazepam; Dou | 1994 |
Alterations in pharmacodynamics of anxiolytics in abstinent alcoholic men: subjective responses, abuse liability, and electroencephalographic effects of alprazolam, diazepam, and buspirone.
Topics: Adult; Affect; Alcoholism; Alprazolam; Anti-Anxiety Agents; Buspirone; Diazepam; Electrocardiography | 1997 |
Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism.
Topics: Adult; Affect; Alcoholism; Alprazolam; Anti-Anxiety Agents; Brain; Cross-Over Studies; Double-Blind | 1998 |
Decreased EEG sensitivity to alprazolam in subjects with a parental history of alcoholism.
Topics: Adolescent; Adult; Alcoholism; Alprazolam; Electroencephalography; Female; Frontal Lobe; GABA Modula | 2000 |
Increased sensitivity to alprazolam in females with a paternal history of alcoholism.
Topics: Affect; Alcoholism; Alprazolam; Analysis of Variance; Anti-Anxiety Agents; Buspirone; Chi-Square Dis | 2000 |
Alprazolam, amitriptyline, doxepin, and placebo in the treatment of depression.
Topics: Adult; Alcoholism; Alprazolam; Ambulatory Care; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; | 1985 |
15 other studies available for alprazolam and Alcoholism
| Article | Year |
|---|---|
A Medical Review of Fatal High-G U.S. Aerobatic Accidents.
Topics: Accidents, Aviation; Aerospace Medicine; Alcoholism; Alprazolam; Case-Control Studies; Clonidine; Da | 2019 |
Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder.
Topics: Adult; Alcoholism; Alprazolam; Anxiety Disorders; Biomarkers; Biotransformation; Comorbidity; Cytoch | 2020 |
Treatment of comorbid substance use and anxiety disorders: a case study.
Topics: Adult; Alcoholism; Alprazolam; Ambulatory Care; Anti-Anxiety Agents; Anticonvulsants; Cognitive Beha | 2011 |
Concentrations of alprazolam in blood from impaired drivers and forensic autopsies were not much different but showed a high prevalence of co-ingested illicit drugs.
Topics: Age Factors; Alcoholism; Alprazolam; Amphetamine; Anti-Anxiety Agents; Automobile Driving; Crime; Da | 2013 |
Liability to alprazolam abuse in daughters of alcoholics.
Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Alprazolam; Child of Impaired Parents; Disease Suscepti | 1996 |
A naturalistic 6-year follow-up study of patients with panic disorder.
Topics: Adult; Alcoholism; Alprazolam; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Comorbidity; D | 1996 |
Effects of alprazolam on the free-choice ethanol consumption induced by isolation stress in aged rats.
Topics: Aging; Alcohol Drinking; Alcoholism; Alprazolam; Animals; Anti-Anxiety Agents; Disease Models, Anima | 1999 |
Response of schizophrenic patients to benzodiazepines.
Topics: Alcoholism; Alprazolam; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Humans; Schi | 1992 |
Lack of interaction between disulfiram and alprazolam in alcoholic patients.
Topics: Adult; Alcoholism; Alprazolam; Chromatography, High Pressure Liquid; Disulfiram; Drug Interactions; | 1990 |
Alprazolam use and dependence. A retrospective analysis of 30 cases of withdrawal.
Topics: Adult; Aged; Alcoholism; Alprazolam; Female; Humans; Length of Stay; Male; Middle Aged; Retrospectiv | 1990 |
Parental alcoholism as a risk factor in benzodiazepine abuse: a pilot study.
Topics: Adult; Alcohol Drinking; Alcoholism; Alprazolam; Euphoria; Humans; Male; Parents; Pilot Projects; Ri | 1989 |
A fatality involving clomipramine.
Topics: Alcohol Drinking; Alcoholism; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Chromatography, High | 1986 |
Alprazolam dependence in seven patients.
Topics: Adult; Alcoholism; Alprazolam; Anxiety Disorders; Depressive Disorder; Female; Humans; Male; Marijua | 1988 |
Abuse liability and clinical pharmacokinetics of alprazolam in alcoholic men.
Topics: Adult; Alcoholism; Alprazolam; Emotions; Euphoria; Humans; Male; Middle Aged; Personality Inventory; | 1988 |
Alprazolam in treating secondary depression.
Topics: Alcoholism; Alprazolam; Depressive Disorder; Humans; Substance-Related Disorders | 1987 |