alpinumisoflavone has been researched along with Macular-Degeneration* in 1 studies
1 other study(ies) available for alpinumisoflavone and Macular-Degeneration
| Article | Year |
|---|---|
Alpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models.
Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly population. Anti-vascular endothelial growth factor (VEGF) antibody therapy is applicable to neovascularisation of AMD; however, the prevention of fibrosis after anti-VEGF monotherapy is an unmet medical need. Subretinal fibrosis causes vision loss in neovascular age-related macular degeneration (nAMD) even with anti-VEGF therapy. We report the anti-fibrotic and anti-neovascularisation effects of alpinumisoflavone (AIF), an isoflavonoid derived from unripe Maclura tricuspidata fruit, in in vitro and in vivo models. For in vitro study, we treated H Topics: Animals; Choroidal Neovascularization; Humans; Hydrogen Peroxide; Isoflavones; Macular Degeneration; Mice; Vascular Endothelial Growth Factors | 2022 |