Compounds > alpidem
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alpidem and Acute Liver Injury, Drug-Induced

alpidem has been researched along with Acute Liver Injury, Drug-Induced in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (33.33)18.2507
2000's0 (0.00)29.6817
2010's9 (60.00)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Norman, BH1
Bas, V; Baty, V; Bigard, MA; Boissel, P; Denis, B; Gaucher, P; Goudot, C; Renkes, P1
Ausset, P; Dumas, F; Le Bail, B; Malavialle, P; Miremont, G; Saric, J; Vallet, A; Winnock, S1
Glikmanas, M; Prat, B; Weiss, AM1
Barki, J; Gineston, JL; Lamblin, G; Larrey, D; Michel, H; Pageaux, G1
Balabaud, C; Bernard, PH; Bioulac-Sage, P; Carles, J; Fawaz, R; Le Bail, B; Rosenbaum, J1

Reviews

2 review(s) available for alpidem and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies.
    Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20

    Topics: Animals; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Discovery; Drug Evaluation, Preclinical; Hepatocytes; Humans; Liver; Mitochondria, Liver; Pharmaceutical Preparations; Risk Assessment; Tissue Distribution

2020

Other Studies

13 other study(ies) available for alpidem and Acute Liver Injury, Drug-Induced

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2014
[Hepatitis induced by alpidem (Ananxyl). Four cases, one of them fatal].
    Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:12

    Topics: Adult; Anti-Anxiety Agents; Chemical and Drug Induced Liver Injury; Depressive Disorder; Fatal Outcome; Female; Humans; Imidazoles; Male; Middle Aged; Pyridines

1994
[Subfulminant hepatitis caused by alpidem and treated by liver transplantation].
    Gastroenterologie clinique et biologique, 1995, Volume: 19, Issue:2

    Topics: Antidepressive Agents; Chemical and Drug Induced Liver Injury; Depressive Disorder; Female; Humans; Imidazoles; Liver Function Tests; Liver Transplantation; Middle Aged; Pyridines

1995
[A new case of hepatitis after alpidem monotherapy].
    Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:10

    Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Humans; Imidazoles; Male; Pyridines

1994
[Fatal subfulminant hepatitis during treatment with alpidem (Ananxyl)].
    Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:11

    Topics: Aged; Anti-Anxiety Agents; Anxiety Disorders; Asthenia; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Humans; Imidazoles; Liver Function Tests; Pyridines

1993
Morphology of hepatic stellate cells in patients with fulminant or subfulminant hepatitis requiring liver transplantation.
    Journal of submicroscopic cytology and pathology, 1996, Volume: 28, Issue:1

    Topics: Acetaminophen; Actins; Adult; Aged; Amanita; Autoimmune Diseases; Biomarkers; Cell Differentiation; Chemical and Drug Induced Liver Injury; Extracellular Matrix Proteins; Female; Hepatic Encephalopathy; Hepatitis; Hepatitis, Viral, Human; Humans; Imidazoles; Lipids; Liver; Liver Cirrhosis; Liver Transplantation; Male; Microscopy, Electron; Middle Aged; Muscle, Smooth, Vascular; Mushroom Poisoning; Necrosis; Organelles; Pyridines

1996