alpha-msh has been researched along with Melanoma* in 3 studies
3 other study(ies) available for alpha-msh and Melanoma
| Article | Year |
|---|---|
Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY.
A class of flavanone was found to improve melanogenesis in B16F10 mouse melanoma cell line, but little is known about its target. Herein we described the synthesis and bioevaluation of sixteen 3',4',7-trihydroxyflavanone analogues and further synthesized a novel fluorescent flavanone-BODIPY, which could improve melanogenesis in B16F10 cell line by selectively binding to its endoplasmic reticulum. The fluorescent flavanone-BODIPY was proved to be a valuable probe for studying the localization of intracellular flavanone on living cells. Topics: Animals; Boron Compounds; Cell Line, Tumor; Endoplasmic Reticulum; Flavanones; Fluorescent Dyes; Melanoma; Mice; Mice, Inbred C57BL; Porphobilinogen | 2015 |
Comparative biological activities of highly potent active-site analogues of alpha-melanotropin.
Topics: Adenylyl Cyclases; Amino Acids; Animals; Chemical Phenomena; Chemistry, Physical; Lizards; Melanocyte-Stimulating Hormones; Melanoma; Rana pipiens; Skin; Skin Pigmentation; Time Factors | 1982 |
Synthesis and structure-function studies of melanocyte stimulating hormone analogues modified in the 2 and 4(7) positions: comparison of activities on frog skin melanophores and melanoma adenylate cyclase.
The synthesis and purification of several analogues of the melanotropins with amino acid substitutions at the tyrosine-2 and methionine-4(7) positions are reported. The compounds synthesized included [4-norleucine]-alpha-MSH, [7-norleucine]-beta p-MSH, [2-3',5'-diiodotyrosine]-alpha-MSH, [2-D-tyrosine]-alpha-MSH, and [2-phenylalanine,4-norleucine]-alpha-MSH. The biological activities of these derivatives were measured and compared on normal melanocytes (frog skins) and on transformed melanocytes (mouse melanoma adenylate cyclase), over the entire dose-response range. All compounds tested were full agonists in both assay systems but varied considerably in potency. The relative potencies in the frog skin assay (alpha-MSH = 1.0) were as follows: [Nle7]-beta p-MSH (5.2) > [Nle4]-alpha-MSH (2.3) > alpha-MSH (1.0) > [Phe2,Nle4]-alpha-MSH (0.80) > beta p-MSH (0.55) > [I2-Tyr2]-alpha-MSH (0.12) > [D-Tyr2]-alpha-MSH (0.04). The relative potencies in the melanoma adenylate cyclase system were [Nle7]-beta p-MSH (4.2) > beta p-MSH (2.2) > [Nle4]-alpha-MSH (2.0) > alpha-MSH (1.0) approximately equal to [Phe2,Nle4]-alpha-MSH (0.9) > [I2-Tyr2]-alpha-MSH (0.40) > [D-Tyr2]-alpha-MSH (0.20). There appears to be some differences in structural specificity at the melanotropin receptors of the two cell systems. Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Melanocyte-Stimulating Hormones; Melanoma; Melanophores; Neoplasms, Experimental; Ranidae; Skin | 1980 |