alpha-methylhistamine has been researched along with Disease Models, Animal in 7 studies
alpha-methylhistamine: a histamine H3 receptor agonist; RN given refers to parent cpd without isomeric designation
alpha-methylhistamine : An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol is a short-acting, intravenous general anesthetic that is widely used in clinical practice for short procedures; however, it causes depressed cognitive function for several hours thereafter." | 5.40 | (R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats. ( Cheng, LZ; Li, WW; Raya, AD; Shi, XY; Tian, ML; Wang, Y; Zhang, H; Zou, Z, 2014) |
| " Therefore, H3Rs may have implications for the treatment of degenerative disorders associated with impaired memory function and may represent a novel therapeutic pharmacological target to tackle cognitive problems associated with the chronic use of antiepileptic drugs." | 1.43 | Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats. ( Kieć-Kononowiczc, K; Saad, A; Sadek, B; Shafiullah, M; Subramanian, D; Łażewska, D, 2016) |
| "The study investigated the effect of subchronic dosing (once daily, 7 days) of histamine H3 receptor (H3R) antagonists, ciproxifan (CPX) (3 mg/kg, i." | 1.43 | Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801. ( Akhtar, M; Goswami, D; Jahan, K; Mahmood, D, 2016) |
| "Propofol is a short-acting, intravenous general anesthetic that is widely used in clinical practice for short procedures; however, it causes depressed cognitive function for several hours thereafter." | 1.40 | (R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats. ( Cheng, LZ; Li, WW; Raya, AD; Shi, XY; Tian, ML; Wang, Y; Zhang, H; Zou, Z, 2014) |
| "In amygdaloid kindled seizures, electrodes were implanted into the right amygdala and electroencephalogram was recorded bipolarly; stimulation was applied bipolarly every day by a constant current stimulator and continued until a generalized convulsion was obtained." | 1.32 | Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia. ( Fujii, Y; Harada, C; Harusawa, S; Hirai, T; Kamei, C; Kurihara, T, 2004) |
| "Pre-treatment with thioperamide augmented (p < 0." | 1.29 | Histamine forming capacity (HFC) and its modulation by H3 receptor ligands in a model of bronchial hyper-responsiveness. ( Allen, MC; Graham, P; Morris, G, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, WW | 1 |
| Cheng, LZ | 1 |
| Zou, Z | 1 |
| Tian, ML | 1 |
| Zhang, H | 1 |
| Raya, AD | 1 |
| Wang, Y | 1 |
| Shi, XY | 1 |
| Sadek, B | 1 |
| Saad, A | 1 |
| Subramanian, D | 1 |
| Shafiullah, M | 1 |
| Łażewska, D | 1 |
| Kieć-Kononowiczc, K | 1 |
| Mahmood, D | 1 |
| Akhtar, M | 1 |
| Jahan, K | 1 |
| Goswami, D | 1 |
| Harada, C | 1 |
| Hirai, T | 1 |
| Fujii, Y | 1 |
| Harusawa, S | 1 |
| Kurihara, T | 1 |
| Kamei, C | 1 |
| Francis, H | 1 |
| Franchitto, A | 1 |
| Ueno, Y | 1 |
| Glaser, S | 1 |
| DeMorrow, S | 1 |
| Venter, J | 1 |
| Gaudio, E | 1 |
| Alvaro, D | 1 |
| Fava, G | 1 |
| Marzioni, M | 1 |
| Vaculin, B | 1 |
| Alpini, G | 1 |
| Allen, MC | 1 |
| Graham, P | 1 |
| Morris, G | 1 |
| Pérez-García, C | 1 |
| Morales, L | 1 |
| Cano, MV | 1 |
| Sancho, I | 1 |
| Alguacil, LF | 1 |
7 other studies available for alpha-methylhistamine and Disease Models, Animal
| Article | Year |
|---|---|
(R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats.
Topics: Action Potentials; Amnesia; Anesthetics, Intravenous; Animals; CA1 Region, Hippocampal; Disease Mode | 2014 |
Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzothiazoles; Disease Models, Animal; Dose-Response | 2016 |
Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Histam | 2016 |
Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia.
Topics: Amygdala; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; | 2004 |
H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway.
Topics: Animals; Bile Ducts; Bile Ducts, Intrahepatic; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent | 2007 |
Histamine forming capacity (HFC) and its modulation by H3 receptor ligands in a model of bronchial hyper-responsiveness.
Topics: Animals; Binding Sites; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response Relationshi | 1996 |
Effects of histamine H3 receptor ligands in experimental models of anxiety and depression.
Topics: Analysis of Variance; Animals; Anxiety; Depression; Disease Models, Animal; Histamine Agonists; Hist | 1999 |