alpha-methylhistamine has been researched along with Asthma in 5 studies
alpha-methylhistamine: a histamine H3 receptor agonist; RN given refers to parent cpd without isomeric designation
alpha-methylhistamine : An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since neural bronchoconstriction may be important in asthma we have studied the effect of a specific H3-receptor agonist R-alpha-methylhistamine (alpha MeHA) on bronchoconstriction induced by the inhaled irritant sodium metabisulphite (MBS) in six mild asthmatic subjects in a randomised double-blind crossover study." | 5.07 | Effect of an inhaled histamine H3-receptor agonist on airway responses to sodium metabisulphite in asthma. ( Barnes, PJ; Lecomte, JM; O'Connor, BJ, 1993) |
| "To investigate the effect of selective H3 receptor agonist(R)-alpha-methylhistamine and antagonist thioperamide on the respiratory response in asthmatic guinea pigs respectively." | 3.73 | [The effect of central histamine H3 receptor on breathing activity of asthmatic guinea pigs]. ( Dong, R; Lu, BS; Zhang, M, 2006) |
| "High levels of histamine can be found in the airways of asthma patients." | 3.70 | Histamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood. ( Bast, A; Bruinier, B; Hol, BE; Jansen, HM; Krouwels, FH; Lutter, R; Out, TA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, R | 1 |
| Zhang, M | 1 |
| Lu, BS | 1 |
| Raible, DG | 1 |
| Lenahan, T | 1 |
| Fayvilevich, Y | 1 |
| Kosinski, R | 1 |
| Schulman, ES | 1 |
| O'Connor, BJ | 1 |
| Lecomte, JM | 1 |
| Barnes, PJ | 1 |
| Tamaoki, J | 1 |
| Nakata, J | 1 |
| Takeyama, K | 1 |
| Chiyotani, A | 1 |
| Konno, K | 1 |
| Krouwels, FH | 1 |
| Hol, BE | 1 |
| Lutter, R | 1 |
| Bruinier, B | 1 |
| Bast, A | 1 |
| Jansen, HM | 1 |
| Out, TA | 1 |
1 trial available for alpha-methylhistamine and Asthma
| Article | Year |
|---|---|
Effect of an inhaled histamine H3-receptor agonist on airway responses to sodium metabisulphite in asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Histami | 1993 |
4 other studies available for alpha-methylhistamine and Asthma
| Article | Year |
|---|---|
[The effect of central histamine H3 receptor on breathing activity of asthmatic guinea pigs].
Topics: Animals; Asthma; Brain; Guinea Pigs; Histamine Agonists; Histamine H3 Antagonists; Lateral Ventricle | 2006 |
Pharmacologic characterization of a novel histamine receptor on human eosinophils.
Topics: Acute Disease; Anticonvulsants; Asthma; Burimamide; Calcium; Eosinophils; Fura-2; Histamine Agonists | 1994 |
Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes.
Topics: Amine Oxidase (Copper-Containing); Animals; Asthma; Cimetidine; Dimaprit; Dose-Response Relationship | 1997 |
Histamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchoalveolar Lavage Fluid; Clone | 1998 |