alpha-hydroxyglutarate has been researched along with Seizures in 4 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uncontrolled seizures in patients with gliomas have a significant impact on quality of life and morbidity, yet the mechanisms through which these tumors cause seizures remain unknown." | 1.72 | IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation. ( Bachani, M; Dowdy, T; Fayed, I; Gilbert, M; Inati, SK; Jahanipour, J; Khan, A; Ksendzovsky, A; Larion, M; Maric, D; Mortazavi, A; Owotade, J; Steiner, J; Walbridge, S; Wu, J; Yang, CZ; Zaghloul, KA, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mortazavi, A | 1 |
| Fayed, I | 1 |
| Bachani, M | 1 |
| Dowdy, T | 1 |
| Jahanipour, J | 1 |
| Khan, A | 1 |
| Owotade, J | 1 |
| Walbridge, S | 1 |
| Inati, SK | 1 |
| Steiner, J | 1 |
| Wu, J | 1 |
| Gilbert, M | 1 |
| Yang, CZ | 1 |
| Larion, M | 1 |
| Maric, D | 1 |
| Ksendzovsky, A | 1 |
| Zaghloul, KA | 1 |
| Saidha, S | 1 |
| Murphy, S | 1 |
| McCarthy, P | 1 |
| Mayne, PD | 1 |
| Hennessy, M | 1 |
| Read, MH | 1 |
| Bonamy, C | 1 |
| Laloum, D | 1 |
| Belloy, F | 1 |
| Constans, JM | 1 |
| Guillois, B | 1 |
| Kottler, ML | 1 |
| Verhoeven, NM | 1 |
| Jakobs, C | 1 |
| Baker, NS | 1 |
| Sarnat, HB | 1 |
| Jack, RM | 1 |
| Patterson, K | 1 |
| Shaw, DW | 1 |
| Herndon, SP | 1 |
4 other studies available for alpha-hydroxyglutarate and Seizures
| Article | Year |
|---|---|
IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation; Quality of Life; Se | 2022 |
L-2-hydroxyglutaric aciduria diagnosed in an adult presenting with acute deterioration.
Topics: Adult; Ataxia; Brain; Disease Progression; Epilepsy; Glutarates; Humans; Lysine; Male; Metabolism, I | 2010 |
Clinical, biochemical, magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) findings in a fourth case of combined D- and L-2 hydroxyglutaric aciduria.
Topics: Brain; Brain Diseases, Metabolic, Inborn; Cysts; Electroencephalography; Fatal Outcome; Female; Fuma | 2005 |
D-2-hydroxyglutaric aciduria: hypotonia, cortical blindness, seizures, cardiomyopathy, and cylindrical spirals in skeletal muscle.
Topics: Amino Acid Metabolism, Inborn Errors; Blindness; Brain Diseases; Cardiomyopathies; Electroencephalog | 1997 |