alpha-hydroxyglutarate has been researched along with Metastase in 3 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Excerpt | Relevance | Reference |
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" Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples." | 4.02 | PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1. ( Bugide, S; Della Manna, D; Gupta, R; Malvi, P; Rawat, V; Wajapeyee, N; Yang, ES; Zhang, X, 2021) |
" Here, we find in colorectal cancer cells that even in the absence of IDH mutation, the levels of D-2HG and its enantiomer L-2HG were elevated through glutamine anaplerosis." | 3.83 | Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. ( Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K, 2016) |
"Here, we find in colorectal cancer cells that even in the absence of IDH mutation, the levels of D-2HG and its enantiomer L-2HG were elevated through glutamine anaplerosis." | 1.43 | Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. ( Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K, 2016) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (66.67) | 24.3611 |
2020's | 1 (33.33) | 2.80 |
Authors | Studies |
---|---|
Rawat, V | 1 |
Malvi, P | 1 |
Della Manna, D | 1 |
Yang, ES | 1 |
Bugide, S | 1 |
Zhang, X | 1 |
Gupta, R | 1 |
Wajapeyee, N | 1 |
Saha, SK | 1 |
Parachoniak, CA | 1 |
Ghanta, KS | 1 |
Fitamant, J | 1 |
Ross, KN | 1 |
Najem, MS | 1 |
Gurumurthy, S | 1 |
Akbay, EA | 1 |
Sia, D | 1 |
Cornella, H | 1 |
Miltiadous, O | 1 |
Walesky, C | 1 |
Deshpande, V | 1 |
Zhu, AX | 1 |
Hezel, AF | 1 |
Yen, KE | 1 |
Straley, KS | 1 |
Travins, J | 1 |
Popovici-Muller, J | 1 |
Gliser, C | 1 |
Ferrone, CR | 1 |
Apte, U | 1 |
Llovet, JM | 1 |
Wong, KK | 1 |
Ramaswamy, S | 1 |
Bardeesy, N | 1 |
Colvin, H | 1 |
Nishida, N | 1 |
Konno, M | 1 |
Haraguchi, N | 1 |
Takahashi, H | 1 |
Nishimura, J | 1 |
Hata, T | 1 |
Kawamoto, K | 1 |
Asai, A | 1 |
Tsunekuni, K | 1 |
Koseki, J | 1 |
Mizushima, T | 1 |
Satoh, T | 1 |
Doki, Y | 1 |
Mori, M | 1 |
Ishii, H | 1 |
3 other studies available for alpha-hydroxyglutarate and Metastase
Article | Year |
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PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdow | 2021 |
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Differentiation; Cell Division; Cell Li | 2014 |
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer.
Topics: Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Glutamine; | 2016 |