Page last updated: 2024-10-15

alpha-hydroxyglutarate and Metastase

alpha-hydroxyglutarate has been researched along with Metastase in 3 studies

2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
" Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples."4.02PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1. ( Bugide, S; Della Manna, D; Gupta, R; Malvi, P; Rawat, V; Wajapeyee, N; Yang, ES; Zhang, X, 2021)
" Here, we find in colorectal cancer cells that even in the absence of IDH mutation, the levels of D-2HG and its enantiomer L-2HG were elevated through glutamine anaplerosis."3.83Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. ( Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K, 2016)
"Here, we find in colorectal cancer cells that even in the absence of IDH mutation, the levels of D-2HG and its enantiomer L-2HG were elevated through glutamine anaplerosis."1.43Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. ( Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K, 2016)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Rawat, V1
Malvi, P1
Della Manna, D1
Yang, ES1
Bugide, S1
Zhang, X1
Gupta, R1
Wajapeyee, N1
Saha, SK1
Parachoniak, CA1
Ghanta, KS1
Fitamant, J1
Ross, KN1
Najem, MS1
Gurumurthy, S1
Akbay, EA1
Sia, D1
Cornella, H1
Miltiadous, O1
Walesky, C1
Deshpande, V1
Zhu, AX1
Hezel, AF1
Yen, KE1
Straley, KS1
Travins, J1
Popovici-Muller, J1
Gliser, C1
Ferrone, CR1
Apte, U1
Llovet, JM1
Wong, KK1
Ramaswamy, S1
Bardeesy, N1
Colvin, H1
Nishida, N1
Konno, M1
Haraguchi, N1
Takahashi, H1
Nishimura, J1
Hata, T1
Kawamoto, K1
Asai, A1
Tsunekuni, K1
Koseki, J1
Mizushima, T1
Satoh, T1
Doki, Y1
Mori, M1
Ishii, H1

Other Studies

3 other studies available for alpha-hydroxyglutarate and Metastase

ArticleYear
PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
    Oncogene, 2021, Volume: 40, Issue:13

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdow

2021
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
    Nature, 2014, Sep-04, Volume: 513, Issue:7516

    Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Differentiation; Cell Division; Cell Li

2014
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer.
    Scientific reports, 2016, 11-08, Volume: 6

    Topics: Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Glutamine;

2016