alpha-hydroxyglutarate has been researched along with Metastase in 3 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples." | 4.02 | PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1. ( Bugide, S; Della Manna, D; Gupta, R; Malvi, P; Rawat, V; Wajapeyee, N; Yang, ES; Zhang, X, 2021) |
| " Here, we find in colorectal cancer cells that even in the absence of IDH mutation, the levels of D-2HG and its enantiomer L-2HG were elevated through glutamine anaplerosis." | 3.83 | Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. ( Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K, 2016) |
| "Here, we find in colorectal cancer cells that even in the absence of IDH mutation, the levels of D-2HG and its enantiomer L-2HG were elevated through glutamine anaplerosis." | 1.43 | Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. ( Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Rawat, V | 1 |
| Malvi, P | 1 |
| Della Manna, D | 1 |
| Yang, ES | 1 |
| Bugide, S | 1 |
| Zhang, X | 1 |
| Gupta, R | 1 |
| Wajapeyee, N | 1 |
| Saha, SK | 1 |
| Parachoniak, CA | 1 |
| Ghanta, KS | 1 |
| Fitamant, J | 1 |
| Ross, KN | 1 |
| Najem, MS | 1 |
| Gurumurthy, S | 1 |
| Akbay, EA | 1 |
| Sia, D | 1 |
| Cornella, H | 1 |
| Miltiadous, O | 1 |
| Walesky, C | 1 |
| Deshpande, V | 1 |
| Zhu, AX | 1 |
| Hezel, AF | 1 |
| Yen, KE | 1 |
| Straley, KS | 1 |
| Travins, J | 1 |
| Popovici-Muller, J | 1 |
| Gliser, C | 1 |
| Ferrone, CR | 1 |
| Apte, U | 1 |
| Llovet, JM | 1 |
| Wong, KK | 1 |
| Ramaswamy, S | 1 |
| Bardeesy, N | 1 |
| Colvin, H | 1 |
| Nishida, N | 1 |
| Konno, M | 1 |
| Haraguchi, N | 1 |
| Takahashi, H | 1 |
| Nishimura, J | 1 |
| Hata, T | 1 |
| Kawamoto, K | 1 |
| Asai, A | 1 |
| Tsunekuni, K | 1 |
| Koseki, J | 1 |
| Mizushima, T | 1 |
| Satoh, T | 1 |
| Doki, Y | 1 |
| Mori, M | 1 |
| Ishii, H | 1 |
3 other studies available for alpha-hydroxyglutarate and Metastase
| Article | Year |
|---|---|
PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdow | 2021 |
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Differentiation; Cell Division; Cell Li | 2014 |
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer.
Topics: Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Glutamine; | 2016 |