alpha-hydroxyglutarate has been researched along with Leucocythaemia in 5 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute leukemias are clonal disorders of hematopoiesis wherein a leukemic stem cell (LSC) acquires mutations that confer the capacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferation to the leukemic clone." | 1.36 | Metabolism and the leukemic stem cell. ( Abdel-Wahab, O; Levine, RL, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McKenney, AS | 1 |
| Levine, RL | 2 |
| Reitman, ZJ | 1 |
| Sinenko, SA | 1 |
| Spana, EP | 1 |
| Yan, H | 1 |
| Fiehn, O | 1 |
| Showalter, MR | 1 |
| Schaner-Tooley, CE | 1 |
| Abdel-Wahab, O | 1 |
| Losman, JA | 1 |
| Looper, RE | 1 |
| Koivunen, P | 1 |
| Lee, S | 1 |
| Schneider, RK | 1 |
| McMahon, C | 1 |
| Cowley, GS | 1 |
| Root, DE | 1 |
| Ebert, BL | 1 |
| Kaelin, WG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence, Correlation With Other Mutant Genes and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia. The European IDH Research Alliance[NCT04369287] | 654 participants (Anticipated) | Observational | 2016-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alpha-hydroxyglutarate and Leucocythaemia
| Article | Year |
|---|---|
Isocitrate dehydrogenase mutations in leukemia.
Topics: Animals; Biomarkers, Tumor; Dioxygenases; DNA Mutational Analysis; DNA-Binding Proteins; Glutarates; | 2013 |
4 other studies available for alpha-hydroxyglutarate and Leucocythaemia
| Article | Year |
|---|---|
Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Glutarates; | 2015 |
Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Topics: Glutarates; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Leukemia; Mutation | 2016 |
Metabolism and the leukemic stem cell.
Topics: Animals; Cholecalciferol; Glutarates; Hematopoiesis; Hematopoietic Stem Cells; Humans; Hypoxia-Induc | 2010 |
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Glutarates; Hematopoiesis; Humans; Isocitrate Deh | 2013 |