alpha-hydroxyglutarate has been researched along with Hematologic Malignancies in 4 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Across glioma as well as several hematologic malignancies, mutations in IDH1 and IDH2 have shown prognostic value." | 2.46 | Cancer-associated IDH mutations: biomarker and therapeutic opportunities. ( Bittinger, MA; Fantin, VR; Su, SM; Yen, KE, 2010) |
| "Hematologic malignancies are frequently associated with cardiac pathologies." | 1.43 | Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. ( Goodell, MA; Harmancey, R; Karlstaedt, A; Taegtmeyer, H; Vasquez, H; Vitrac, H; Wang, JH; Zhang, X, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rakheja, D | 1 |
| Fuda, F | 1 |
| Vandergriff, T | 1 |
| Boriack, R | 1 |
| Medeiros, BC | 1 |
| Frankel, AE | 1 |
| Chen, W | 1 |
| Heuser, M | 1 |
| Araujo Cruz, MM | 1 |
| Goparaju, R | 1 |
| Chaturvedi, A | 1 |
| Karlstaedt, A | 1 |
| Zhang, X | 1 |
| Vitrac, H | 1 |
| Harmancey, R | 1 |
| Vasquez, H | 1 |
| Wang, JH | 1 |
| Goodell, MA | 1 |
| Taegtmeyer, H | 1 |
| Yen, KE | 1 |
| Bittinger, MA | 1 |
| Su, SM | 1 |
| Fantin, VR | 1 |
2 reviews available for alpha-hydroxyglutarate and Hematologic Malignancies
| Article | Year |
|---|---|
Enigmas of IDH mutations in hematology/oncology.
Topics: Animals; DNA Methylation; Enzyme Inhibitors; Glutarates; Hematologic Neoplasms; Humans; Isocitrate D | 2015 |
Cancer-associated IDH mutations: biomarker and therapeutic opportunities.
Topics: Biomarkers, Tumor; Central Nervous System Neoplasms; Glioma; Glutarates; Hematologic Neoplasms; Huma | 2010 |
2 other studies available for alpha-hydroxyglutarate and Hematologic Malignancies
| Article | Year |
|---|---|
Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2-mutated blastic plasmacytoid dendritic cell neoplasm.
Topics: Aged; Dendritic Cells; Female; Glutarates; Hematologic Neoplasms; Humans; Isocitrate Dehydrogenase; | 2015 |
Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.
Topics: Acetylation; Animals; ATP Citrate (pro-S)-Lyase; Cardiomyopathies; Glutarates; Hematologic Neoplasms | 2016 |