alpha-hydroxyglutarate has been researched along with Glioma in 120 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Lithium chloride was recently proved efficient in inhibiting glioma cell migration." | 7.80 | Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β. ( Chan, KG; Fu, Y; Hu, F; Liang, A; Zheng, Y, 2014) |
| "Lithium chloride was recently proved efficient in inhibiting glioma cell migration." | 5.40 | Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β. ( Chan, KG; Fu, Y; Hu, F; Liang, A; Zheng, Y, 2014) |
| "Previous ex vivo spectroscopic data from tissue samples revealed differences in phospholipid metabolites between isocitrate dehydrogenase mutated (IDHmut) and IDH wildtype (IDHwt) gliomas." | 3.91 | In vivo Metabolic Profiles as Determined by ( Bähr, O; Franz, K; Hattingen, E; Pilatus, U; Steinbach, J; Wenger, KJ, 2019) |
| " However, in isocitrate dehydrogenase (IDH)-mutant gliomas, (13)C labeling is obscured in oncometabolite 2-hydroxyglutaric acid (2 HG) by glutamate and glutamine, prompting development of a simple method to resolve the metabolites." | 3.81 | Conditions for (13)C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas. ( Bachoo, RM; Baek, HM; DeBerardinis, RJ; Kovacs, Z; Maher, EA; Malloy, CR; Mashimo, T; Mickey, B; Pichumani, K; Ratnakar, J, 2015) |
| " Lithium chloride was recently proved efficient in inhibiting glioma cell migration." | 3.80 | Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β. ( Chan, KG; Fu, Y; Hu, F; Liang, A; Zheng, Y, 2014) |
| "Mixed oligoastrocytoma is losing popularity as a diagnostic term because most cases will fall into either the FA or OD category." | 2.52 | Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas. ( Macaulay, RJ, 2015) |
| "Across glioma as well as several hematologic malignancies, mutations in IDH1 and IDH2 have shown prognostic value." | 2.46 | Cancer-associated IDH mutations: biomarker and therapeutic opportunities. ( Bittinger, MA; Fantin, VR; Su, SM; Yen, KE, 2010) |
| "Cancer cachexia is characterized by weight loss and skeletal muscle wasting." | 1.91 | Oncometabolite D-2-hydroxyglutarate-dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia. ( Cheng, D; Chi, M; Ding, J; Guo, C; Hao, J; Huang, J; Sun, X; Wang, Y; Xin, B; Xincai, Z; Xu, R; Yang, Q; Yuan, T; Zhang, H; Zhang, J; Zheng, S; Zhou, S; Zhu, X, 2023) |
| "Uncontrolled seizures in patients with gliomas have a significant impact on quality of life and morbidity, yet the mechanisms through which these tumors cause seizures remain unknown." | 1.72 | IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation. ( Bachani, M; Dowdy, T; Fayed, I; Gilbert, M; Inati, SK; Jahanipour, J; Khan, A; Ksendzovsky, A; Larion, M; Maric, D; Mortazavi, A; Owotade, J; Steiner, J; Walbridge, S; Wu, J; Yang, CZ; Zaghloul, KA, 2022) |
| "Lower grade mIDH1 gliomas are classified into 2 molecular subgroups: 1p/19q codeletion/TERT-promoter mutations or inactivating mutations in α-thalassemia/mental retardation syndrome X-linked (ATRX) and TP53." | 1.62 | Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice. ( Alghamri, MS; Appelman, H; Carney, SV; Castro, MG; Edwards, MB; Garcia-Fabiani, MB; Gauss, JC; Haase, S; Kadiyala, P; Kleer, CG; Li, D; Liu, Y; Lowenstein, PR; Moon, JJ; Núñez, FJ; Nunez, FM; Schwendeman, A; Sun, Y; Taher, A; Yu, M; Zhao, L, 2021) |
| "The sensitivity and specificity was 89." | 1.48 | Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting. ( Choi, C; Lassen-Ramshad, Y; Lukacova, S; Maher, EA; Mickey, B; Parm Ulhøi, B; Sangill, R; Tietze, A; von Oettingen, G; Østergaard, L, 2018) |
| "Eighteen patients with brain tumors of probable glial origin participated in this study." | 1.43 | MR spectroscopy for in vivo assessment of the oncometabolite 2-hydroxyglutarate and its effects on cellular metabolism in human brain gliomas at 9.4T. ( Bisdas, S; Braun, C; Chadzynski, GL; Engelmann, J; Ernemann, U; Ethofer, T; Hagberg, GE; Pohmann, R; Scheffler, K; Schittenhelm, J; Shajan, G; Skardelly, M; Tabatabai, G; Ziemann, U, 2016) |
| "Lithium chloride was recently proved efficient in inhibiting glioma cell migration." | 1.40 | Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β. ( Chan, KG; Fu, Y; Hu, F; Liang, A; Zheng, Y, 2014) |
| "Patients with intrinsic glial brain tumors (n = 27) underwent structural and spectroscopic magnetic resonance imaging prior to surgery." | 1.38 | Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. ( Albert Thomas, M; Bittinger, MA; Chou, AP; Cloughesy, TF; Driggers, E; Fantin, VR; Jang, HG; Kornblum, HI; Lai, A; Liau, LM; Nagarajan, R; Pope, WB; Prins, RM; Salamon, N; Schenkein, DP; Soto, H; Su, SM; Wilson, N; Wu, H; Yen, KE; Yong, WH, 2012) |
| "Gliomas were found to have elevated levels of similar histone repressive marks." | 1.38 | IDH mutation impairs histone demethylation and results in a block to cell differentiation. ( Abdel-Wahab, O; Berger, SL; Chan, TA; Edwards, CR; Figueroa, ME; Kapoor, GS; Khanin, R; Levine, RL; Lu, C; Mellinghoff, IK; Melnick, A; O'Rourke, DM; Rohle, D; Thompson, CB; Turcan, S; Ward, PS; Wellen, KE, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (0.83) | 29.6817 |
| 2010's | 90 (75.00) | 24.3611 |
| 2020's | 29 (24.17) | 2.80 |
| Authors | Studies |
|---|---|
| Chou, FJ | 1 |
| Liu, Y | 6 |
| Lang, F | 1 |
| Yang, C | 2 |
| Juskanič, D | 1 |
| Mištinová, JP | 1 |
| Hollý, S | 1 |
| Sekerešová, M | 1 |
| Koleják, K | 1 |
| Pátrovič, L | 1 |
| Mortazavi, A | 1 |
| Fayed, I | 1 |
| Bachani, M | 1 |
| Dowdy, T | 1 |
| Jahanipour, J | 1 |
| Khan, A | 1 |
| Owotade, J | 1 |
| Walbridge, S | 1 |
| Inati, SK | 1 |
| Steiner, J | 1 |
| Wu, J | 2 |
| Gilbert, M | 1 |
| Yang, CZ | 1 |
| Larion, M | 1 |
| Maric, D | 1 |
| Ksendzovsky, A | 1 |
| Zaghloul, KA | 1 |
| Winkler, F | 1 |
| Tuna, G | 1 |
| Dal-Bekar, NE | 1 |
| Akay, A | 1 |
| Rükşen, M | 1 |
| İşlekel, S | 1 |
| İşlekel, GH | 1 |
| Chuntova, P | 1 |
| Yamamichi, A | 1 |
| Chen, T | 1 |
| Narayanaswamy, R | 1 |
| Ronseaux, S | 1 |
| Hudson, C | 1 |
| Tron, AE | 1 |
| Hyer, ML | 1 |
| Montoya, M | 1 |
| Mende, AL | 1 |
| Nejo, T | 1 |
| Downey, KM | 1 |
| Diebold, D | 1 |
| Lu, M | 2 |
| Nicolay, B | 2 |
| Okada, H | 1 |
| Autry, AW | 1 |
| Lafontaine, M | 1 |
| Jalbert, L | 1 |
| Phillips, E | 1 |
| Phillips, JJ | 5 |
| Villanueva-Meyer, J | 1 |
| Berger, MS | 2 |
| Chang, SM | 3 |
| Li, Y | 2 |
| Fujita, Y | 1 |
| Nunez-Rubiano, L | 1 |
| Dono, A | 1 |
| Bellman, A | 1 |
| Shah, M | 1 |
| Rodriguez, JC | 1 |
| Putluri, V | 1 |
| Kamal, AHM | 1 |
| Putluri, N | 1 |
| Riascos, RF | 1 |
| Zhu, JJ | 1 |
| Esquenazi, Y | 1 |
| Ballester, LY | 1 |
| Di Stefano, AL | 1 |
| Nichelli, L | 1 |
| Berzero, G | 1 |
| Valabregue, R | 1 |
| Touat, M | 1 |
| Capelle, L | 1 |
| Pontoizeau, C | 1 |
| Bielle, F | 1 |
| Lerond, J | 1 |
| Giry, M | 1 |
| Villa, C | 1 |
| Baussart, B | 1 |
| Dehais, C | 1 |
| Galanaud, D | 1 |
| Baldini, C | 1 |
| Savatovsky, J | 1 |
| Dhermain, F | 1 |
| Deelchand, DK | 1 |
| Ottolenghi, C | 1 |
| Lehéricy, S | 1 |
| Marjańska, M | 2 |
| Branzoli, F | 1 |
| Sanson, M | 1 |
| Shi, DD | 2 |
| Anand, S | 1 |
| Abdullah, KG | 1 |
| McBrayer, SK | 3 |
| Afsari, F | 1 |
| McIntyre, TM | 2 |
| Iwahashi, H | 1 |
| Nagashima, H | 2 |
| Tanaka, K | 2 |
| Uno, T | 1 |
| Hashiguchi, M | 1 |
| Maeyama, M | 1 |
| Somiya, Y | 1 |
| Komatsu, M | 1 |
| Hirose, T | 1 |
| Itoh, T | 2 |
| Sasaki, R | 2 |
| Sasayama, T | 2 |
| Gunn, K | 1 |
| Myllykoski, M | 1 |
| Cao, JZ | 1 |
| Ahmed, M | 1 |
| Huang, B | 2 |
| Rouaisnel, B | 1 |
| Diplas, BH | 2 |
| Levitt, MM | 1 |
| Looper, R | 2 |
| Doench, JG | 1 |
| Ligon, KL | 4 |
| Kornblum, HI | 2 |
| Yan, H | 7 |
| Duy, C | 1 |
| Godley, LA | 1 |
| Koivunen, P | 2 |
| Losman, JA | 2 |
| Cao, C | 1 |
| Zhang, L | 1 |
| Sorensen, MD | 1 |
| Reifenberger, G | 1 |
| Kristensen, BW | 1 |
| Lin, F | 3 |
| Zhu, X | 1 |
| Hao, J | 1 |
| Zhang, H | 1 |
| Chi, M | 1 |
| Wang, Y | 1 |
| Huang, J | 1 |
| Xu, R | 1 |
| Xincai, Z | 1 |
| Xin, B | 1 |
| Sun, X | 1 |
| Zhang, J | 4 |
| Zhou, S | 1 |
| Cheng, D | 1 |
| Yuan, T | 1 |
| Ding, J | 1 |
| Zheng, S | 1 |
| Guo, C | 1 |
| Yang, Q | 1 |
| Zhang, Y | 5 |
| Pusch, S | 5 |
| Innes, J | 1 |
| Sidlauskas, K | 1 |
| Ellis, M | 1 |
| Lau, J | 1 |
| El-Hassan, T | 1 |
| Aley, N | 1 |
| Launchbury, F | 1 |
| Richard-Loendt, A | 1 |
| deBoer, J | 1 |
| Chen, S | 1 |
| Wang, L | 4 |
| von Deimling, A | 6 |
| Li, N | 1 |
| Brandner, S | 1 |
| Bhavya, B | 1 |
| Anand, CR | 1 |
| Madhusoodanan, UK | 1 |
| Rajalakshmi, P | 1 |
| Krishnakumar, K | 1 |
| Easwer, HV | 1 |
| Deepti, AN | 1 |
| Gopala, S | 1 |
| Huang, LE | 1 |
| Cuccarini, V | 1 |
| Antelmi, L | 1 |
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| Paterra, R | 1 |
| Calatozzolo, C | 1 |
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| DiMeco, F | 1 |
| Eoli, M | 1 |
| Finocchiaro, G | 3 |
| Brenna, G | 1 |
| Tramacere, I | 1 |
| Bruzzone, MG | 3 |
| Anghileri, E | 2 |
| Karpel-Massler, G | 2 |
| Nguyen, TTT | 1 |
| Shang, E | 1 |
| Siegelin, MD | 2 |
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| Strasser, B | 1 |
| Jafari-Khouzani, K | 2 |
| Thapa, B | 1 |
| Small, J | 1 |
| Cahill, DP | 8 |
| Dietrich, J | 3 |
| Batchelor, TT | 6 |
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| Huang, RY | 2 |
| Lin, A | 1 |
| Tiwari, V | 5 |
| Mashimo, T | 4 |
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| Vemireddy, V | 2 |
| Piccirillo, S | 1 |
| Askari, P | 2 |
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| de Graaf, RA | 2 |
| Patel, TR | 5 |
| Pan, E | 5 |
| Mickey, BE | 6 |
| Maher, EA | 8 |
| Bachoo, RM | 4 |
| Choi, C | 9 |
| Xiong, N | 1 |
| Gao, X | 1 |
| Zhao, H | 1 |
| Cai, F | 1 |
| Zhang, FC | 1 |
| Yuan, Y | 1 |
| Liu, W | 2 |
| He, F | 1 |
| Zacharias, LG | 1 |
| Lin, H | 1 |
| Vu, HS | 1 |
| Xing, C | 1 |
| Yao, DX | 1 |
| Chen, F | 1 |
| Luo, B | 1 |
| Sun, W | 1 |
| DeBerardinis, RJ | 3 |
| Xu, H | 2 |
| Ge, WP | 1 |
| Molloy, AR | 2 |
| Najac, C | 2 |
| Viswanath, P | 5 |
| Lakhani, A | 1 |
| Subramani, E | 2 |
| Batsios, G | 2 |
| Radoul, M | 2 |
| Gillespie, AM | 2 |
| Pieper, RO | 5 |
| Ronen, SM | 6 |
| Bystricky, P | 1 |
| Kasubova, I | 1 |
| Richterova, R | 1 |
| Lasabova, Z | 1 |
| Kolarovszki, B | 1 |
| Thamim, M | 1 |
| Thirumoorthy, K | 1 |
| Waitkus, MS | 2 |
| Kadiyala, P | 1 |
| Carney, SV | 1 |
| Gauss, JC | 1 |
| Garcia-Fabiani, MB | 1 |
| Haase, S | 1 |
| Alghamri, MS | 1 |
| Núñez, FJ | 1 |
| Yu, M | 1 |
| Taher, A | 1 |
| Nunez, FM | 1 |
| Li, D | 1 |
| Edwards, MB | 1 |
| Kleer, CG | 1 |
| Appelman, H | 1 |
| Sun, Y | 1 |
| Zhao, L | 1 |
| Moon, JJ | 1 |
| Schwendeman, A | 1 |
| Lowenstein, PR | 1 |
| Castro, MG | 1 |
| Bhandari, A | 1 |
| Sharma, C | 1 |
| Ibrahim, M | 1 |
| Riggs, M | 1 |
| Jones, R | 1 |
| Lasocki, A | 1 |
| Dimitrov, IE | 1 |
| Ganji, SK | 4 |
| Levy, M | 3 |
| Malloy, CR | 4 |
| Lan, C | 1 |
| Li, H | 1 |
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| Wu, T | 1 |
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| Jezzard, P | 2 |
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| Cadoux-Hudson, T | 2 |
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| Izquierdo-Garcia, JL | 1 |
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| Kriegsmann, M | 1 |
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| Chen, Y | 1 |
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| Rosenblum, MK | 1 |
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| Su, SM | 5 |
| Brennan, CW | 1 |
| Chan, TA | 2 |
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| Yen, KE | 5 |
| Mellinghoff, IK | 3 |
| Ganji, S | 1 |
| Hulsey, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MicroOrganoSphere Drug Screen to Lead Care (MODEL) Precision Oncology Pilot Trial in Colorectal Cancer (CRC)[NCT05189171] | 180 participants (Anticipated) | Observational | 2022-10-25 | Recruiting | |||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| Metabolic Characterization of Space Occupying Lesions of the Brain Using in Vivo MR- (Spectroscopic) Imaging at 3 Tesla and 7 Tesla[NCT04233788] | 55 participants (Anticipated) | Observational | 2021-09-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for alpha-hydroxyglutarate and Glioma
| Article | Year |
|---|---|
D-2-Hydroxyglutarate in Glioma Biology.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Brain Neoplasms; Carcinogenesis; Cell Transformation, | 2021 |
DNA damage in IDH-mutant gliomas: mechanisms and clinical implications.
Topics: Brain Neoplasms; DNA Damage; Glioma; Humans; Isocitrate Dehydrogenase; Mutation | 2023 |
To be Wild or Mutant: Role of Isocitrate Dehydrogenase 1 (IDH1) and 2-Hydroxy Glutarate (2-HG) in Gliomagenesis and Treatment Outcome in Glioma.
Topics: Animals; Carcinogenesis; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation; Treatment O | 2020 |
Friend or foe-IDH1 mutations in glioma 10 years on.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenas | 2019 |
Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies.
Topics: Brain Neoplasms; Clinical Trials as Topic; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; | 2021 |
The role of 2-hydroxyglutarate magnetic resonance spectroscopy for the determination of isocitrate dehydrogenase status in lower grade gliomas versus glioblastoma: a systematic review and meta-analysis of diagnostic test accuracy.
Topics: Brain Neoplasms; Diagnostic Tests, Routine; Glioblastoma; Glioma; Glutarates; Humans; Isocitrate Deh | 2021 |
2-Hydroxyglutarate MR spectroscopy for prediction of isocitrate dehydrogenase mutant glioma: a systemic review and meta-analysis using individual patient data.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spectrosco | 2018 |
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.
Topics: Bile Duct Neoplasms; Bone Neoplasms; Central Nervous System Neoplasms; Cholangiocarcinoma; Chondrosa | 2013 |
Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.
Topics: Biomarkers, Tumor; Brain; Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Mag | 2013 |
Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas.
Topics: Antibodies, Monoclonal; Arginine; Biomarkers, Tumor; Brain Neoplasms; Catalysis; Cytosol; Glioma; Gl | 2015 |
Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas.
Topics: Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; DNA Helicases; Genes, p53; Glioma; Glutarates; Huma | 2015 |
Isocitrate dehydrogenase mutations in gliomas.
Topics: Animals; Brain Neoplasms; Glioblastoma; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Ketogl | 2016 |
2-hydroxyglutarate accumulation caused by IDH mutation is involved in the formation of malignant gliomas.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation | 2010 |
Cancer-associated IDH mutations: biomarker and therapeutic opportunities.
Topics: Biomarkers, Tumor; Central Nervous System Neoplasms; Glioma; Glutarates; Hematologic Neoplasms; Huma | 2010 |
Analysis of isocitrate dehydrogenase-1/2 gene mutations in gliomas.
Topics: Adult; Age Factors; Brain Neoplasms; Genes, p53; Glioma; Glutarates; Humans; Isocitrate Dehydrogenas | 2010 |
3 trials available for alpha-hydroxyglutarate and Glioma
| Article | Year |
|---|---|
Diagnostic accuracy of 2-hydroxyglutarate magnetic resonance spectroscopy in newly diagnosed brain mass and suspected recurrent gliomas.
Topics: Adult; Aged; Brain Neoplasms; Female; Follow-Up Studies; Glioma; Glutarates; Humans; Isocitrate Dehy | 2018 |
Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Drug Administration Schedule; Drug Monitoring; Enzyme | 2018 |
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.
Topics: Brain Neoplasms; Female; Glioma; Glutarates; Humans; Intraoperative Care; Magnetic Resonance Imaging | 2014 |
102 other studies available for alpha-hydroxyglutarate and Glioma
| Article | Year |
|---|---|
Diagnostic performance of edited 2HG MR spectroscopy of central glioma in the clinical environment.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spectrosco | 2022 |
IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation; Quality of Life; Se | 2022 |
Understanding epilepsy in IDH-mutated gliomas: towards a targeted therapy.
Topics: Epilepsy; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; TOR Serine-Threonine Kinases | 2022 |
Minimally Invasive Detection of IDH1 Mutation With Cell-Free Circulating Tumor DNA and D-2-Hydroxyglutarate, D/L-2-Hydroxyglutarate Ratio in Gliomas.
Topics: Brain Neoplasms; Circulating Tumor DNA; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Mutati | 2022 |
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma.
Topics: Animals; Cancer Vaccines; Glioma; Glutarates; HLA-A2 Antigen; HLA-DR1 Antigen; Humans; Immune Checkp | 2022 |
Spectroscopic imaging of D-2-hydroxyglutarate and other metabolites in pre-surgical patients with IDH-mutant lower-grade gliomas.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Inositol; Isocitrate Dehydrogenase; Magnetic Resonance | 2022 |
IDH1 p.R132H ctDNA and D-2-hydroxyglutarate as CSF biomarkers in patients with IDH-mutant gliomas.
Topics: Biomarkers; Brain Neoplasms; Circulating Tumor DNA; Glioma; Glutarates; Humans; Isocitrate Dehydroge | 2022 |
In Vivo 2-Hydroxyglutarate Monitoring With Edited MR Spectroscopy for the Follow-up of
Topics: Brain Neoplasms; Follow-Up Studies; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Magnetic R | 2023 |
D-2-Hydroxyglutarate Inhibits Calcineurin Phosphatase Activity to Abolish NF-AT Activation and IL-2 Induction in Stimulated Lymphocytes.
Topics: Calcineurin; Calcium; Glioma; Humans; Interleukin-2; Jurkat Cells; Lymphocytes | 2023 |
2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma.
Topics: Adult; Brain Neoplasms; Brain Stem Neoplasms; Female; Glioma; Humans; Image-Guided Biopsy; Isocitrat | 2023 |
(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.
Topics: Cell Transformation, Neoplastic; DNA Methylation; Glioma; Glutarates; Histone Demethylases; Histones | 2023 |
D-2-hydroxyglutarate regulates human brain vascular endothelial cell proliferation and barrier function.
Topics: Astrocytoma; Brain; Brain Neoplasms; Cell Proliferation; Endothelial Cells; Glioma; Humans; Isocitra | 2023 |
Oncometabolite D-2-hydroxyglutarate-dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia.
Topics: Animals; Cachexia; Glioma; Humans; Mice; Muscle Fibers, Skeletal; Muscular Atrophy | 2023 |
Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E.
Topics: Animals; Apoptosis; Brain Neoplasms; Carcinogenesis; Endoplasmic Reticulum Stress; Gene Expression R | 2019 |
In vivo 2-hydroxyglutarate-proton magnetic resonance spectroscopy (3 T, PRESS technique) in treatment-naïve suspect lower-grade gliomas: feasibility and accuracy in a clinical setting.
Topics: Biomarkers; Feasibility Studies; Female; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Magne | 2020 |
Novel IDH1-Targeted Glioma Therapies.
Topics: Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Gl | 2019 |
Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1-mutated Human Gliomas.
Topics: Adult; Brain; Brain Neoplasms; Female; Glioma; Glutarates; Humans; Image Interpretation, Computer-As | 2020 |
Whole-Brain MR Spectroscopy Imaging of Brain Tumor Metabolites.
Topics: Brain; Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spe | 2020 |
In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients.
Topics: Animals; Brain Neoplasms; Computer Simulation; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; | 2020 |
Using arterial-venous analysis to characterize cancer metabolic consumption in patients.
Topics: Acetylcarnitine; Adult; Aged; Agmatine; Biomarkers, Tumor; Blood; Blood Chemical Analysis; Blood Glu | 2020 |
MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy | 2020 |
Quantitative analysis of 2-hydroxyglutarate as a controversial oncometabolite in malignant gliomas.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation | 2020 |
Chiral discrimination in a mutated IDH enzymatic reaction in cancer: a computational perspective.
Topics: Brain Neoplasms; Catalytic Domain; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Ketoglutari | 2020 |
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice.
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cellular Reprogramming; Chemoradiotherapy; Ga | 2021 |
Spectral fitting strategy to overcome the overlap between 2-hydroxyglutarate and lipid resonances at 2.25 ppm.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Lipids; Magnetic Resonance Spectroscopy | 2021 |
Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma.
Topics: Animals; Biomarkers, Tumor; Brain; Brain Neoplasms; Disease Models, Animal; Female; Glioma; Glutarat | 2021 |
Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment.
Topics: Animals; CD8-Positive T-Lymphocytes; Chemokine CXCL10; Chemokine CXCL9; Glioma; Glutarates; Humans; | 2017 |
IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Culture Media, Serum-Free; Gene Expression Reg | 2017 |
Isocitrate dehydrogenase mutation as a therapeutic target in gliomas.
Topics: Brain Neoplasms; Cell Line, Tumor; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Ketoglutara | 2017 |
Echo-planar spectroscopic imaging with dual-readout alternated gradients (DRAG-EPSI) at 7 T: Application for 2-hydroxyglutarate imaging in glioma patients.
Topics: Adult; Biomarkers; Brain Neoplasms; Echo-Planar Imaging; Female; Glioma; Glutarates; Humans; Image P | 2018 |
Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant
Topics: Brain Neoplasms; DNA Copy Number Variations; DNA Methylation; Epigenomics; Gene Amplification; Gene | 2017 |
In vivo Metabolic Profiles as Determined by
Topics: Adult; Aged; Analysis of Variance; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Diagnosis, Diffe | 2019 |
Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Astrocytoma; bcl-X Protein; Brain Neop | 2017 |
A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit.
Topics: Adult; Animals; Brain; Brain Neoplasms; Enzyme Inhibitors; Female; Gene Expression Profiling; Glioma | 2017 |
A comparison of 2-hydroxyglutarate detection at 3 and 7 T with long-TE semi-LASER.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Female; Glioma; Glutarates; Humans; Isocitrate Dehydrogen | 2018 |
2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.
Topics: Animals; Autophagy; Biomarkers; Biopsy; Cell Line, Tumor; Endoplasmic Reticulum; Gene Expression Reg | 2018 |
Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry.
Topics: Biomarkers, Tumor; Brain; Brain Chemistry; Brain Neoplasms; Cryopreservation; Glioma; Glutarates; Hu | 2018 |
Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system.
Topics: Central Nervous System; Diffusion; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Models, The | 2018 |
Rapid detection of mutation in isocitrate dehydrogenase 1 and 2 genes using mass spectrometry.
Topics: Biomarkers, Tumor; Central Nervous System Neoplasms; Chromatography, Liquid; Gene Deletion; Glioma; | 2018 |
IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53.
Topics: Animals; Arginine; Brain Neoplasms; Carcinogenesis; Cell Proliferation; Gene Expression Regulation, | 2018 |
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Brain Neoplasms; Calcium; Cell Line, Tumor; Cell Prolife | 2018 |
900MHz 1H-/13C-NMR analysis of 2-hydroxyglutarate and other brain metabolites in human brain tumor tissue extracts.
Topics: Brain; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Chloroform; Deuterium Oxide; Glio | 2018 |
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
Topics: Cell Line, Tumor; Glioma; Glutamic Acid; Glutarates; Homeostasis; Humans; Isocitrate Dehydrogenase; | 2018 |
3D high-resolution imaging of 2-hydroxyglutarate in glioma patients using DRAG-EPSI at 3T in vivo.
Topics: Acoustics; Adult; Algorithms; Astrocytoma; Brain; Brain Mapping; Brain Neoplasms; Contrast Media; Ec | 2019 |
Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry.
Topics: Adult; Brain Neoplasms; Gas Chromatography-Mass Spectrometry; Glioma; Glutarates; Humans; Immunohist | 2019 |
Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations.
Topics: Alcohol Oxidoreductases; Cell Line, Tumor; Chromatography, Liquid; Glioma; Glutarates; HCT116 Cells; | 2019 |
PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival.
Topics: Adaptor Proteins, Signal Transducing; Animals; Astrocytes; Brain Neoplasms; Cell Cycle Proteins; Cel | 2019 |
Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas.
Topics: Adult; Aged; Brain Neoplasms; Chromatography, Liquid; Disease Progression; Female; Glioma; Glutarate | 2013 |
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Topics: Animals; Benzeneacetamides; Cell Differentiation; Cell Transformation, Neoplastic; Enzyme Inhibitors | 2013 |
A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors.
Topics: Adult; Aspartic Acid; Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Glutamic Acid; Glutamine; Gl | 2013 |
Non-invasive in vivo assessment of IDH1 mutational status in glioma.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cell Extracts; Cell Line, Tumor; DNA Mutational Analysis; | 2013 |
Autophagy and oxidative stress in gliomas with IDH1 mutations.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Cel | 2014 |
D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma.
Topics: Brain Neoplasms; Cell Movement; Cell Survival; Glioma; Glutarates; Green Fluorescent Proteins; HEK29 | 2014 |
Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β.
Topics: beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioma; Glutarates; Glycogen Synt | 2014 |
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioma; Glutaminase; Glutamine; Glutarates; HEK293 C | 2014 |
Accuracy of 2-hydroxyglutarate quantification by short-echo proton-MRS at 3 T: a phantom study.
Topics: Aspartic Acid; Brain; Glioma; Glutamic Acid; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation; | 2014 |
Intraoperative mass spectrometry of tumor metabolites.
Topics: Brain Neoplasms; Female; Glioma; Glutarates; Humans; Intraoperative Care; Magnetic Resonance Imaging | 2014 |
Metabolomic comparison between cells over-expressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism.
Topics: Benzeneacetamides; Cell Line; Chromatography, Liquid; Citric Acid Cycle; Glioma; Glutarates; Humans; | 2015 |
Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Crystallography, X-Ray; Drug S | 2014 |
Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy.
Topics: Adult; Aged; Brain; Brain Neoplasms; Female; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; K | 2014 |
D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Etoposide; Gene Expression Regulation, Neoplastic; | 2015 |
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Down-Regulati | 2015 |
Diagnostic value of plasma and urinary 2-hydroxyglutarate to identify patients with isocitrate dehydrogenase-mutated glioma.
Topics: Adult; Aged; Biomarkers, Tumor; Female; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Middle | 2015 |
Conditions for (13)C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas.
Topics: Carbon Isotopes; Glioma; Glutamic Acid; Glutamine; Glutarates; Humans; Isocitrate Dehydrogenase; Mag | 2015 |
Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate.
Topics: Biomarkers; Brain; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Female; Glioma; Glutarates; Humans; | 2016 |
Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.
Topics: Adult; Brain Neoplasms; Case-Control Studies; Female; Glioma; Glutarates; Humans; Isocitrate Dehydro | 2016 |
Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.
Topics: Adult; Aged; Brain Neoplasms; Female; Follow-Up Studies; Glioma; Glutarates; Humans; Isocitrate Dehy | 2016 |
Insulator dysfunction and oncogene activation in IDH mutant gliomas.
Topics: Base Sequence; Binding Sites; CCCTC-Binding Factor; Cell Cycle Proteins; Cell Proliferation; Cell Tr | 2016 |
On the Utility of Short Echo Time (TE) Single Voxel 1H-MRS in Non-Invasive Detection of 2-Hydroxyglutarate (2HG); Challenges and Potential Improvement Illustrated with Animal Models Using MRUI and LCModel.
Topics: Animals; Biomarkers, Tumor; Brain; Brain Neoplasms; Cell Line, Tumor; Chromatography, Liquid; Female | 2016 |
Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma.
Topics: Adult; Aged; Biomarkers, Tumor; Female; Genotype; Glioma; Glutarates; Humans; Isocitrate Dehydrogena | 2016 |
MR spectroscopy for in vivo assessment of the oncometabolite 2-hydroxyglutarate and its effects on cellular metabolism in human brain gliomas at 9.4T.
Topics: Alcohol Oxidoreductases; Algorithms; Biomarkers, Tumor; Brain Neoplasms; Glioma; Glutarates; Humans; | 2016 |
Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Brain Neoplasms; Glioma; Glutamate Dehydroge | 2016 |
Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase.
Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Neoplasms; Cerebrospinal Fluid; Female; Glioma; Glutara | 2016 |
Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients.
Topics: Adult; Aged, 80 and over; Brain; Brain Neoplasms; Female; Glioma; Glutarates; Humans; Isocitrate Deh | 2016 |
Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
Topics: Aldehyde Dehydrogenase; Alleles; Cell Line, Tumor; DNA, Mitochondrial; Glioma; Glutarates; Humans; I | 2016 |
Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis.
Topics: Astrocytes; Benzeneacetamides; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2016 |
Urine 2-Hydroxyglutarate in Glioma.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation | 2016 |
The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
Topics: Astrocytes; beta-Transducin Repeat-Containing Proteins; Citric Acid Cycle; Glioma; Glutarates; HEK29 | 2016 |
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Topics: Animals; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Repair; Female; Glioma; Glutarates; Homo | 2017 |
Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain Chemistry; Brain Neoplasms; Female; Glioma; Glutarates; H | 2016 |
Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; DNA Mutational Analysis; Female; Glioma; Glutarates; Human | 2018 |
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Topics: Arginine; Brain Neoplasms; Catalytic Domain; Cell Line; Crystallography, X-Ray; Disease Progression; | 2009 |
IDH1 and IDH2 mutations in gliomas and the associated induction of hypoxia-inducible factor and production of 2-hydroxyglutarate.
Topics: Gene Expression Regulation, Neoplastic; Glioma; Glutarates; Humans; Hypoxia-Inducible Factor 1, alph | 2010 |
Metabolism, gliomas, and IDH1.
Topics: Brain Neoplasms; Genetic Markers; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Isocitrates; | 2010 |
Metabolic syndromes and malignant transformation: where the twain shall meet.
Topics: Cell Transformation, Neoplastic; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Leukemia, Mye | 2010 |
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
Topics: Blotting, Western; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Dose-Response Relat | 2010 |
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Topics: 5-Methylcytosine; Amino Acid Substitution; Animals; Binding, Competitive; Biocatalysis; Caenorhabdit | 2011 |
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.
Topics: Cell Line, Tumor; Dipeptides; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Metabolome; Muta | 2011 |
2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.
Topics: Binding, Competitive; Brain Neoplasms; Cells, Cultured; Down-Regulation; Enzyme Activation; Genes, D | 2011 |
Detection of 2-hydroxyglutarate in formalin-fixed paraffin-embedded glioma specimens by gas chromatography/mass spectrometry.
Topics: Brain Neoplasms; Fixatives; Formaldehyde; Gas Chromatography-Mass Spectrometry; Glioma; Glutarates; | 2012 |
Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift?
Topics: Brain Neoplasms; Evolution, Molecular; Glioma; Glutarates; Glycolysis; Humans; Isocitrate Dehydrogen | 2011 |
2-Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size.
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Female; Glioma; Glutarates; Humans; Isocitrate Dehy | 2012 |
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; Chromatography, Liquid; DNA, Neo | 2012 |
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy.
Topics: Adult; Aged; Biopsy; Brain Neoplasms; Epilepsy; Female; Glioma; Glutarates; Humans; Isocitrate Dehyd | 2012 |
Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas.
Topics: Amino Acid Sequence; Base Sequence; Brain Neoplasms; DNA Mutational Analysis; Glioma; Glutarates; Hu | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
Topics: Astrocytes; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Dioxyg | 2012 |
IDH mutation impairs histone demethylation and results in a block to cell differentiation.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Astrocytes; Cell Differentiation; Cell Line, Tumor; Cell Lineage; | 2012 |
Detection of "oncometabolite" 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma.
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Child; Child, Preschool; DNA Mutational Analysis; F | 2012 |
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
Topics: Animals; Basement Membrane; Brain; Collagen; Gene Knock-In Techniques; Genotype; Glioma; Glutarates; | 2012 |
Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Glioma; Glutarates; Humans; Immunohistochemistry; | 2012 |
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Topics: Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Genotype; Glioblastoma; Glioma; Glutarates; Humans; | 2013 |