alpha-hydroxyglutarate has been researched along with Glioblastoma in 16 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous ex vivo spectroscopic data from tissue samples revealed differences in phospholipid metabolites between isocitrate dehydrogenase mutated (IDHmut) and IDH wildtype (IDHwt) gliomas." | 3.91 | In vivo Metabolic Profiles as Determined by ( Bähr, O; Franz, K; Hattingen, E; Pilatus, U; Steinbach, J; Wenger, KJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 12 (75.00) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Walsby-Tickle, J | 1 |
| Gannon, J | 1 |
| Hvinden, I | 1 |
| Bardella, C | 1 |
| Abboud, MI | 1 |
| Nazeer, A | 1 |
| Hauton, D | 1 |
| Pires, E | 1 |
| Cadoux-Hudson, T | 1 |
| Schofield, CJ | 1 |
| McCullagh, JSO | 1 |
| Barekatain, Y | 1 |
| Yan, VC | 1 |
| Arthur, K | 1 |
| Ackroyd, JJ | 1 |
| Khadka, S | 1 |
| De Groot, J | 1 |
| Huse, JT | 1 |
| Muller, FL | 1 |
| Bhandari, A | 1 |
| Sharma, C | 1 |
| Ibrahim, M | 1 |
| Riggs, M | 1 |
| Jones, R | 1 |
| Lasocki, A | 1 |
| Natsumeda, M | 1 |
| Motohashi, K | 1 |
| Igarashi, H | 1 |
| Nozawa, T | 1 |
| Abe, H | 1 |
| Tsukamoto, Y | 1 |
| Ogura, R | 1 |
| Okada, M | 1 |
| Kobayashi, T | 1 |
| Aoki, H | 1 |
| Takahashi, H | 1 |
| Kakita, A | 1 |
| Okamoto, K | 1 |
| Nakada, T | 1 |
| Fujii, Y | 1 |
| Wenger, KJ | 1 |
| Hattingen, E | 1 |
| Franz, K | 1 |
| Steinbach, J | 1 |
| Bähr, O | 1 |
| Pilatus, U | 1 |
| Karpel-Massler, G | 1 |
| Ishida, CT | 1 |
| Bianchetti, E | 1 |
| Zhang, Y | 2 |
| Shu, C | 1 |
| Tsujiuchi, T | 1 |
| Banu, MA | 1 |
| Garcia, F | 1 |
| Roth, KA | 1 |
| Bruce, JN | 1 |
| Canoll, P | 1 |
| Siegelin, MD | 1 |
| Miyata, S | 1 |
| Tominaga, K | 1 |
| Sakashita, E | 1 |
| Urabe, M | 1 |
| Onuki, Y | 1 |
| Gomi, A | 1 |
| Yamaguchi, T | 1 |
| Mieno, M | 1 |
| Mizukami, H | 1 |
| Kume, A | 1 |
| Ozawa, K | 1 |
| Watanabe, E | 1 |
| Kawai, K | 1 |
| Endo, H | 1 |
| Izquierdo-Garcia, JL | 1 |
| Viswanath, P | 1 |
| Eriksson, P | 1 |
| Cai, L | 1 |
| Radoul, M | 1 |
| Chaumeil, MM | 1 |
| Blough, M | 1 |
| Luchman, HA | 1 |
| Weiss, S | 1 |
| Cairncross, JG | 1 |
| Phillips, JJ | 1 |
| Pieper, RO | 1 |
| Ronen, SM | 1 |
| Waitkus, MS | 1 |
| Diplas, BH | 1 |
| Yan, H | 3 |
| Fu, X | 1 |
| Chin, RM | 1 |
| Vergnes, L | 1 |
| Hwang, H | 1 |
| Deng, G | 2 |
| Xing, Y | 1 |
| Pai, MY | 1 |
| Li, S | 1 |
| Ta, L | 1 |
| Fazlollahi, F | 1 |
| Chen, C | 1 |
| Prins, RM | 1 |
| Teitell, MA | 1 |
| Nathanson, DA | 1 |
| Lai, A | 1 |
| Faull, KF | 1 |
| Jiang, M | 1 |
| Clarke, SG | 1 |
| Cloughesy, TF | 1 |
| Graeber, TG | 1 |
| Braas, D | 1 |
| Christofk, HR | 1 |
| Jung, ME | 1 |
| Reue, K | 1 |
| Huang, J | 1 |
| Tateishi, K | 1 |
| Wakimoto, H | 1 |
| Iafrate, AJ | 1 |
| Tanaka, S | 1 |
| Loebel, F | 1 |
| Lelic, N | 1 |
| Wiederschain, D | 1 |
| Bedel, O | 1 |
| Zhang, B | 1 |
| He, T | 1 |
| Shi, X | 1 |
| Gerszten, RE | 1 |
| Yeh, JJ | 1 |
| Curry, WT | 1 |
| Zhao, D | 1 |
| Sundaram, S | 1 |
| Nigim, F | 1 |
| Koerner, MVA | 1 |
| Ho, Q | 1 |
| Fisher, DE | 1 |
| Roider, EM | 1 |
| Kemeny, LV | 1 |
| Samuels, Y | 1 |
| Flaherty, KT | 1 |
| Batchelor, TT | 1 |
| Chi, AS | 1 |
| Cahill, DP | 1 |
| Giampà, M | 1 |
| Lissel, MB | 1 |
| Patschkowski, T | 1 |
| Fuchser, J | 1 |
| Hans, VH | 1 |
| Gembruch, O | 1 |
| Bednarz, H | 1 |
| Niehaus, K | 1 |
| Reitman, ZJ | 2 |
| Garber, K | 1 |
| Jin, G | 1 |
| Duncan, CG | 1 |
| Spasojevic, I | 1 |
| Gooden, DM | 1 |
| Rasheed, BA | 1 |
| Yang, R | 1 |
| Lopez, GY | 1 |
| He, Y | 1 |
| McLendon, RE | 1 |
| Bigner, DD | 1 |
| Moroni, I | 1 |
| Bugiani, M | 1 |
| D'Incerti, L | 1 |
| Maccagnano, C | 1 |
| Rimoldi, M | 1 |
| Bissola, L | 1 |
| Pollo, B | 1 |
| Finocchiaro, G | 1 |
| Uziel, G | 1 |
4 reviews available for alpha-hydroxyglutarate and Glioblastoma
| Article | Year |
|---|---|
The role of 2-hydroxyglutarate magnetic resonance spectroscopy for the determination of isocitrate dehydrogenase status in lower grade gliomas versus glioblastoma: a systematic review and meta-analysis of diagnostic test accuracy.
Topics: Brain Neoplasms; Diagnostic Tests, Routine; Glioblastoma; Glioma; Glutarates; Humans; Isocitrate Deh | 2021 |
Isocitrate dehydrogenase mutations in gliomas.
Topics: Animals; Brain Neoplasms; Glioblastoma; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Ketogl | 2016 |
Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.
Topics: Animals; Arginine; Brain Neoplasms; Codon; Gene Expression Regulation, Enzymologic; Gene Expression | 2010 |
L-2-hydroxyglutaric aciduria and brain malignant tumors: a predisposing condition?
Topics: Adolescent; Adult; Astrocytoma; Brain Diseases, Metabolic; Brain Neoplasms; Cerebellar Ataxia; Child | 2004 |
12 other studies available for alpha-hydroxyglutarate and Glioblastoma
| Article | Year |
|---|---|
Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells.
Topics: Cell Line, Tumor; Chromatography, Ion Exchange; Glioblastoma; Glutarates; Humans; Isocitrate Dehydro | 2020 |
Robust detection of oncometabolic aberrations by
Topics: Animals; Biomarkers, Tumor; Carbon Isotopes; Cell Line, Tumor; Female; Glioblastoma; Gluconates; Glu | 2020 |
Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Child; Female; Glioblastoma; Glutarates | 2018 |
In vivo Metabolic Profiles as Determined by
Topics: Adult; Aged; Analysis of Variance; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Diagnosis, Diffe | 2019 |
Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Astrocytoma; bcl-X Protein; Brain Neop | 2017 |
Comprehensive Metabolomic Analysis of IDH1
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Carnitine; Cell Division; Cell Line, Tumor; Female; | 2019 |
IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.
Topics: Astrocytes; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Down-Regulation; Glioblastoma | 2015 |
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
Topics: Adenosine Triphosphatases; Animals; Caenorhabditis elegans; Cell Proliferation; Glioblastoma; Glutar | 2015 |
Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Autophagy; Brain Neoplasms; Cell Prol | 2015 |
Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry.
Topics: Brain; Brain Neoplasms; Chlorides; Glioblastoma; Glutarates; Humans; Lactic Acid; Maleic Anhydrides; | 2016 |
Oncometabolite? IDH1 discoveries raise possibility of new metabolism targets in brain cancers and leukemia.
Topics: Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppre | 2010 |
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Topics: Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Genotype; Glioblastoma; Glioma; Glutarates; Humans; | 2013 |