alpha-hydroxyglutarate has been researched along with Fibrosarcoma in 3 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zaprinast treatment reversed histone hypermethylation and soft-agar growth of IDH1-mutant cells, and treatment of glutamine-addicted pancreatic cancer cells reduced growth and sensitized cells to oxidative damage." | 1.40 | A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. ( Collins, L; Crowley, J; Elhammali, A; Ippolito, JE; Marasa, J; Piwnica-Worms, D, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hujber, Z | 1 |
| Petővári, G | 1 |
| Szoboszlai, N | 1 |
| Dankó, T | 1 |
| Nagy, N | 1 |
| Kriston, C | 1 |
| Krencz, I | 1 |
| Paku, S | 1 |
| Ozohanics, O | 1 |
| Drahos, L | 1 |
| Jeney, A | 1 |
| Sebestyén, A | 1 |
| Badur, MG | 1 |
| Muthusamy, T | 1 |
| Parker, SJ | 1 |
| Ma, S | 1 |
| McBrayer, SK | 1 |
| Cordes, T | 1 |
| Magana, JH | 1 |
| Guan, KL | 1 |
| Metallo, CM | 1 |
| Elhammali, A | 1 |
| Ippolito, JE | 1 |
| Collins, L | 1 |
| Crowley, J | 1 |
| Marasa, J | 1 |
| Piwnica-Worms, D | 1 |
3 other studies available for alpha-hydroxyglutarate and Fibrosarcoma
| Article | Year |
|---|---|
Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Movement; Cell Proliferation; Fibrosarcoma; Gl | 2017 |
Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.
Topics: Cell Line, Tumor; Cytosol; Fibrosarcoma; Glutarates; Humans; Isocitrate Dehydrogenase; Lipids; Lipog | 2018 |
A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.
Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Fibrosarcoma; Glutaminase; Glutarates; HEK293 Cells; H | 2014 |