alpha-hydroxyglutarate and Fibrosarcoma
alpha-hydroxyglutarate has been researched along with Fibrosarcoma in 3 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zaprinast treatment reversed histone hypermethylation and soft-agar growth of IDH1-mutant cells, and treatment of glutamine-addicted pancreatic cancer cells reduced growth and sensitized cells to oxidative damage." | 1.40 | A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. ( Collins, L; Crowley, J; Elhammali, A; Ippolito, JE; Marasa, J; Piwnica-Worms, D, 2014) |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hujber, Z | 1 |
| Petővári, G | 1 |
| Szoboszlai, N | 1 |
| Dankó, T | 1 |
| Nagy, N | 1 |
| Kriston, C | 1 |
| Krencz, I | 1 |
| Paku, S | 1 |
| Ozohanics, O | 1 |
| Drahos, L | 1 |
| Jeney, A | 1 |
| Sebestyén, A | 1 |
| Badur, MG | 1 |
| Muthusamy, T | 1 |
| Parker, SJ | 1 |
| Ma, S | 1 |
| McBrayer, SK | 1 |
| Cordes, T | 1 |
| Magana, JH | 1 |
| Guan, KL | 1 |
| Metallo, CM | 1 |
| Elhammali, A | 1 |
| Ippolito, JE | 1 |
| Collins, L | 1 |
| Crowley, J | 1 |
| Marasa, J | 1 |
| Piwnica-Worms, D | 1 |
Other Studies
3 other studies available for alpha-hydroxyglutarate and Fibrosarcoma
| Article | Year |
|---|---|
Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Movement; Cell Proliferation; Fibrosarcoma; Gl | 2017 |
Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.
Topics: Cell Line, Tumor; Cytosol; Fibrosarcoma; Glutarates; Humans; Isocitrate Dehydrogenase; Lipids; Lipog | 2018 |
A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.
Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Fibrosarcoma; Glutaminase; Glutarates; HEK293 Cells; H | 2014 |