alpha-hydroxyglutarate and Epilepsy
alpha-hydroxyglutarate has been researched along with Epilepsy in 11 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"The older sister presented with severe mental retardation, recurrent epileptic seizures, and progressive deterioration in her ability to walk and to talk; she is now confined to a wheelchair with severe speech deficit." | 1.33 | L-2-Hydroxyglutaric aciduria: clinical, genetic, and brain MRI characteristics in two adult sisters. ( Duprez, TP; Goffette, SM; Jakobs, C; Nassogne, MC; Sindic, CJ; Vincent, MF, 2006) |
Research
Studies (11)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (18.18) | 18.2507 |
2000's | 6 (54.55) | 29.6817 |
2010's | 2 (18.18) | 24.3611 |
2020's | 1 (9.09) | 2.80 |
Authors
Authors | Studies |
---|---|
Winkler, F | 1 |
Saidha, S | 1 |
Murphy, S | 1 |
McCarthy, P | 1 |
Mayne, PD | 1 |
Hennessy, M | 1 |
Andronesi, OC | 1 |
Kim, GS | 1 |
Gerstner, E | 1 |
Batchelor, T | 1 |
Tzika, AA | 1 |
Fantin, VR | 1 |
Vander Heiden, MG | 1 |
Sorensen, AG | 1 |
Clarke, NF | 1 |
Andrews, I | 1 |
Carpenter, K | 1 |
Jakobs, C | 5 |
van der Knaap, MS | 3 |
Kirk, EP | 1 |
Moroni, I | 1 |
Bugiani, M | 1 |
D'Incerti, L | 1 |
Maccagnano, C | 1 |
Rimoldi, M | 1 |
Bissola, L | 1 |
Pollo, B | 1 |
Finocchiaro, G | 1 |
Uziel, G | 1 |
Seijo-Martínez, M | 1 |
Navarro, C | 1 |
Castro del Río, M | 1 |
Vila, O | 1 |
Puig, M | 1 |
Ribes, A | 1 |
Butron, M | 1 |
Goffette, SM | 1 |
Duprez, TP | 1 |
Nassogne, MC | 1 |
Vincent, MF | 1 |
Sindic, CJ | 1 |
Lee, C | 1 |
Born, M | 1 |
Salomons, GS | 1 |
Woelfle, J | 1 |
Geerts, Y | 1 |
Renier, WO | 2 |
Bakkeren, J | 1 |
de Jong, J | 1 |
Hoffmann, GF | 2 |
Nyhan, WL | 1 |
Smeitink, JA | 1 |
Catsman-Berrevoets, CE | 1 |
Hjalmarson, O | 1 |
Vallance, H | 1 |
Sugita, K | 1 |
Bowe, CM | 1 |
Herrin, JT | 1 |
Craigen, WJ | 1 |
Buist, NR | 1 |
Brookfield, DS | 1 |
Chalmers, RA | 1 |
Muntau, AC | 1 |
Röschinger, W | 1 |
Merkenschlager, A | 1 |
Duran, M | 1 |
Roscher, AA | 1 |
Reviews
2 reviews available for alpha-hydroxyglutarate and Epilepsy
Article | Year |
---|---|
L-2-hydroxyglutaric aciduria and brain malignant tumors: a predisposing condition?
Topics: Adolescent; Adult; Astrocytoma; Brain Diseases, Metabolic; Brain Neoplasms; Cerebellar Ataxia; Child | 2004 |
2-Hydroxyglutaric aciduria: a case report on an infant with the D-isomeric form with review of the literature.
Topics: Epilepsy; Glutarates; Humans; Infant; Isomerism; Male; Psychomotor Disorders; Renal Aminoacidurias | 1996 |
Other Studies
9 other studies available for alpha-hydroxyglutarate and Epilepsy
Article | Year |
---|---|
Understanding epilepsy in IDH-mutated gliomas: towards a targeted therapy.
Topics: Epilepsy; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; TOR Serine-Threonine Kinases | 2022 |
L-2-hydroxyglutaric aciduria diagnosed in an adult presenting with acute deterioration.
Topics: Adult; Ataxia; Brain; Disease Progression; Epilepsy; Glutarates; Humans; Lysine; Male; Metabolism, I | 2010 |
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy.
Topics: Adult; Aged; Biopsy; Brain Neoplasms; Epilepsy; Female; Glioma; Glutarates; Humans; Isocitrate Dehyd | 2012 |
D-2-hydroxyglutaric aciduria: a case with an intermediate phenotype and prenatal diagnosis of two affected fetuses.
Topics: Adult; Amniotic Fluid; Craniofacial Abnormalities; Developmental Disabilities; Epilepsy; Female; Glu | 2003 |
L-2-hydroxyglutaric aciduria: clinical, neuroimaging, and neuropathological findings.
Topics: Adolescent; Atrophy; Brain; Brain Diseases, Metabolic, Inborn; Epilepsy; Fatal Outcome; Folic Acid; | 2005 |
L-2-Hydroxyglutaric aciduria: clinical, genetic, and brain MRI characteristics in two adult sisters.
Topics: Adult; Age of Onset; Brain; Electromyography; Epilepsy; Female; Glutarates; Humans; Intellectual Dis | 2006 |
Hemiconvulsion-hemiplegia-epilepsy syndrome as a presenting feature of L-2-hydroxyglutaric aciduria.
Topics: Epilepsy; Female; Glutarates; Hemiplegia; Humans; Infant; Metabolism, Inborn Errors; Syndrome | 2006 |
D-2-Hydroxyglutaric aciduria: biochemical marker or clinical disease entity?
Topics: Biomarkers; Cerebral Ventricles; Child, Preschool; Chorea; Cysts; Ependyma; Epilepsy; Family Health; | 1999 |
Combined D-2- and L-2-hydroxyglutaric aciduria with neonatal onset encephalopathy: a third biochemical variant of 2-hydroxyglutaric aciduria?
Topics: Biomarkers; Brain; Brain Diseases, Metabolic, Inborn; Chromatography, Gas; Diagnosis, Differential; | 2000 |