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alpha-hydroxyglutarate and Epilepsy

alpha-hydroxyglutarate has been researched along with Epilepsy in 11 studies

2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"The older sister presented with severe mental retardation, recurrent epileptic seizures, and progressive deterioration in her ability to walk and to talk; she is now confined to a wheelchair with severe speech deficit."1.33L-2-Hydroxyglutaric aciduria: clinical, genetic, and brain MRI characteristics in two adult sisters. ( Duprez, TP; Goffette, SM; Jakobs, C; Nassogne, MC; Sindic, CJ; Vincent, MF, 2006)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's6 (54.55)29.6817
2010's2 (18.18)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Winkler, F1
Saidha, S1
Murphy, S1
McCarthy, P1
Mayne, PD1
Hennessy, M1
Andronesi, OC1
Kim, GS1
Gerstner, E1
Batchelor, T1
Tzika, AA1
Fantin, VR1
Vander Heiden, MG1
Sorensen, AG1
Clarke, NF1
Andrews, I1
Carpenter, K1
Jakobs, C5
van der Knaap, MS3
Kirk, EP1
Moroni, I1
Bugiani, M1
D'Incerti, L1
Maccagnano, C1
Rimoldi, M1
Bissola, L1
Pollo, B1
Finocchiaro, G1
Uziel, G1
Seijo-Martínez, M1
Navarro, C1
Castro del Río, M1
Vila, O1
Puig, M1
Ribes, A1
Butron, M1
Goffette, SM1
Duprez, TP1
Nassogne, MC1
Vincent, MF1
Sindic, CJ1
Lee, C1
Born, M1
Salomons, GS1
Woelfle, J1
Geerts, Y1
Renier, WO2
Bakkeren, J1
de Jong, J1
Hoffmann, GF2
Nyhan, WL1
Smeitink, JA1
Catsman-Berrevoets, CE1
Hjalmarson, O1
Vallance, H1
Sugita, K1
Bowe, CM1
Herrin, JT1
Craigen, WJ1
Buist, NR1
Brookfield, DS1
Chalmers, RA1
Muntau, AC1
Röschinger, W1
Merkenschlager, A1
Duran, M1
Roscher, AA1

Reviews

2 reviews available for alpha-hydroxyglutarate and Epilepsy

ArticleYear
L-2-hydroxyglutaric aciduria and brain malignant tumors: a predisposing condition?
    Neurology, 2004, May-25, Volume: 62, Issue:10

    Topics: Adolescent; Adult; Astrocytoma; Brain Diseases, Metabolic; Brain Neoplasms; Cerebellar Ataxia; Child

2004
2-Hydroxyglutaric aciduria: a case report on an infant with the D-isomeric form with review of the literature.
    Journal of the neurological sciences, 1996, Volume: 143, Issue:1-2

    Topics: Epilepsy; Glutarates; Humans; Infant; Isomerism; Male; Psychomotor Disorders; Renal Aminoacidurias

1996

Other Studies

9 other studies available for alpha-hydroxyglutarate and Epilepsy

ArticleYear
Understanding epilepsy in IDH-mutated gliomas: towards a targeted therapy.
    Neuro-oncology, 2022, 09-01, Volume: 24, Issue:9

    Topics: Epilepsy; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; TOR Serine-Threonine Kinases

2022
L-2-hydroxyglutaric aciduria diagnosed in an adult presenting with acute deterioration.
    Journal of neurology, 2010, Volume: 257, Issue:1

    Topics: Adult; Ataxia; Brain; Disease Progression; Epilepsy; Glutarates; Humans; Lysine; Male; Metabolism, I

2010
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy.
    Science translational medicine, 2012, Jan-11, Volume: 4, Issue:116

    Topics: Adult; Aged; Biopsy; Brain Neoplasms; Epilepsy; Female; Glioma; Glutarates; Humans; Isocitrate Dehyd

2012
D-2-hydroxyglutaric aciduria: a case with an intermediate phenotype and prenatal diagnosis of two affected fetuses.
    American journal of medical genetics. Part A, 2003, Aug-01, Volume: 120A, Issue:4

    Topics: Adult; Amniotic Fluid; Craniofacial Abnormalities; Developmental Disabilities; Epilepsy; Female; Glu

2003
L-2-hydroxyglutaric aciduria: clinical, neuroimaging, and neuropathological findings.
    Archives of neurology, 2005, Volume: 62, Issue:4

    Topics: Adolescent; Atrophy; Brain; Brain Diseases, Metabolic, Inborn; Epilepsy; Fatal Outcome; Folic Acid;

2005
L-2-Hydroxyglutaric aciduria: clinical, genetic, and brain MRI characteristics in two adult sisters.
    European journal of neurology, 2006, Volume: 13, Issue:5

    Topics: Adult; Age of Onset; Brain; Electromyography; Epilepsy; Female; Glutarates; Humans; Intellectual Dis

2006
Hemiconvulsion-hemiplegia-epilepsy syndrome as a presenting feature of L-2-hydroxyglutaric aciduria.
    Journal of child neurology, 2006, Volume: 21, Issue:6

    Topics: Epilepsy; Female; Glutarates; Hemiplegia; Humans; Infant; Metabolism, Inborn Errors; Syndrome

2006
D-2-Hydroxyglutaric aciduria: biochemical marker or clinical disease entity?
    Annals of neurology, 1999, Volume: 45, Issue:1

    Topics: Biomarkers; Cerebral Ventricles; Child, Preschool; Chorea; Cysts; Ependyma; Epilepsy; Family Health;

1999
Combined D-2- and L-2-hydroxyglutaric aciduria with neonatal onset encephalopathy: a third biochemical variant of 2-hydroxyglutaric aciduria?
    Neuropediatrics, 2000, Volume: 31, Issue:3

    Topics: Biomarkers; Brain; Brain Diseases, Metabolic, Inborn; Chromatography, Gas; Diagnosis, Differential;

2000
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