alpha-hydroxyglutarate has been researched along with Disease Models, Animal in 14 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There were also increases in plasma 2HG in CER-treated rats on Days 8 and 11 and in TMPD-treated rats at 24 hr after dosing and increases in plasma hexanoylcarnitine in CER-treated rats on Day 11 and in TMPD-treated rats at 6 and 24 hr after dosing." | 1.46 | Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. ( Asai, F; Kobayashi, N; Nezu, Y; Obayashi, H; Shirai, M; Yamoto, T, 2017) |
| "Since polycystic kidney disease (PKD) was first noted over 30 years ago to have neoplastic parallels, there has been a resurgent interest in elucidating neoplasia-relevant pathways in PKD." | 1.42 | The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. ( Bell, PD; Guay-Woodford, LM; Hammock, B; Hwang, VJ; Kim, J; Rand, A; Sturdivant, S; Weiss, RH; Yang, C, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Tharakan, A | 1 |
| Kumar, A | 1 |
| Allegood, J | 1 |
| Cowart, LA | 1 |
| Conrad, DH | 1 |
| Martin, RK | 1 |
| Lan, C | 1 |
| Li, H | 1 |
| Wang, L | 1 |
| Zhang, J | 1 |
| Wang, X | 1 |
| Zhang, R | 1 |
| Yuan, X | 1 |
| Wu, T | 1 |
| Wu, J | 1 |
| Lu, M | 1 |
| Ma, X | 1 |
| Obayashi, H | 2 |
| Kobayashi, N | 2 |
| Nezu, Y | 2 |
| Yamoto, T | 2 |
| Shirai, M | 2 |
| Asai, F | 2 |
| Shelar, S | 1 |
| Shim, EH | 1 |
| Brinkley, GJ | 1 |
| Kundu, A | 1 |
| Carobbio, F | 1 |
| Poston, T | 1 |
| Tan, J | 1 |
| Parekh, V | 1 |
| Benson, D | 1 |
| Crossman, DK | 1 |
| Buckhaults, PJ | 1 |
| Rakheja, D | 1 |
| Kirkman, R | 1 |
| Sato, Y | 1 |
| Ogawa, S | 1 |
| Dutta, S | 1 |
| Velu, SE | 1 |
| Emberley, E | 1 |
| Pan, A | 1 |
| Chen, J | 1 |
| Huang, T | 1 |
| Absher, D | 1 |
| Becker, A | 1 |
| Kunick, C | 1 |
| Sudarshan, S | 1 |
| Saha, SK | 1 |
| Parachoniak, CA | 1 |
| Ghanta, KS | 1 |
| Fitamant, J | 1 |
| Ross, KN | 1 |
| Najem, MS | 1 |
| Gurumurthy, S | 1 |
| Akbay, EA | 1 |
| Sia, D | 1 |
| Cornella, H | 1 |
| Miltiadous, O | 1 |
| Walesky, C | 1 |
| Deshpande, V | 1 |
| Zhu, AX | 1 |
| Hezel, AF | 1 |
| Yen, KE | 1 |
| Straley, KS | 1 |
| Travins, J | 1 |
| Popovici-Muller, J | 1 |
| Gliser, C | 1 |
| Ferrone, CR | 1 |
| Apte, U | 1 |
| Llovet, JM | 1 |
| Wong, KK | 1 |
| Ramaswamy, S | 1 |
| Bardeesy, N | 1 |
| Reitman, ZJ | 1 |
| Sinenko, SA | 1 |
| Spana, EP | 1 |
| Yan, H | 1 |
| Rzem, R | 1 |
| Achouri, Y | 1 |
| Marbaix, E | 1 |
| Schakman, O | 1 |
| Wiame, E | 1 |
| Marie, S | 1 |
| Gailly, P | 1 |
| Vincent, MF | 1 |
| Veiga-da-Cunha, M | 1 |
| Van Schaftingen, E | 1 |
| Pellegatta, S | 1 |
| Valletta, L | 1 |
| Corbetta, C | 1 |
| Patanè, M | 1 |
| Zucca, I | 1 |
| Riccardi Sirtori, F | 1 |
| Bruzzone, MG | 1 |
| Fogliatto, G | 1 |
| Isacchi, A | 1 |
| Pollo, B | 1 |
| Finocchiaro, G | 1 |
| Hwang, VJ | 1 |
| Kim, J | 1 |
| Rand, A | 1 |
| Yang, C | 1 |
| Sturdivant, S | 1 |
| Hammock, B | 1 |
| Bell, PD | 1 |
| Guay-Woodford, LM | 1 |
| Weiss, RH | 1 |
| Lazovic, J | 1 |
| Soto, H | 1 |
| Piccioni, D | 1 |
| Lou, JR | 1 |
| Li, S | 1 |
| Mirsadraei, L | 1 |
| Yong, W | 1 |
| Prins, R | 1 |
| Liau, LM | 1 |
| Ellingson, BM | 1 |
| Cloughesy, TF | 1 |
| Lai, A | 1 |
| Pope, WB | 1 |
| Das, AM | 1 |
| Junqueira, D | 1 |
| Brusque, AM | 1 |
| Porciúncula, LO | 1 |
| Rotta, LN | 1 |
| Frizzo, ME | 1 |
| Wyse, AT | 1 |
| Wannmacher, CM | 1 |
| Souza, DO | 1 |
| Wajner, M | 1 |
| Penderis, J | 1 |
| Calvin, J | 1 |
| Abramson, C | 1 |
| Jakobs, C | 1 |
| Pettitt, L | 1 |
| Binns, MM | 1 |
| Verhoeven, NM | 1 |
| O'Driscoll, E | 1 |
| Platt, SR | 1 |
| Mellersh, CS | 1 |
1 review available for alpha-hydroxyglutarate and Disease Models, Animal
| Article | Year |
|---|---|
Regulation of the mitochondrial ATP-synthase in health and disease.
Topics: Animals; Brain; Brain Diseases, Metabolic, Inborn; Cells, Cultured; Chickens; Disease; Disease Model | 2003 |
13 other studies available for alpha-hydroxyglutarate and Disease Models, Animal
| Article | Year |
|---|---|
D-2-hydroxyglutarate suppresses allergic sensitization in a murine model of experimental asthma.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Glutarates; Humans; Mice | 2023 |
Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma.
Topics: Animals; Biomarkers, Tumor; Brain; Brain Neoplasms; Disease Models, Animal; Female; Glioma; Glutarat | 2021 |
Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats.
Topics: Aniline Compounds; Animals; Biomarkers; Carnitine; Creatine Kinase; Disease Models, Animal; Glutarat | 2017 |
Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.
Topics: Alcohol Oxidoreductases; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Disease Mo | 2018 |
Plasma 2-hydroxyglutarate, a promising prognostic biomarker candidate for skeletal muscle injury in Fischer 344 rats.
Topics: Aniline Compounds; Animals; Biomarkers; Disease Models, Animal; Glutarates; Male; Muscle, Skeletal; | 2018 |
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Differentiation; Cell Division; Cell Li | 2014 |
Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Glutarates; | 2015 |
A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair.
Topics: Alcohol Oxidoreductases; Animals; Arginine; Brain; Brain Diseases, Metabolic, Inborn; Cells, Culture | 2015 |
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Down-Regulati | 2015 |
The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate.
Topics: Animals; Cells, Cultured; Creatine Kinase; Disease Models, Animal; DNA Mutational Analysis; Enzyme I | 2015 |
Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Glioma; Glutarates; Humans; Immunohistochemistry; | 2012 |
In vitro effects of D-2-hydroxyglutaric acid on glutamate binding, uptake and release in cerebral cortex of rats.
Topics: Animals; Binding Sites; Brain Diseases, Metabolic, Inborn; Cerebral Cortex; Disease Models, Animal; | 2004 |
L-2-hydroxyglutaric aciduria: characterisation of the molecular defect in a spontaneous canine model.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Animals; Base Pairing; Base Sequence; Bra | 2007 |