alpha-hydroxyglutarate has been researched along with Disease Exacerbation in 11 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " c-MYC also regulates glutamine metabolism and drives progression of asymptomatic precursor plasma cell (PC) malignancies to symptomatic multiple myeloma (MM)." | 3.88 | Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies. ( Dutta, T; Ghosh, T; Gonsalves, WI; Hitosugi, T; Jevremovic, D; Kumar, SK; Nair, KS; Petterson, XM; Ramakrishnan, V; Sakrikar, D; Wellik, L, 2018) |
| "The progression of nonalcoholic fatty liver disease (NAFLD) into severe histological forms (steatohepatitis - NASH) is paralleled by the occurrence of complex molecular processes." | 1.62 | Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease. ( Castaño, GO; Flichman, D; Garaycoechea, M; Pirola, CJ; Sookoian, S, 2021) |
| "We included 252 liver specimens of NAFLD patients - in whom histological disease ranged from mild to severe - which were linked to clinical and biochemical information." | 1.62 | Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease. ( Castaño, GO; Flichman, D; Garaycoechea, M; Pirola, CJ; Sookoian, S, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Pirola, CJ | 1 |
| Garaycoechea, M | 1 |
| Flichman, D | 1 |
| Castaño, GO | 1 |
| Sookoian, S | 1 |
| Xu, F | 1 |
| Hua, Q | 1 |
| Zhang, A | 1 |
| Di, Z | 1 |
| Wang, Y | 1 |
| Zhao, L | 1 |
| Yang, H | 1 |
| Liu, J | 1 |
| Huang, G | 1 |
| Tiburcio, PDB | 1 |
| Xiao, B | 1 |
| Berg, S | 1 |
| Asper, S | 1 |
| Lyne, S | 1 |
| Zhang, Y | 1 |
| Zhu, X | 1 |
| Yan, H | 1 |
| Huang, LE | 1 |
| Gonsalves, WI | 1 |
| Ramakrishnan, V | 1 |
| Hitosugi, T | 1 |
| Ghosh, T | 1 |
| Jevremovic, D | 1 |
| Dutta, T | 1 |
| Sakrikar, D | 1 |
| Petterson, XM | 1 |
| Wellik, L | 1 |
| Kumar, SK | 1 |
| Nair, KS | 1 |
| Han, J | 1 |
| Jackson, D | 1 |
| Holm, J | 1 |
| Turner, K | 1 |
| Ashcraft, P | 1 |
| Wang, X | 1 |
| Cook, B | 1 |
| Arning, E | 1 |
| Genta, RM | 1 |
| Venuprasad, K | 1 |
| Souza, RF | 1 |
| Sweetman, L | 1 |
| Theiss, AL | 1 |
| Juratli, TA | 1 |
| Peitzsch, M | 1 |
| Geiger, K | 1 |
| Schackert, G | 1 |
| Eisenhofer, G | 1 |
| Krex, D | 1 |
| Saidha, S | 1 |
| Murphy, S | 1 |
| McCarthy, P | 1 |
| Mayne, PD | 1 |
| Hennessy, M | 1 |
| Dang, L | 1 |
| White, DW | 1 |
| Gross, S | 1 |
| Bennett, BD | 1 |
| Bittinger, MA | 1 |
| Driggers, EM | 1 |
| Fantin, VR | 1 |
| Jang, HG | 1 |
| Jin, S | 1 |
| Keenan, MC | 1 |
| Marks, KM | 1 |
| Prins, RM | 1 |
| Ward, PS | 1 |
| Yen, KE | 1 |
| Liau, LM | 1 |
| Rabinowitz, JD | 1 |
| Cantley, LC | 1 |
| Thompson, CB | 1 |
| Vander Heiden, MG | 1 |
| Su, SM | 1 |
| Marcel, C | 1 |
| Mallaret, M | 1 |
| Lagha-Boukbiza, O | 1 |
| Kremer, S | 1 |
| Echaniz-Laguna, A | 1 |
| Tranchant, C | 1 |
| Moroni, I | 1 |
| Bugiani, M | 1 |
| D'Incerti, L | 1 |
| Maccagnano, C | 1 |
| Rimoldi, M | 1 |
| Bissola, L | 1 |
| Pollo, B | 1 |
| Finocchiaro, G | 1 |
| Uziel, G | 1 |
| Sass, JO | 1 |
| Jobard, F | 1 |
| Topçu, M | 1 |
| Mahfoud, A | 1 |
| Werlé, E | 1 |
| Cure, S | 1 |
| Al-Sannaa, N | 1 |
| Alshahwan, SA | 1 |
| Bataillard, M | 1 |
| Cimbalistiene, L | 1 |
| Grolik, C | 1 |
| Kemmerich, V | 1 |
| Omran, H | 1 |
| Sztriha, L | 1 |
| Tabache, M | 1 |
| Fischer, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Long-term Observational Study in Patients With Monoclonal Gammopathy of Undetermined Significance[NCT05539079] | 2,000 participants (Anticipated) | Observational | 2023-09-06 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alpha-hydroxyglutarate and Disease Exacerbation
| Article | Year |
|---|---|
L-2-hydroxyglutaric aciduria and brain malignant tumors: a predisposing condition?
Topics: Adolescent; Adult; Astrocytoma; Brain Diseases, Metabolic; Brain Neoplasms; Cerebellar Ataxia; Child | 2004 |
10 other studies available for alpha-hydroxyglutarate and Disease Exacerbation
| Article | Year |
|---|---|
Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Aldehydes; Amino Acids, Branched-Chain; Cytochromes b; Dis | 2021 |
LncRNA AC020978 facilitates non-small cell lung cancer progression by interacting with malate dehydrogenase 2 and activating the AKT pathway.
Topics: A549 Cells; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Disease Progre | 2021 |
Functional requirement of a wild-type allele for mutant IDH1 to suppress anchorage-independent growth through redox homeostasis.
Topics: Animals; Brain; Carcinogenesis; Cell Adhesion; Cells, Cultured; Chickens; Cyclin-Dependent Kinase In | 2018 |
Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies.
Topics: Biomarkers, Tumor; Cell Line, Tumor; Citric Acid Cycle; Disease Progression; DNA-Binding Proteins; G | 2018 |
Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Biopsy; Caco-2 Cells; Cell Movement; Cell Proli | 2018 |
Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas.
Topics: Adult; Aged; Brain Neoplasms; Chromatography, Liquid; Disease Progression; Female; Glioma; Glutarate | 2013 |
L-2-hydroxyglutaric aciduria diagnosed in an adult presenting with acute deterioration.
Topics: Adult; Ataxia; Brain; Disease Progression; Epilepsy; Glutarates; Humans; Lysine; Male; Metabolism, I | 2010 |
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Topics: Arginine; Brain Neoplasms; Catalytic Domain; Cell Line; Crystallography, X-Ray; Disease Progression; | 2009 |
L-2-hydroxyglutaric aciduria diagnosed in a young adult with progressive cerebellar ataxia and facial dyskinesia.
Topics: Alcohol Oxidoreductases; Brain Diseases, Metabolic, Inborn; Cerebellar Ataxia; Diagnosis, Differenti | 2012 |
L-2-hydroxyglutaric aciduria: identification of ten novel mutations in the L2HGDH gene.
Topics: Adult; Alcohol Oxidoreductases; Biomarkers; Brain Diseases, Metabolic, Inborn; Disease Progression; | 2008 |