alpha-hydroxyglutarate has been researched along with Colorectal Neoplasms in 5 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aspirin use is an effective strategy for the chemoprevention of colorectal cancer, even at low doses." | 5.22 | Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial. ( Botma, A; Habermann, N; Klika, KD; Lampe, JW; Liesenfeld, DB; Popanda, O; Potter, JD; Toth, R; Ulrich, CM; Weigel, C, 2016) |
| " Here, we find in colorectal cancer cells that even in the absence of IDH mutation, the levels of D-2HG and its enantiomer L-2HG were elevated through glutamine anaplerosis." | 3.83 | Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. ( Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K, 2016) |
| "Aspirin use is an effective strategy for the chemoprevention of colorectal cancer, even at low doses." | 2.82 | Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial. ( Botma, A; Habermann, N; Klika, KD; Lampe, JW; Liesenfeld, DB; Popanda, O; Potter, JD; Toth, R; Ulrich, CM; Weigel, C, 2016) |
| "Here, we find in colorectal cancer cells that even in the absence of IDH mutation, the levels of D-2HG and its enantiomer L-2HG were elevated through glutamine anaplerosis." | 1.43 | Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. ( Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Modrzejewska, M | 1 |
| Gawronski, M | 1 |
| Gackowski, D | 1 |
| Han, J | 1 |
| Jackson, D | 1 |
| Holm, J | 1 |
| Turner, K | 1 |
| Ashcraft, P | 1 |
| Wang, X | 1 |
| Cook, B | 1 |
| Arning, E | 1 |
| Genta, RM | 1 |
| Venuprasad, K | 1 |
| Souza, RF | 1 |
| Sweetman, L | 1 |
| Theiss, AL | 1 |
| Koseki, J | 2 |
| Colvin, H | 2 |
| Fukusumi, T | 1 |
| Nishida, N | 2 |
| Konno, M | 2 |
| Kawamoto, K | 2 |
| Tsunekuni, K | 2 |
| Matsui, H | 1 |
| Doki, Y | 2 |
| Mori, M | 2 |
| Ishii, H | 2 |
| Liesenfeld, DB | 1 |
| Botma, A | 1 |
| Habermann, N | 1 |
| Toth, R | 1 |
| Weigel, C | 1 |
| Popanda, O | 1 |
| Klika, KD | 1 |
| Potter, JD | 1 |
| Lampe, JW | 1 |
| Ulrich, CM | 1 |
| Haraguchi, N | 1 |
| Takahashi, H | 1 |
| Nishimura, J | 1 |
| Hata, T | 1 |
| Asai, A | 1 |
| Mizushima, T | 1 |
| Satoh, T | 1 |
1 trial available for alpha-hydroxyglutarate and Colorectal Neoplasms
| Article | Year |
|---|---|
Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial.
Topics: Adult; Alcohol Oxidoreductases; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplas | 2016 |
4 other studies available for alpha-hydroxyglutarate and Colorectal Neoplasms
| Article | Year |
|---|---|
Normalization of metabolic data to total thymine content and its application to determination of 2-hydroxyglutarate.
Topics: Aged; Colorectal Neoplasms; Female; Glutarates; Humans; Male; Middle Aged; Tandem Mass Spectrometry; | 2021 |
Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Biopsy; Caco-2 Cells; Cell Movement; Cell Proli | 2018 |
Mathematical analysis predicts imbalanced IDH1/2 expression associates with 2-HG-inactivating β-oxygenation pathway in colorectal cancer.
Topics: Cell Respiration; Colorectal Neoplasms; Computational Biology; Gene Expression Profiling; Gene Expre | 2015 |
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer.
Topics: Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Glutamine; | 2016 |