alpha-hydroxyglutarate has been researched along with Cell Transformation, Neoplastic in 12 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chou, FJ | 1 |
| Liu, Y | 1 |
| Lang, F | 1 |
| Yang, C | 1 |
| Gunn, K | 1 |
| Myllykoski, M | 1 |
| Cao, JZ | 1 |
| Ahmed, M | 1 |
| Huang, B | 1 |
| Rouaisnel, B | 1 |
| Diplas, BH | 1 |
| Levitt, MM | 1 |
| Looper, R | 2 |
| Doench, JG | 1 |
| Ligon, KL | 2 |
| Kornblum, HI | 1 |
| McBrayer, SK | 1 |
| Yan, H | 2 |
| Duy, C | 1 |
| Godley, LA | 1 |
| Koivunen, P | 3 |
| Losman, JA | 3 |
| Mohammad, N | 1 |
| Wong, D | 1 |
| Lum, A | 1 |
| Lin, J | 1 |
| Ho, J | 1 |
| Lee, CH | 1 |
| Yip, S | 1 |
| Lin, P | 1 |
| Luo, Y | 1 |
| Zhu, S | 1 |
| Maggio, D | 1 |
| Yang, H | 3 |
| Hu, C | 1 |
| Wang, J | 1 |
| Zhang, H | 1 |
| Ren, Y | 1 |
| Zhou, X | 1 |
| Mei, C | 1 |
| Ma, L | 1 |
| Xu, W | 1 |
| Ye, L | 1 |
| Zhuang, Z | 1 |
| Jin, J | 1 |
| Tong, H | 1 |
| Rohle, D | 1 |
| Popovici-Muller, J | 1 |
| Palaskas, N | 1 |
| Turcan, S | 1 |
| Grommes, C | 1 |
| Campos, C | 1 |
| Tsoi, J | 1 |
| Clark, O | 1 |
| Oldrini, B | 1 |
| Komisopoulou, E | 1 |
| Kunii, K | 1 |
| Pedraza, A | 1 |
| Schalm, S | 1 |
| Silverman, L | 1 |
| Miller, A | 1 |
| Wang, F | 1 |
| Chen, Y | 1 |
| Kernytsky, A | 1 |
| Rosenblum, MK | 1 |
| Liu, W | 1 |
| Biller, SA | 1 |
| Su, SM | 1 |
| Brennan, CW | 1 |
| Chan, TA | 1 |
| Graeber, TG | 1 |
| Yen, KE | 1 |
| Mellinghoff, IK | 1 |
| Flavahan, WA | 1 |
| Drier, Y | 1 |
| Liau, BB | 1 |
| Gillespie, SM | 1 |
| Venteicher, AS | 1 |
| Stemmer-Rachamimov, AO | 1 |
| Suvà, ML | 1 |
| Bernstein, BE | 1 |
| Fujii, T | 1 |
| Khawaja, MR | 1 |
| DiNardo, CD | 1 |
| Atkins, JT | 1 |
| Janku, F | 1 |
| Johannessen, TA | 1 |
| Mukherjee, J | 1 |
| Viswanath, P | 1 |
| Ohba, S | 1 |
| Ronen, SM | 1 |
| Bjerkvig, R | 1 |
| Pieper, RO | 1 |
| Bhagwat, N | 1 |
| Levine, RL | 1 |
| Lee, S | 2 |
| Duncan, CG | 1 |
| Lopez, G | 1 |
| Lu, G | 1 |
| Ramkissoon, S | 1 |
| Joensuu, P | 1 |
| Bergmann, U | 1 |
| Gross, S | 1 |
| Travins, J | 1 |
| Weiss, S | 1 |
| Verhaak, RG | 1 |
| Kaelin, WG | 2 |
| Ye, D | 1 |
| Guan, KL | 1 |
| Xiong, Y | 1 |
| Looper, RE | 1 |
| Schneider, RK | 1 |
| McMahon, C | 1 |
| Cowley, GS | 1 |
| Root, DE | 1 |
| Ebert, BL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence, Correlation With Other Mutant Genes and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia. The European IDH Research Alliance[NCT04369287] | 654 participants (Anticipated) | Observational | 2016-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for alpha-hydroxyglutarate and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
D-2-Hydroxyglutarate in Glioma Biology.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Brain Neoplasms; Carcinogenesis; Cell Transformation, | 2021 |
Targeting isocitrate dehydrogenase (IDH) in cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cell Differe | 2016 |
IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives.
Topics: Cell Differentiation; Cell Transformation, Neoplastic; DNA Methylation; Glutarates; Histone Demethyl | 2012 |
9 other studies available for alpha-hydroxyglutarate and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.
Topics: Cell Transformation, Neoplastic; DNA Methylation; Glioma; Glutarates; Histone Demethylases; Histones | 2023 |
Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d-2-hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma.
Topics: Adult; Aged; Aged, 80 and over; Bone Neoplasms; Cell Transformation, Neoplastic; Chondrosarcoma; Fem | 2020 |
Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cell Transformation, Neoplastic; Cohort Studies; Female; | 2018 |
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Topics: Animals; Benzeneacetamides; Cell Differentiation; Cell Transformation, Neoplastic; Enzyme Inhibitors | 2013 |
Insulator dysfunction and oncogene activation in IDH mutant gliomas.
Topics: Base Sequence; Binding Sites; CCCTC-Binding Factor; Cell Cycle Proteins; Cell Proliferation; Cell Tr | 2016 |
Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis.
Topics: Astrocytes; Benzeneacetamides; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2016 |
Metabolic syndromes and malignant transformation: where the twain shall meet.
Topics: Cell Transformation, Neoplastic; Glioma; Glutarates; Humans; Isocitrate Dehydrogenase; Leukemia, Mye | 2010 |
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
Topics: Astrocytes; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Dioxyg | 2012 |
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Glutarates; Hematopoiesis; Humans; Isocitrate Deh | 2013 |