alpha-hydroxyglutarate has been researched along with Cardiomyopathies in 5 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hematologic malignancies are frequently associated with cardiac pathologies." | 1.43 | Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. ( Goodell, MA; Harmancey, R; Karlstaedt, A; Taegtmeyer, H; Vasquez, H; Vitrac, H; Wang, JH; Zhang, X, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ribeiro, RT | 1 |
| Roginski, AC | 1 |
| Marschner, RA | 1 |
| Wajner, SM | 1 |
| Castilho, RF | 1 |
| Amaral, AU | 1 |
| Wajner, M | 1 |
| Akbay, EA | 1 |
| Moslehi, J | 1 |
| Christensen, CL | 1 |
| Saha, S | 1 |
| Tchaicha, JH | 1 |
| Ramkissoon, SH | 1 |
| Stewart, KM | 1 |
| Carretero, J | 1 |
| Kikuchi, E | 1 |
| Zhang, H | 1 |
| Cohoon, TJ | 1 |
| Murray, S | 1 |
| Liu, W | 1 |
| Uno, K | 1 |
| Fisch, S | 1 |
| Jones, K | 1 |
| Gurumurthy, S | 1 |
| Gliser, C | 1 |
| Choe, S | 1 |
| Keenan, M | 1 |
| Son, J | 1 |
| Stanley, I | 1 |
| Losman, JA | 1 |
| Padera, R | 1 |
| Bronson, RT | 1 |
| Asara, JM | 1 |
| Abdel-Wahab, O | 1 |
| Amrein, PC | 1 |
| Fathi, AT | 1 |
| Danial, NN | 1 |
| Kimmelman, AC | 1 |
| Kung, AL | 1 |
| Ligon, KL | 1 |
| Yen, KE | 1 |
| Kaelin, WG | 1 |
| Bardeesy, N | 1 |
| Wong, KK | 1 |
| Karlstaedt, A | 1 |
| Zhang, X | 1 |
| Vitrac, H | 1 |
| Harmancey, R | 1 |
| Vasquez, H | 1 |
| Wang, JH | 1 |
| Goodell, MA | 1 |
| Taegtmeyer, H | 1 |
| Baker, NS | 1 |
| Sarnat, HB | 1 |
| Jack, RM | 1 |
| Patterson, K | 1 |
| Shaw, DW | 1 |
| Herndon, SP | 1 |
| Wajne, M | 1 |
| Vargas, CR | 1 |
| Funayama, C | 1 |
| Fernandez, A | 1 |
| Elias, ML | 1 |
| Goodman, SI | 1 |
| Jakobs, C | 1 |
| van der Knaap, MS | 1 |
5 other studies available for alpha-hydroxyglutarate and Cardiomyopathies
| Article | Year |
|---|---|
Disruption of mitochondrial bioenergetics, calcium retention capacity and cell viability caused by D-2-hydroxyglutaric acid in the heart.
Topics: Animals; Calcium; Cardiomyopathies; Cell Survival; Creatine Kinase; Energy Metabolism; Rats | 2023 |
D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.
Topics: Animals; Cardiomyopathies; Cell Line; Gene Expression Profiling; Gene Expression Regulation, Develop | 2014 |
Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.
Topics: Acetylation; Animals; ATP Citrate (pro-S)-Lyase; Cardiomyopathies; Glutarates; Hematologic Neoplasms | 2016 |
D-2-hydroxyglutaric aciduria: hypotonia, cortical blindness, seizures, cardiomyopathy, and cylindrical spirals in skeletal muscle.
Topics: Amino Acid Metabolism, Inborn Errors; Blindness; Brain Diseases; Cardiomyopathies; Electroencephalog | 1997 |
D-2-Hydroxyglutaric aciduria in a patient with a severe clinical phenotype and unusual MRI findings.
Topics: Brain; Cardiomyopathies; Cells, Cultured; Citrate (si)-Synthase; Electron Transport Complex IV; Fibr | 2002 |