Page last updated: 2024-10-15

alpha-hydroxyglutarate and Cardiomyopathies, Primary

alpha-hydroxyglutarate has been researched along with Cardiomyopathies, Primary in 5 studies

2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Hematologic malignancies are frequently associated with cardiac pathologies."1.43Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. ( Goodell, MA; Harmancey, R; Karlstaedt, A; Taegtmeyer, H; Vasquez, H; Vitrac, H; Wang, JH; Zhang, X, 2016)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Ribeiro, RT1
Roginski, AC1
Marschner, RA1
Wajner, SM1
Castilho, RF1
Amaral, AU1
Wajner, M1
Akbay, EA1
Moslehi, J1
Christensen, CL1
Saha, S1
Tchaicha, JH1
Ramkissoon, SH1
Stewart, KM1
Carretero, J1
Kikuchi, E1
Zhang, H1
Cohoon, TJ1
Murray, S1
Liu, W1
Uno, K1
Fisch, S1
Jones, K1
Gurumurthy, S1
Gliser, C1
Choe, S1
Keenan, M1
Son, J1
Stanley, I1
Losman, JA1
Padera, R1
Bronson, RT1
Asara, JM1
Abdel-Wahab, O1
Amrein, PC1
Fathi, AT1
Danial, NN1
Kimmelman, AC1
Kung, AL1
Ligon, KL1
Yen, KE1
Kaelin, WG1
Bardeesy, N1
Wong, KK1
Karlstaedt, A1
Zhang, X1
Vitrac, H1
Harmancey, R1
Vasquez, H1
Wang, JH1
Goodell, MA1
Taegtmeyer, H1
Baker, NS1
Sarnat, HB1
Jack, RM1
Patterson, K1
Shaw, DW1
Herndon, SP1
Wajne, M1
Vargas, CR1
Funayama, C1
Fernandez, A1
Elias, ML1
Goodman, SI1
Jakobs, C1
van der Knaap, MS1

Other Studies

5 other studies available for alpha-hydroxyglutarate and Cardiomyopathies, Primary

ArticleYear
Disruption of mitochondrial bioenergetics, calcium retention capacity and cell viability caused by D-2-hydroxyglutaric acid in the heart.
    Biochimie, 2023, Volume: 207

    Topics: Animals; Calcium; Cardiomyopathies; Cell Survival; Creatine Kinase; Energy Metabolism; Rats

2023
D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.
    Genes & development, 2014, Mar-01, Volume: 28, Issue:5

    Topics: Animals; Cardiomyopathies; Cell Line; Gene Expression Profiling; Gene Expression Regulation, Develop

2014
Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 09-13, Volume: 113, Issue:37

    Topics: Acetylation; Animals; ATP Citrate (pro-S)-Lyase; Cardiomyopathies; Glutarates; Hematologic Neoplasms

2016
D-2-hydroxyglutaric aciduria: hypotonia, cortical blindness, seizures, cardiomyopathy, and cylindrical spirals in skeletal muscle.
    Journal of child neurology, 1997, Volume: 12, Issue:1

    Topics: Amino Acid Metabolism, Inborn Errors; Blindness; Brain Diseases; Cardiomyopathies; Electroencephalog

1997
D-2-Hydroxyglutaric aciduria in a patient with a severe clinical phenotype and unusual MRI findings.
    Journal of inherited metabolic disease, 2002, Volume: 25, Issue:1

    Topics: Brain; Cardiomyopathies; Cells, Cultured; Citrate (si)-Synthase; Electron Transport Complex IV; Fibr

2002