alpha-hydroxyglutarate has been researched along with Bone Cancer in 8 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, utilizing patient-derived chondrosarcoma cells harboring endogenous mutations in IDH1 and IDH2, we report that 2-HG can be rapidly generated from glutamine in vitro." | 3.85 | In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors. ( Correa, FM; Cross, JR; Di Gialleonardo, V; Granlund, KL; Keshari, KR; Lui, H; Miloushev, VZ; Poot, AJ; Salamanca-Cardona, L; Shah, H; Tee, SS; Thompson, CB, 2017) |
| "Chondrosarcoma is the second most common malignant bone tumor." | 1.51 | Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma. ( Aikawa, Y; Chuman, H; Endo, M; Fujita, S; Fujiwara, T; Fukushima, S; Hattori, A; Hirose, T; Ishikawa, T; Iwamoto, Y; Katsumoto, T; Kawai, A; Kimura, A; Kitabayashi, I; Machida, Y; Matsumoto, Y; Matsunaga, H; Nakagawa, M; Nakashima, Y; Nakatani, F; Ogawara, Y; Seki, T; Setsu, N; Shimada, E; Soga, T; Yahiro, K; Yamagata, K; Yokoyama, N, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Nakagawa, M | 1 |
| Nakatani, F | 1 |
| Matsunaga, H | 1 |
| Seki, T | 1 |
| Endo, M | 1 |
| Ogawara, Y | 1 |
| Machida, Y | 1 |
| Katsumoto, T | 1 |
| Yamagata, K | 1 |
| Hattori, A | 1 |
| Fujita, S | 1 |
| Aikawa, Y | 1 |
| Ishikawa, T | 1 |
| Soga, T | 1 |
| Kawai, A | 1 |
| Chuman, H | 1 |
| Yokoyama, N | 1 |
| Fukushima, S | 1 |
| Yahiro, K | 1 |
| Kimura, A | 1 |
| Shimada, E | 1 |
| Hirose, T | 1 |
| Fujiwara, T | 1 |
| Setsu, N | 1 |
| Matsumoto, Y | 1 |
| Iwamoto, Y | 1 |
| Nakashima, Y | 1 |
| Kitabayashi, I | 1 |
| Mohammad, N | 1 |
| Wong, D | 1 |
| Lum, A | 1 |
| Lin, J | 1 |
| Ho, J | 1 |
| Lee, CH | 1 |
| Yip, S | 1 |
| Salamanca-Cardona, L | 1 |
| Shah, H | 1 |
| Poot, AJ | 1 |
| Correa, FM | 1 |
| Di Gialleonardo, V | 1 |
| Lui, H | 1 |
| Miloushev, VZ | 1 |
| Granlund, KL | 1 |
| Tee, SS | 1 |
| Cross, JR | 2 |
| Thompson, CB | 2 |
| Keshari, KR | 1 |
| Guilhamon, P | 1 |
| Eskandarpour, M | 1 |
| Halai, D | 1 |
| Wilson, GA | 1 |
| Feber, A | 1 |
| Teschendorff, AE | 1 |
| Gomez, V | 1 |
| Hergovich, A | 1 |
| Tirabosco, R | 1 |
| Fernanda Amary, M | 1 |
| Baumhoer, D | 1 |
| Jundt, G | 1 |
| Ross, MT | 1 |
| Flanagan, AM | 1 |
| Beck, S | 1 |
| Lu, C | 1 |
| Venneti, S | 1 |
| Akalin, A | 1 |
| Fang, F | 1 |
| Ward, PS | 1 |
| Dematteo, RG | 1 |
| Intlekofer, AM | 1 |
| Chen, C | 1 |
| Ye, J | 1 |
| Hameed, M | 1 |
| Nafa, K | 1 |
| Agaram, NP | 1 |
| Khanin, R | 1 |
| Mason, CE | 1 |
| Healey, JH | 1 |
| Lowe, SW | 1 |
| Schwartz, GK | 1 |
| Melnick, A | 1 |
| Kato Kaneko, M | 1 |
| Liu, X | 1 |
| Oki, H | 1 |
| Ogasawara, S | 1 |
| Nakamura, T | 1 |
| Saidoh, N | 1 |
| Tsujimoto, Y | 1 |
| Matsuyama, Y | 1 |
| Uruno, A | 1 |
| Sugawara, M | 1 |
| Tsuchiya, T | 1 |
| Yamakawa, M | 1 |
| Yamamoto, M | 1 |
| Takagi, M | 1 |
| Kato, Y | 1 |
| Suijker, J | 1 |
| Oosting, J | 1 |
| Koornneef, A | 1 |
| Struys, EA | 1 |
| Salomons, GS | 1 |
| Schaap, FG | 1 |
| Waaijer, CJ | 1 |
| Wijers-Koster, PM | 1 |
| Briaire-de Bruijn, IH | 1 |
| Haazen, L | 1 |
| Riester, SM | 1 |
| Dudakovic, A | 1 |
| Danen, E | 1 |
| Cleton-Jansen, AM | 1 |
| van Wijnen, AJ | 1 |
| Bovée, JV | 1 |
| Larnaout, A | 1 |
| Amouri, R | 1 |
| Neji, S | 1 |
| Zouari, M | 1 |
| Kaabachi, N | 1 |
| Hentati, F | 1 |
1 review available for alpha-hydroxyglutarate and Bone Cancer
| Article | Year |
|---|---|
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.
Topics: Bile Duct Neoplasms; Bone Neoplasms; Central Nervous System Neoplasms; Cholangiocarcinoma; Chondrosa | 2013 |
7 other studies available for alpha-hydroxyglutarate and Bone Cancer
| Article | Year |
|---|---|
Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma.
Topics: Bone Neoplasms; Cell Cycle Checkpoints; Cell Differentiation; Cell Proliferation; Chondrosarcoma; En | 2019 |
Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d-2-hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma.
Topics: Adult; Aged; Aged, 80 and over; Bone Neoplasms; Cell Transformation, Neoplastic; Chondrosarcoma; Fem | 2020 |
In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors.
Topics: Animals; Biomarkers, Tumor; Bone Neoplasms; Cell Line, Tumor; Chondrosarcoma; Female; Glutamine; Glu | 2017 |
Induction of sarcomas by mutant IDH2.
Topics: Animals; Bone Neoplasms; Cell Differentiation; Cell Line; Chondrosarcoma; CpG Islands; DNA Methylati | 2013 |
Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Base Sequence; Bone Neoplasms; Female; Giant Cell Tumor o | 2014 |
Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines.
Topics: Blotting, Western; Bone Neoplasms; Cell Line, Tumor; Chondrosarcoma; Chromatography, Liquid; DNA Mut | 2015 |
Osteoma of the calvaria in L-2-hydroxyglutaric aciduria.
Topics: Adult; Bone Neoplasms; Brain; Brain Diseases, Metabolic, Inborn; Creatinine; Dementia, Vascular; Glu | 2007 |