alpha-hydroxyglutarate has been researched along with Astrocytoma in 10 studies
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous ex vivo spectroscopic data from tissue samples revealed differences in phospholipid metabolites between isocitrate dehydrogenase mutated (IDHmut) and IDH wildtype (IDHwt) gliomas." | 3.91 | In vivo Metabolic Profiles as Determined by ( Bähr, O; Franz, K; Hattingen, E; Pilatus, U; Steinbach, J; Wenger, KJ, 2019) |
| "Mixed oligoastrocytoma is losing popularity as a diagnostic term because most cases will fall into either the FA or OD category." | 2.52 | Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas. ( Macaulay, RJ, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, C | 1 |
| Zhang, L | 1 |
| Sorensen, MD | 1 |
| Reifenberger, G | 1 |
| Kristensen, BW | 1 |
| McIntyre, TM | 1 |
| Lin, F | 1 |
| Wenger, KJ | 1 |
| Hattingen, E | 1 |
| Franz, K | 1 |
| Steinbach, J | 1 |
| Bähr, O | 1 |
| Pilatus, U | 1 |
| Karpel-Massler, G | 1 |
| Ishida, CT | 1 |
| Bianchetti, E | 1 |
| Zhang, Y | 1 |
| Shu, C | 1 |
| Tsujiuchi, T | 1 |
| Banu, MA | 1 |
| Garcia, F | 1 |
| Roth, KA | 1 |
| Bruce, JN | 1 |
| Canoll, P | 1 |
| Siegelin, MD | 1 |
| An, Z | 1 |
| Tiwari, V | 1 |
| Baxter, J | 1 |
| Levy, M | 1 |
| Hatanpaa, KJ | 1 |
| Pan, E | 1 |
| Maher, EA | 1 |
| Patel, TR | 1 |
| Mickey, BE | 1 |
| Choi, C | 1 |
| Patay, Z | 1 |
| Orr, BA | 1 |
| Shulkin, BL | 1 |
| Hwang, SN | 1 |
| Ying, Y | 1 |
| Broniscer, A | 1 |
| Boop, FA | 1 |
| Ellison, DW | 1 |
| Macaulay, RJ | 1 |
| van Lith, SA | 1 |
| Navis, AC | 1 |
| Lenting, K | 1 |
| Verrijp, K | 1 |
| Schepens, JT | 1 |
| Hendriks, WJ | 1 |
| Schubert, NA | 1 |
| Venselaar, H | 1 |
| Wevers, RA | 1 |
| van Rooij, A | 1 |
| Wesseling, P | 1 |
| Molenaar, RJ | 1 |
| van Noorden, CJ | 1 |
| Pusch, S | 2 |
| Tops, B | 1 |
| Leenders, WP | 1 |
| Krausert, S | 1 |
| Fischer, V | 1 |
| Balss, J | 1 |
| Ott, M | 1 |
| Schrimpf, D | 1 |
| Capper, D | 1 |
| Sahm, F | 1 |
| Eisel, J | 1 |
| Beck, AC | 1 |
| Jugold, M | 1 |
| Eichwald, V | 1 |
| Kaulfuss, S | 1 |
| Panknin, O | 1 |
| Rehwinkel, H | 1 |
| Zimmermann, K | 1 |
| Hillig, RC | 1 |
| Guenther, J | 1 |
| Toschi, L | 1 |
| Neuhaus, R | 1 |
| Haegebart, A | 1 |
| Hess-Stumpp, H | 1 |
| Bauser, M | 1 |
| Wick, W | 1 |
| Unterberg, A | 1 |
| Herold-Mende, C | 1 |
| Platten, M | 1 |
| von Deimling, A | 1 |
| Jin, G | 1 |
| Reitman, ZJ | 1 |
| Duncan, CG | 1 |
| Spasojevic, I | 1 |
| Gooden, DM | 1 |
| Rasheed, BA | 1 |
| Yang, R | 1 |
| Lopez, GY | 1 |
| He, Y | 1 |
| McLendon, RE | 1 |
| Bigner, DD | 1 |
| Yan, H | 1 |
| Moroni, I | 1 |
| Bugiani, M | 1 |
| D'Incerti, L | 1 |
| Maccagnano, C | 1 |
| Rimoldi, M | 1 |
| Bissola, L | 1 |
| Pollo, B | 1 |
| Finocchiaro, G | 1 |
| Uziel, G | 1 |
2 reviews available for alpha-hydroxyglutarate and Astrocytoma
| Article | Year |
|---|---|
Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas.
Topics: Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; DNA Helicases; Genes, p53; Glioma; Glutarates; Huma | 2015 |
L-2-hydroxyglutaric aciduria and brain malignant tumors: a predisposing condition?
Topics: Adolescent; Adult; Astrocytoma; Brain Diseases, Metabolic; Brain Neoplasms; Cerebellar Ataxia; Child | 2004 |
8 other studies available for alpha-hydroxyglutarate and Astrocytoma
| Article | Year |
|---|---|
D-2-hydroxyglutarate regulates human brain vascular endothelial cell proliferation and barrier function.
Topics: Astrocytoma; Brain; Brain Neoplasms; Cell Proliferation; Endothelial Cells; Glioma; Humans; Isocitra | 2023 |
In vivo Metabolic Profiles as Determined by
Topics: Adult; Aged; Analysis of Variance; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Diagnosis, Diffe | 2019 |
Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Astrocytoma; bcl-X Protein; Brain Neop | 2017 |
3D high-resolution imaging of 2-hydroxyglutarate in glioma patients using DRAG-EPSI at 3T in vivo.
Topics: Acoustics; Adult; Algorithms; Astrocytoma; Brain; Brain Mapping; Brain Neoplasms; Contrast Media; Ec | 2019 |
Successive distinct high-grade gliomas in L-2-hydroxyglutaric aciduria.
Topics: Alcohol Oxidoreductases; Astrocytoma; Biopsy; Brain Diseases, Metabolic, Inborn; Brain Neoplasms; Er | 2015 |
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.
Topics: Animals; Astrocytoma; Base Sequence; Binding Sites; Brain Neoplasms; Cell Line, Tumor; Glutarates; H | 2016 |
Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Astrocytoma; Benzimidazoles; Brain Neoplasms; Cel | 2017 |
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Topics: Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Genotype; Glioblastoma; Glioma; Glutarates; Humans; | 2013 |