alpha-endorphin has been researched along with Schizophrenia* in 1 studies
1 other study(ies) available for alpha-endorphin and Schizophrenia
| Article | Year |
|---|---|
Increased concentration of alpha- and gamma-endorphin in post mortem hypothalamic tissue of schizophrenic patients.
The concentrations of alpha-, beta- and gamma-endorphin were determined by radioimmunoassay in HPLC fractionated extracts of post mortem hypothalamic tissue obtained from schizophrenic patients and controls. The hypothalamic concentration of alpha- and gamma-endorphin was significantly higher in patients than in controls (+72.9% and +50.5% respectively). No difference was found in the concentration of beta-endorphin, the putative precursor of alpha- and gamma-endorphins. These results suggest a deviant metabolism of beta-endorphin in the brain of schizophrenic patients. Whether this phenomenon is related to the psychopathology, or is a consequence of ante mortem farmacotherapy, remains to be established. Topics: Adult; Aged; Aged, 80 and over; alpha-Endorphin; beta-Endorphin; Chromatography, High Pressure Liquid; Endorphins; Female; gamma-Endorphin; Humans; Hypothalamus; Male; Middle Aged; Radioimmunoassay; Schizophrenia | 1988 |