alpha-cyclodextrin has been researched along with Candidiasis* in 1 studies
1 other study(ies) available for alpha-cyclodextrin and Candidiasis
Article | Year |
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Supramolecular Chitosan Micro-Platelets Synergistically Enhance Anti-Candida albicans Activity of Amphotericin B Using an Immunocompetent Murine Model.
The aim of this work is to design new chitosan conjugates able to self-organize in aqueous solution in the form of micrometer-size platelets. When mixed with amphotericin B deoxycholate (AmB-DOC), micro-platelets act as a drug booster allowing further improvement in AmB-DOC anti-Candida albicans activity.. Micro-platelets were obtained by mixing oleoyl chitosan and α-cyclodextrin in water. The formulation is specifically-engineered for mucosal application by dispersing chitosan micro-platelets into thermosensitive pluronic. These results demonstrate for the first time the ability of flattened chitosan micro-platelets to have synergistic activity with AmB-DOC against C. albicans candidiasis and highlight the importance of rheological and mucoadhesive behaviors of hydrogels in the efficacy of the treatment. Topics: alpha-Cyclodextrins; Amphotericin B; Animals; Antifungal Agents; Blood Platelets; Candida albicans; Candidiasis; Chemistry, Pharmaceutical; Chitosan; Deoxycholic Acid; Disease Models, Animal; Drug Combinations; Female; Hydrogels; Mice; Mice, Inbred BALB C; Mucous Membrane; Nanoparticles; Poloxamer; Swine | 2017 |