alpha-cyano-4-hydroxycinnamate has been researched along with Melanoma in 4 studies
alpha-cyano-4-hydroxycinnamate: specific inhibitor of pyruvate transport in rat liver mitochondria & human erythrocytes; structure
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin treatment inhibited both EMT markers and Oxphos and, when its concentration raised to 10 mM, it induced a striking inhibition of proliferation and colony formation of acidic melanoma cells, both grown in protons enriched medium or lactic acidosis." | 5.43 | Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. ( Bianchini, F; Calorini, L; Del Rosso, M; Giannoni, E; Margheri, F; Peppicelli, S; Toti, A, 2016) |
| "The authors performed this study to evaluate the selective acidification of a human melanoma xenograft in mice with severe combined immunodeficiency with the induction of hyperglycemia (mean blood glucose level +/- standard error of the mean, 26 mmol/L +/- 1) and the intraperitoneal administration of metaiodobenzylguanidine (MIBG, 30 mg/kg), alpha-cyano-4-hydroxycinnamate (CNCn, 300 mg/kg), lonidamine (100 mg/kg), cariporide (HOE642, 160 mg/kg), or 4." | 3.71 | Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport. ( Bansal, N; Glickson, JD; Leeper, DB; Pickup, S; Zhou, R, 2001) |
| "Metformin treatment inhibited both EMT markers and Oxphos and, when its concentration raised to 10 mM, it induced a striking inhibition of proliferation and colony formation of acidic melanoma cells, both grown in protons enriched medium or lactic acidosis." | 1.43 | Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. ( Bianchini, F; Calorini, L; Del Rosso, M; Giannoni, E; Margheri, F; Peppicelli, S; Toti, A, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peppicelli, S | 1 |
| Toti, A | 1 |
| Giannoni, E | 1 |
| Bianchini, F | 1 |
| Margheri, F | 1 |
| Del Rosso, M | 1 |
| Calorini, L | 1 |
| Coss, RA | 1 |
| Storck, CW | 1 |
| Daskalakis, C | 1 |
| Berd, D | 1 |
| Wahl, ML | 1 |
| Kang, JH | 1 |
| Toita, R | 1 |
| Oishi, J | 1 |
| Niidome, T | 1 |
| Katayama, Y | 1 |
| Zhou, R | 1 |
| Bansal, N | 1 |
| Leeper, DB | 1 |
| Pickup, S | 1 |
| Glickson, JD | 1 |
4 other studies available for alpha-cyano-4-hydroxycinnamate and Melanoma
| Article | Year |
|---|---|
Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation.
Topics: Acidosis, Lactic; Adaptation, Physiological; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proli | 2016 |
Intracellular acidification abrogates the heat shock response and compromises survival of human melanoma cells.
Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Coloring Agents; Coumaric Acids; Electrophoresis | 2003 |
Effect of the addition of diammonium citrate to alpha-cyano-4-hydroxycinnamic acid (CHCA) matrix for the detection of phosphorylated peptide in phosphorylation reactions using cell and tissue lysates.
Topics: Animals; Cell Line, Tumor; Citric Acid; Coumaric Acids; CSK Tyrosine-Protein Kinase; Male; Melanoma; | 2007 |
Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport.
Topics: 3-Iodobenzylguanidine; Animals; Cell Respiration; Coumaric Acids; Glycolysis; Humans; Hydrogen-Ion C | 2001 |