alpha-cyano-4-hydroxycinnamate has been researched along with Malignant Melanoma in 4 studies
alpha-cyano-4-hydroxycinnamate: specific inhibitor of pyruvate transport in rat liver mitochondria & human erythrocytes; structure
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin treatment inhibited both EMT markers and Oxphos and, when its concentration raised to 10 mM, it induced a striking inhibition of proliferation and colony formation of acidic melanoma cells, both grown in protons enriched medium or lactic acidosis." | 5.43 | Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. ( Bianchini, F; Calorini, L; Del Rosso, M; Giannoni, E; Margheri, F; Peppicelli, S; Toti, A, 2016) |
| "The authors performed this study to evaluate the selective acidification of a human melanoma xenograft in mice with severe combined immunodeficiency with the induction of hyperglycemia (mean blood glucose level +/- standard error of the mean, 26 mmol/L +/- 1) and the intraperitoneal administration of metaiodobenzylguanidine (MIBG, 30 mg/kg), alpha-cyano-4-hydroxycinnamate (CNCn, 300 mg/kg), lonidamine (100 mg/kg), cariporide (HOE642, 160 mg/kg), or 4." | 3.71 | Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport. ( Bansal, N; Glickson, JD; Leeper, DB; Pickup, S; Zhou, R, 2001) |
| "Metformin treatment inhibited both EMT markers and Oxphos and, when its concentration raised to 10 mM, it induced a striking inhibition of proliferation and colony formation of acidic melanoma cells, both grown in protons enriched medium or lactic acidosis." | 1.43 | Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. ( Bianchini, F; Calorini, L; Del Rosso, M; Giannoni, E; Margheri, F; Peppicelli, S; Toti, A, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peppicelli, S | 1 |
| Toti, A | 1 |
| Giannoni, E | 1 |
| Bianchini, F | 1 |
| Margheri, F | 1 |
| Del Rosso, M | 1 |
| Calorini, L | 1 |
| Coss, RA | 1 |
| Storck, CW | 1 |
| Daskalakis, C | 1 |
| Berd, D | 1 |
| Wahl, ML | 1 |
| Kang, JH | 1 |
| Toita, R | 1 |
| Oishi, J | 1 |
| Niidome, T | 1 |
| Katayama, Y | 1 |
| Zhou, R | 1 |
| Bansal, N | 1 |
| Leeper, DB | 1 |
| Pickup, S | 1 |
| Glickson, JD | 1 |
4 other studies available for alpha-cyano-4-hydroxycinnamate and Malignant Melanoma
| Article | Year |
|---|---|
Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation.
Topics: Acidosis, Lactic; Adaptation, Physiological; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proli | 2016 |
Intracellular acidification abrogates the heat shock response and compromises survival of human melanoma cells.
Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Coloring Agents; Coumaric Acids; Electrophoresis | 2003 |
Effect of the addition of diammonium citrate to alpha-cyano-4-hydroxycinnamic acid (CHCA) matrix for the detection of phosphorylated peptide in phosphorylation reactions using cell and tissue lysates.
Topics: Animals; Cell Line, Tumor; Citric Acid; Coumaric Acids; CSK Tyrosine-Protein Kinase; Male; Melanoma; | 2007 |
Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport.
Topics: 3-Iodobenzylguanidine; Animals; Cell Respiration; Coumaric Acids; Glycolysis; Humans; Hydrogen-Ion C | 2001 |