alpha-cyano-4-hydroxycinnamate has been researched along with Breast Neoplasms in 7 studies
alpha-cyano-4-hydroxycinnamate: specific inhibitor of pyruvate transport in rat liver mitochondria & human erythrocytes; structure
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to determine the efficacy of AZD3965 (a specific inhibitor of MCT1) and α-cyano-4-hydroxycinnamic acid (CHC, a nonspecific inhibitor of MCTs) in the murine 4T1 tumor model of triple-negative breast cancer (TNBC)." | 3.96 | In Vitro and In Vivo Efficacy of AZD3965 and Alpha-Cyano-4-Hydroxycinnamic Acid in the Murine 4T1 Breast Tumor Model. ( Guan, X; Morris, ME, 2020) |
| "This study showed that breast cancer cells tolerate and use lactate at clinically relevant concentrations in vitro (± glucose) and in vivo." | 1.39 | Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. ( Chi, JT; Dewhirst, MW; Kennedy, KM; Landon, CD; Pizzo, S; Ribeiro, A; Richardson, R; Scarbrough, PM; Schroeder, T; Sonveaux, P; Yuan, H, 2013) |
| "Finally, using human breast cancer tumor samples, we directly confirmed that the enzymes associated with ketone body production (HMGCS2, HMGCL and BDH1) were preferentially expressed in the tumor stroma." | 1.38 | Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. ( Howell, A; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Sotgia, F; Whitaker-Menezes, D, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, X | 2 |
| Morris, ME | 2 |
| Rodriguez-Cruz, V | 1 |
| Kennedy, KM | 1 |
| Scarbrough, PM | 1 |
| Ribeiro, A | 1 |
| Richardson, R | 1 |
| Yuan, H | 1 |
| Sonveaux, P | 1 |
| Landon, CD | 1 |
| Chi, JT | 1 |
| Pizzo, S | 1 |
| Schroeder, T | 1 |
| Dewhirst, MW | 1 |
| Morais-Santos, F | 1 |
| Miranda-Gonçalves, V | 1 |
| Pinheiro, S | 1 |
| Vieira, AF | 1 |
| Paredes, J | 1 |
| Schmitt, FC | 1 |
| Baltazar, F | 1 |
| Pinheiro, C | 1 |
| Diers, AR | 1 |
| Broniowska, KA | 1 |
| Chang, CF | 1 |
| Hogg, N | 1 |
| Martinez-Outschoorn, UE | 1 |
| Lin, Z | 1 |
| Whitaker-Menezes, D | 1 |
| Howell, A | 1 |
| Lisanti, MP | 1 |
| Sotgia, F | 1 |
| Wahl, ML | 1 |
| Pooler, PM | 1 |
| Briand, P | 1 |
| Leeper, DB | 1 |
| Owen, CS | 1 |
7 other studies available for alpha-cyano-4-hydroxycinnamate and Breast Neoplasms
| Article | Year |
|---|---|
In Vitro and In Vivo Efficacy of AZD3965 and Alpha-Cyano-4-Hydroxycinnamic Acid in the Murine 4T1 Breast Tumor Model.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coumaric Acids; Dose-Response Relationship, Drug; Femal | 2020 |
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coumaric Acids; Drug Screening Assays, Antitumor; Femal | 2019 |
Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
Topics: Adult; Aged; Alanine; Animals; Breast Neoplasms; Cell Death; Cell Hypoxia; Cell Line, Tumor; Coumari | 2013 |
Differential sensitivities to lactate transport inhibitors of breast cancer cell lines.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coumaric Acids; Female; H | 2014 |
Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Coumaric Acids; Female; Hu | 2012 |
Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
Topics: Acetyl-CoA C-Acetyltransferase; Breast Neoplasms; Caveolin 1; Cell Line; Chaperonin 60; Coculture Te | 2012 |
Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Breast; Breast Neoplasms; Cell Line, Transformed; | 2000 |