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alpha-cyano-4-hydroxycinnamate and Brain Ischemia

alpha-cyano-4-hydroxycinnamate has been researched along with Brain Ischemia in 4 studies

alpha-cyano-4-hydroxycinnamate: specific inhibitor of pyruvate transport in rat liver mitochondria & human erythrocytes; structure

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models."5.31Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001)
" To test the role of lactate as an aerobic energy substrate postischemia in vivo, we employed the cardiac-arrest-induced transient global cerebral ischemia (TGI) rat model and the monocarboxylate transporter inhibitor alpha-cyano-4-hydroxycinnamate (4-CIN)."3.71Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia. ( Miller, JJ; Payne, RS; Rigor, BM; Schurr, A; Tseng, MT, 2001)
"In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models."1.31Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smith, JP1
Drewes, LR1
Phillis, JW1
Ren, J1
O'Regan, MH1
Schurr, A2
Payne, RS2
Miller, JJ2
Tseng, MT2
Rigor, BM1

Other Studies

4 other studies available for alpha-cyano-4-hydroxycinnamate and Brain Ischemia

ArticleYear
Modulation of monocarboxylic acid transporter-1 kinetic function by the cAMP signaling pathway in rat brain endothelial cells.
    The Journal of biological chemistry, 2006, Jan-27, Volume: 281, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Calibration; Colforsin; Coumaric Acids; Cyclic AMP; Cytoplasm; Endot

2006
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
    Journal of neurochemistry, 2001, Volume: 76, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Coumaric Acids; Disease

2001
Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia.
    Brain research, 2001, Mar-23, Volume: 895, Issue:1-2

    Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Carrier Proteins; Coumaric Acids; Energy Metabolism; H

2001
Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental.
    Journal of neuroscience research, 2001, Dec-01, Volume: 66, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Glucose; Brain Ischemia; Corticostero

2001