alpha-chymotrypsin and Tuberculosis

alpha-chymotrypsin has been researched along with Tuberculosis* in 8 studies

Other Studies

8 other study(ies) available for alpha-chymotrypsin and Tuberculosis

ArticleYear
Antigenic epitopes on Mycobacterium tuberculosis recognized by antibodies in tuberculosis and mouse antisera.
    FEMS microbiology immunology, 1991, Volume: 3, Issue:1

    The effect of sodium periodate and proteolytic enzyme treatments on the antibody binding capacity of Mycobacterium tuberculosis antigen (Ag) was studied by ELISA. Treatment with sodium periodate resulted in a marked decrease in the capacity of M. tuberculosis Ag to bind antibodies in human TB sera, but had no effect on the reactivity with antibodies in mouse. In contrast, treatment with proteolytic enzymes (trypsin and chymotrypsin) had no effect on the reactivity of M. tuberculosis Ag with human TB sera but reduced substantially the reactivity to antibodies in mouse antisera. These results indicate that anti-M. tuberculosis antibodies in human TB sera react predominantly with carbohydrate determinants and not with protein epitopes sensitive to trypsin and chymotrypsin. The bulk of murine antibodies on the other hand were directed against protein determinants and not the carbohydrate epitopes.

    Topics: Animals; Antibodies, Bacterial; Antigen-Antibody Reactions; Antigens, Bacterial; Bacterial Proteins; Carbohydrates; Chymotrypsin; Enzyme-Linked Immunosorbent Assay; Epitopes; Immune Sera; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mycobacterium tuberculosis; Periodic Acid; Sonication; Trypsin; Tuberculosis

1991
[Substantiation of the use of pepsidil in secretory insufficiency of the digestive glands caused by antitubercular drugs].
    Problemy tuberkuleza, 1990, Issue:1

    The experiments on rats were undertaken to study the action of pepsidil to make up for the biosynthesis deficiency of digestive enzymes in the stomach and pancreas caused by antituberculous drugs (methazide + PAS, isoniazid + PAS, isoniazid + rifampicin + ethambutol). It was proved that pepsidil reduced an inhibiting action of antituberculous drugs on the activity of gastroenteric tract proteinases. The given condition should be taken into account when antituberculous treatment is conducted.

    Topics: Animals; Antitubercular Agents; Chymotrypsin; Drug Evaluation, Preclinical; Endopeptidases; Enzyme Induction; Enzyme Inhibitors; Gastric Mucosa; Pancreas; Pepsin A; Rats; Trypsin; Trypsin Inhibitors; Tuberculosis

1990
[Histochemical changes in the internal organs during experiment treatment of tuberculosis with proteolytic enzymes].
    Problemy tuberkuleza, 1972, Volume: 50, Issue:11

    Topics: Alkaline Phosphatase; Animals; Chymotrypsin; DNA; Glycogen; Guinea Pigs; Kidney; Liver; Lung; Mycobacterium bovis; Myocardium; RNA; Spleen; Streptomycin; Sulfhydryl Compounds; Tuberculosis

1972
[ON THE USE OF PROTEOLYTIC ENZYMES IN ASSOCIATION WITH ANTIMYCOBACTERIAL AGENTS IN THE THERAPY OF DISEASES OF THE RESPIRATORY SYSTEM].
    La Rassegna di clinica, terapia e scienze affini, 1964, Volume: 63

    Topics: Anti-Bacterial Agents; Antitubercular Agents; Asthma; Bronchiectasis; Bronchitis; Chloramphenicol; Chlortetracycline; Chymotrypsin; Empyema; Humans; Hydrocortisone; Kanamycin; Oxytetracycline; Penicillins; Peptide Hydrolases; Pleurisy; Pneumonia; Pulmonary Emphysema; Respiratory System; Respiratory Tract Diseases; Tuberculosis; Tuberculosis, Pulmonary

1964
ANAPHYLACTIC REACTION CAUSED BY INTRAMUSCULAR INJECTION OF LYOPHILIZED ALPHA-CHYMOTRYPSIN.
    The British journal of ophthalmology, 1964, Volume: 48

    Topics: Aminophylline; Aminosalicylic Acid; Aminosalicylic Acids; Anaphylaxis; Betamethasone; Chymotrypsin; Drug Hypersensitivity; Drug Therapy; Epinephrine; Eye; Hydrocortisone; Injections, Intramuscular; Isoniazid; Prednisolone; Retinal Hemorrhage; Skin Tests; Toxicology; Tuberculosis; Tuberculosis, Ocular

1964
THE USE OF PROTEOLYTIC ENZYMES IN RESPIRATORY PATHOLOGY.
    The British journal of clinical practice, 1964, Volume: 18

    Topics: Asthma; Bronchitis; Chymotrypsin; Drug Therapy; Emphysema; Heart Failure; Humans; Peptide Hydrolases; Pulmonary Emphysema; Pulmonary Fibrosis; Sputum; Trypsin; Tuberculosis; Tuberculosis, Pulmonary; Viscosity

1964
[PROTEOLYTIC ENZYMES IN THE COMBINED TREATMENT OF PATIENTS WITH TUBERCULOSIS AND SUPPURATIVE DISEASES OF THE LUNG AND PLEURA].
    Klinicheskaia meditsina, 1963, Volume: 41

    Topics: Antitubercular Agents; Chymotrypsin; Drug Therapy; Empyema; Empyema, Tuberculous; Humans; Lung Abscess; Lymph Nodes; Peptide Hydrolases; Pleura; Pneumonectomy; Pulmonary Atelectasis; Radiography, Thoracic; Surgical Wound Infection; Trypsin; Tuberculosis; Tuberculosis, Lymph Node; Tuberculosis, Pulmonary

1963
[Anti-mycobacterial drugs in association with proteolytic enzymes in teh therapy of pulmonary tuberculosis].
    Minerva medica, 1962, Nov-24, Volume: 53

    Topics: Antitubercular Agents; Chymotrypsin; Humans; Peptide Hydrolases; Trypsin; Tuberculosis; Tuberculosis, Pulmonary

1962
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