alpha-chymotrypsin and Thrombophlebitis

Topics: Aged; Ascorbic Acid; Chronic Disease; Chymotrypsin; Diarrhea; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Male; Peptide Hydrolases; Phytosterols; Thrombophlebitis; Trypsin

Topics: Adult; Aged; Animals; Anti-Bacterial Agents; Chymotrypsin; Dogs; Drug Combinations; Heparin; Humans; Hydrocortisone; Leg; Middle Aged; Procaine; Thrombophlebitis

Topics: Adult; Aged; Animals; Anti-Bacterial Agents; Bone and Bones; Chymotrypsin; Dogs; Drug Evaluation; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heparin; Humans; Hydrocortisone; Infusions, Parenteral; Leg; Male; Middle Aged; Procaine; Thrombophlebitis; Time Factors

Therapy for patients with extensive thrombophlebitis is ofter inadequate with available methods. The reluctance of most physicians in private practice to use streptokinase or urokinase is understandable when one considers the cost, hospitalization, length of stay and risks involved. This article discusses a unique and previously unreported mode of drug therapy in these patients, consisting of a combination of drugs designed to combine the antithrombotic and thrombusantipropagating effects of warfarin, the anti-inflammatory effect of trypsin-chymotrypsin enzymes, and the antiplatelet aggregating, antiadhesion, and possible enhanced fibrinolytic effects of aspirin with added buffered protection (Ascriptin A/D). This treatment program has been a safe, efficient, economical, and highly effective one for a very costly, common, and disabling disease. It therefore fulfills the ideal criteria for any form of therapy, provided one is knowledgable of its content, and adheres to its contraindications as well as to the basic application of the drugs involved. It is hoped that further investigations along these lines will continue until an ideal solution is reached. Although this is a preliminary report, this study will continue in its present form, and will be expanded to include a series of patients on the aspirin-enzyme combination without the use of warfarin.

Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Chymotrypsin; Drug Therapy, Combination; Humans; Male; Middle Aged; Phlebography; Thrombophlebitis; Trypsin; Warfarin

Topics: Acute Disease; Adult; Aged; Chronic Disease; Chymotrypsin; Female; Femoral Artery; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Thrombophlebitis; Trypsin

Topics: Adult; Anti-Inflammatory Agents; Chymotrypsin; Drug Combinations; Humans; Middle Aged; Phlebitis; Thrombophlebitis; Trypsin

Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Chymotrypsin; Disease Models, Animal; Esterases; Fibrinolysin; Injections, Intravenous; Injections, Subcutaneous; Jugular Veins; Ligation; Methods; Phlebography; Pyrazoles; Rabbits; Streptokinase; Thrombin; Thrombophlebitis; Thrombosis; Vena Cava, Inferior

Topics: Acute Disease; Adolescent; Adult; Aged; Chymosin; Chymotrypsin; Female; Hemorrhoids; Humans; Male; Middle Aged; Peptide Hydrolases; Thrombophlebitis; Trypsin

Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Chymotrypsin; Female; Heparin; Humans; Leg; Lymphedema; Male; Middle Aged; Thrombophlebitis; Trypsin

Topics: Aged; Chymotrypsin; Deoxyribonucleases; Female; Humans; Leg Ulcer; Male; Middle Aged; Occlusive Dressings; Streptokinase; Thrombophlebitis; Trypsin

Topics: Adult; Chymotrypsin; Female; Humans; Leg; Male; Middle Aged; Streptodornase and Streptokinase; Thrombophlebitis; Trypsin; Varicose Ulcer

Topics: Adult; Chymotrypsin; Edema; Episiotomy; Female; Genital Diseases, Female; Humans; Peptide Hydrolases; Pregnancy; Puerperal Disorders; Thrombophlebitis; Trypsin

Topics: Chymotrypsin; Humans; Thrombophlebitis; Trypsin

Topics: Abscess; Adult; Aged; Asthma; Chymotrypsin; Dermatitis; Female; Humans; Male; Middle Aged; Otitis; Respiratory Tract Infections; Tetracycline; Thrombophlebitis; Trypsin

Topics: Animals; Blood Coagulation; Chymotrypsin; Jugular Veins; Leukocytes; Pressure; Rabbits; Retinal Vessels; Thrombophlebitis; Veins

Topics: Chymotrypsin; Female; Herniorrhaphy; Humans; Thrombophlebitis; Vaginal Diseases

Topics: Administration, Cutaneous; Chymotrypsin; Female; Heparin; Humans; Ointments; Pregnancy; Thrombophlebitis; Varicose Veins; Vascular Diseases

Topics: Anticoagulants; Blood Circulation; Chymotrypsin; Humans; Phlebitis; Thrombophlebitis; Varicose Veins; Vascular Diseases; Vascular Surgical Procedures

Topics: Chymotrypsin; Enzyme Therapy; Episiotomy; Female; Gynecology; Humans; Mastitis; Obstetrics; Pelvic Inflammatory Disease; Peritonitis; Pregnancy; Surgical Wound Infection; Thrombophlebitis; Trypsin

Topics: Animals; Breast Diseases; Chymotrypsin; Disease; Episiotomy; Fallopian Tubes; Female; Gynecology; Humans; Obstetrics; Parametritis; Pelvic Inflammatory Disease; Peritonitis; Postoperative Complications; Pregnancy; Puerperal Disorders; Thrombophlebitis

Topics: Chymotrypsin; Edema; Humans; Inflammation; Postoperative Complications; Rifamycins; Suppuration; Surgical Wound Infection; Thrombophlebitis; Trypsin

Topics: Chymotrypsin; Hematologic Tests; Humans; Rectum; Thrombophlebitis

Topics: Chymotrypsin; Gynecology; Hematologic Tests; Humans; Injections, Intramuscular; Thrombophlebitis; Trypsin