alpha-chymotrypsin and Retinal-Detachment

Injection of 150, 500, or 750 U of alpha chymotrypsin into the posterior chamber of clinically normal Beagles resulted in changes in intraocular pressure and iridocyclitis. In the 6 eyes treated with 500 or 750 U, lens subluxation occurred in 4 eyes, retinal detachment in 1 eye, retinal degeneration in 1 eye, and optic nerve degeneration in 6 eyes. Scanning electron microscopic changes included dose-related zonulolysis and zonulary remnants within the aqueous humor outflow pathways. Ultrastructural changes by transmission microscopy of the optic nerve degeneration revealed loss of axoplasm and organelles and disruption of the myelin sheaths. Retinal and optic nerve changes may represent the direct toxic effects of alpha chymotrypsin and/or the indirect effects of increased intraocular pressure.

Topics: Animals; Chymotrypsin; Dog Diseases; Dogs; Eye; Eye Diseases; Intraocular Pressure; Lens Subluxation; Microscopy, Electron; Nerve Degeneration; Ocular Physiological Phenomena; Optic Nerve; Optic Nerve Diseases; Retinal Degeneration; Retinal Detachment; Uveitis, Anterior

Some premises on the clinical aspects of retinal detachment in patients operated upon for cataract and in conditions of lens dislocation are made. The different aspects of the preoperative prophylaxis (indications, techniques, application time) are dealt with, and the technical procedures used during operation for cataract are described. The authors point out the necessity of a postoperative control of the aphakic eyes, at short-or long-term in order to avoid vitreo retinal alterations.

Topics: Cataract Extraction; Chymotrypsin; Humans; Postoperative Complications; Retinal Degeneration; Retinal Detachment; Uveitis

The incidence of aphakia in our series of retinal detachment is 14.82%. The incidence of retinal detachment in aphakia is 2.74%. The use of alpha-chymotrypsin does not influence this incidence. In our own patients, we did not find a sex predominance, although there was a predominance of the male sex in the referred group. The mean age of the patients affected by aphakic retinal detachment was 65.87 years and 82.6% of the cases occurred above the age of 56 years. There was no statistical significant difference between the right and the left eye involvement. Finally, 38.37% of the detachments appeared during the first year after the cataract extraction, 24.4% were myopic and 14.66% bilateral.

Topics: Adult; Age Factors; Aged; Cataract Extraction; Chymotrypsin; Female; Humans; Male; Middle Aged; Refraction, Ocular; Retinal Detachment; Sex Factors; Time Factors

Topics: Animals; Chymotrypsin; Glycosaminoglycans; Hyaluronoglucosaminidase; Lyases; Lysosomes; Rats; Retina; Retinal Detachment

Topics: Cataract Extraction; Chymotrypsin; Humans; Methods; Retinal Detachment; Time Factors

Topics: Animals; Cataract Extraction; Chymotrypsin; Fibrinolytic Agents; Methods; Peptide Hydrolases; Rabbits; Retinal Detachment; Uveitis; Vitreous Body; Wound Healing

Topics: Cataract Extraction; Chymotrypsin; Postoperative Complications; Retinal Detachment

Topics: Cataract Extraction; Chymotrypsin; Humans; Postoperative Complications; Retinal Detachment

Topics: Adolescent; Adult; Aged; Cataract Extraction; Chymotrypsin; Electrocoagulation; Female; Humans; Light Coagulation; Male; Middle Aged; Myopia; Retinal Detachment; Sclera; Time Factors

Topics: Anesthesia, Spinal; Anti-Bacterial Agents; Antineoplastic Agents; Antiviral Agents; Argyria; Blindness; Chymotrypsin; Conjunctivitis; Cortisone; Drug Eruptions; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Epinephrine; Eye Diseases; Glaucoma; Humans; Intraocular Pressure; Lacrimal Duct Obstruction; Miotics; Mydriatics; Ophthalmic Solutions; Optic Neuritis; Retinal Detachment; Vasoconstrictor Agents

Topics: Cataract Extraction; Chymotrypsin; Cryosurgery; Eye Injuries; Humans; Methods; Postoperative Complications; Retinal Detachment; Vision, Ocular; Vitreous Body

Topics: Cataract Extraction; Chymotrypsin; Female; Germany, East; Humans; Male; Methods; Postoperative Complications; Retinal Detachment

Topics: Aged; Anterior Chamber; Aqueous Humor; Cataract Extraction; Chymotrypsin; Corneal Dystrophies, Hereditary; Eye Diseases; Female; Glaucoma; Humans; Hyphema; Iris; Keratitis; Penicillin G; Postoperative Complications; Retinal Detachment; Therapeutic Irrigation

Topics: Cataract Extraction; Chymotrypsin; Humans; Male; Middle Aged; Retinal Detachment

Topics: Atropine; Cataract Extraction; Chymotrypsin; Geriatrics; Glaucoma; Humans; Lidocaine; Ophthalmology; Postoperative Care; Retinal Detachment; Toxicology

Topics: Cataract Extraction; Chymotrypsin; Geriatrics; Humans; Postoperative Complications; Retinal Detachment; Retinal Hemorrhage; Statistics as Topic; Vision, Ocular

Topics: Cataract Extraction; Chymotrypsin; Humans; Pathology; Retinal Detachment; Vitreous Body; Vitreous Detachment