alpha-chymotrypsin and Prostatic-Diseases

We report our initial clinical experience with local transrectal application of enzymatic treatment for chronic nonbacterial prostatitis and prostatodynia in 20 patients. Using a specially designed symptom score for evaluation of subjective treatment parameters, a statistically significant improvement of symptoms was found in the areas of pain, micturition, and recreational activities. No statistically significant differences were noted in laboratory values before and after treatment. Minimal local side effects were seen in only one patient. A favorable clinical response was noted in 75% of patients, whereas the remaining 25% showed only moderate improvement of symptoms. No patient experienced complete treatment failure.

Topics: Adjuvants, Immunologic; Administration, Rectal; Adult; Aged; Aged, 80 and over; Chronic Disease; Chymotrypsin; Drug Combinations; Humans; Male; Middle Aged; Pain; Pain Measurement; Pancreatic Extracts; Papain; Prostatic Diseases; Prostatitis; Retrospective Studies; Thymus Extracts; Treatment Outcome; Trypsin