alpha-chymotrypsin and Leukoplakia--Oral

alpha-chymotrypsin has been researched along with Leukoplakia--Oral* in 2 studies

Trials

1 trial(s) available for alpha-chymotrypsin and Leukoplakia--Oral

Article	Year
Single-dose administration of Bowman-Birk inhibitor concentrate in patients with oral leukoplakia. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:1 The Bowman-Birk inhibitor (BBI) is a soybean-derived serine protease inhibitor and a potential cancer chemopreventive agent for humans. In this Phase I clinical trial, BBI concentrate was administered as a single oral dose to 24 subjects with oral leukoplakia. Pharmacokinetics of BBI was analyzed, and subjects were monitored clinically for toxic effects. Subjects received between 25 and 800 chymotrypsin inhibitor units (CIU) of the compound in a dose escalation trial. BBI was taken up rapidly, and a metabolic product of BBI was excreted in the urine within 24-48 h. No clinical or laboratory evidence of toxicity was observed in the study. Protease activity was also measured in buccal cells to evaluate usefulness as a biomarker. Single-dose BBI concentrate administered up to 800 CIU was well tolerated and appeared to be nontoxic. Further investigation in Phase II clinical trials is being done. Topics: Administration, Oral; Aged; Anticarcinogenic Agents; Biomarkers; Chemoprevention; Chymotrypsin; Endopeptidases; Female; Follow-Up Studies; Humans; Leukoplakia, Oral; Male; Middle Aged; Mouth Mucosa; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors	2000

Article

Year

Single-dose administration of Bowman-Birk inhibitor concentrate in patients with oral leukoplakia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:1

The Bowman-Birk inhibitor (BBI) is a soybean-derived serine protease inhibitor and a potential cancer chemopreventive agent for humans. In this Phase I clinical trial, BBI concentrate was administered as a single oral dose to 24 subjects with oral leukoplakia. Pharmacokinetics of BBI was analyzed, and subjects were monitored clinically for toxic effects. Subjects received between 25 and 800 chymotrypsin inhibitor units (CIU) of the compound in a dose escalation trial. BBI was taken up rapidly, and a metabolic product of BBI was excreted in the urine within 24-48 h. No clinical or laboratory evidence of toxicity was observed in the study. Protease activity was also measured in buccal cells to evaluate usefulness as a biomarker. Single-dose BBI concentrate administered up to 800 CIU was well tolerated and appeared to be nontoxic. Further investigation in Phase II clinical trials is being done.

Topics: Administration, Oral; Aged; Anticarcinogenic Agents; Biomarkers; Chemoprevention; Chymotrypsin; Endopeptidases; Female; Follow-Up Studies; Humans; Leukoplakia, Oral; Male; Middle Aged; Mouth Mucosa; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors

2000

Other Studies

1 other study(ies) available for alpha-chymotrypsin and Leukoplakia--Oral

Article	Year
[Treatment of oral leukoplakia using drug iontophoresis]. Actualites odonto-stomatologiques, 1987, Volume: 41, Issue:158 Topics: Ascorbic Acid; Chymotrypsin; Female; Humans; Hydrocortisone; Iontophoresis; Leukoplakia, Oral; Male	1987