alpha-chymotrypsin and Leg-Ulcer

alpha-chymotrypsin has been researched along with Leg-Ulcer* in 8 studies

Reviews

1 review(s) available for alpha-chymotrypsin and Leg-Ulcer

Article	Year
[Enzyme therapy of trophic ulcers]. Sovetskaia meditsina, 1970, Volume: 33, Issue:3 Topics: Animals; Burns; Chronic Disease; Chymotrypsin; Diabetic Angiopathies; Gangrene; Humans; Injections, Intramuscular; Injections, Intravenous; Leg Ulcer; Peptide Hydrolases; Preoperative Care; Skin Ulcer; Trypsin	1970

Trials

2 trial(s) available for alpha-chymotrypsin and Leg-Ulcer

Article	Year
Crab collagenase in wound debridement. Journal of wound care, 1997, Volume: 6, Issue:1 A comparative study was performed of the caseinolytic, necrolytic and fibrinolytic activities of a crab collagenase product prepared from the hepatopancreas of the king crab (Paralithodes camtschatica) and four enzyme preparations (trypsin/chymotrypsin and protease complexes isolated from Aspergillus terricola, Carica papaya and pseudomonodaceae). This paper reports an in vitro investigation, an in vivo study with rats and a clinical evaluation. It was found that crab collagenase has the highest proteolytic activity measured with respect to fibrin clot and necrotic eschar in vitro although its caseinolytic activity is the lowest. A clinical trial involving 21 patients with leg ulcers confirmed the clinical efficiency of crab collagenase compared with trypsin/ chymotrypsin. The results suggest that crab collagenase is useful in wound debridement. Topics: Aged; Animals; Brachyura; Chymotrypsin; Collagenases; Debridement; Drug Evaluation, Preclinical; Endopeptidases; Female; Humans; Leg Ulcer; Male; Middle Aged; Necrosis; Rats; Rats, Wistar; Trypsin; Wound Healing	1997
The use of topical proteolytic enzymes in the treatment of post-thrombotic leg ulcers. The British journal of clinical practice, 1975, Volume: 29, Issue:6 Topics: Adult; Aged; Anti-Bacterial Agents; Chymotrypsin; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Leg Ulcer; Male; Middle Aged; Placebos; Thrombosis; Trypsin	1975

Article

Year

Crab collagenase in wound debridement.

Journal of wound care, 1997, Volume: 6, Issue:1

A comparative study was performed of the caseinolytic, necrolytic and fibrinolytic activities of a crab collagenase product prepared from the hepatopancreas of the king crab (Paralithodes camtschatica) and four enzyme preparations (trypsin/chymotrypsin and protease complexes isolated from Aspergillus terricola, Carica papaya and pseudomonodaceae). This paper reports an in vitro investigation, an in vivo study with rats and a clinical evaluation. It was found that crab collagenase has the highest proteolytic activity measured with respect to fibrin clot and necrotic eschar in vitro although its caseinolytic activity is the lowest. A clinical trial involving 21 patients with leg ulcers confirmed the clinical efficiency of crab collagenase compared with trypsin/ chymotrypsin. The results suggest that crab collagenase is useful in wound debridement.

Topics: Aged; Animals; Brachyura; Chymotrypsin; Collagenases; Debridement; Drug Evaluation, Preclinical; Endopeptidases; Female; Humans; Leg Ulcer; Male; Middle Aged; Necrosis; Rats; Rats, Wistar; Trypsin; Wound Healing

1997

The use of topical proteolytic enzymes in the treatment of post-thrombotic leg ulcers.

The British journal of clinical practice, 1975, Volume: 29, Issue:6

Topics: Adult; Aged; Anti-Bacterial Agents; Chymotrypsin; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Leg Ulcer; Male; Middle Aged; Placebos; Thrombosis; Trypsin

1975

Other Studies

5 other study(ies) available for alpha-chymotrypsin and Leg-Ulcer

Article	Year
Chymocell--a new wound cleansing agent. Sbornik lekarsky, 1997, Volume: 98, Issue:3 A new wound cleansing agent consisting of bead cellulose with covalently, firmly bound proteolytic enzyme, chymotrypsin, was prepared. It was found that this preparation can be applied in the treatment of suppurating wounds of all types with very good results. Topics: Cellulose; Chymotrypsin; Humans; Leg Ulcer; Powders; Suppuration; Wounds and Injuries	1997
[Occlusive dressings and their significance in the complex treatment of trophic ulcers]. Klinicheskaia khirurgiia, 1971, Volume: 9 Topics: Aged; Chymotrypsin; Deoxyribonucleases; Female; Humans; Leg Ulcer; Male; Middle Aged; Occlusive Dressings; Streptokinase; Thrombophlebitis; Trypsin	1971
[Use of proteolytic enzymes of animal origin in ambulatory surgery]. Vestnik khirurgii imeni I. I. Grekova, 1970, Volume: 105, Issue:11 Topics: Adolescent; Adult; Aged; Ambulatory Care; Burns; Carbuncle; Chymotrypsin; Female; Furunculosis; Humans; Leg Ulcer; Male; Middle Aged; Minor Surgical Procedures; Paronychia; Peptide Hydrolases; Wound Infection	1970
[ALPHA-CHYMOTRYPSIN-FRAMYCETIN ASSOCIATION IN EXTERNAL THERAPY (LEG ULCERS AND DIVERSE APPLICATIONS)]. Gazette medicale de France, 1964, Nov-10, Volume: 71 Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chymotrypsin; Dermatologic Agents; Drug Therapy; Framycetin; Geriatrics; Leg Ulcer; Toxicology	1964
[ON THE UTILIZATION OF ORAL TRYPSIN AND CHYMOTRYPSIN. CLINICAL EVALUATION]. Minerva medica, 1964, Dec-22, Volume: 55 Topics: Burns; Chymotrypsin; Drug Therapy; Foot Diseases; Gangrene; Humans; Leg Ulcer; Pressure Ulcer; Trypsin	1964