alpha-chymotrypsin and Histiocytoma--Malignant-Fibrous

Primary malignant fibrous histiocytoma (MFH) of the liver remains extremely rare with only several cases having been reported in literature. We report a case of hepatic MFH in a 53-year-old man who presented with upper abdominal pain, and weight loss for one month. Ultrasound and computed tomography (CT) scan showed a large mass with fine tumor vessels over the left lobe of the liver. Histopathological findings indicated a mesenchymal tumor consisting of spindle cells in storiform pattern intermingled with histiocyte-like cells and giant cells. Immunohistochemically, most tumor cells expressed vimentin, alpha-1 anti-chymotrypsin, alpha-1 antitrypsin and CD68. Morphological and immunohistochemical findings support that the tumor should be classified as a primary malignant fibrous histiocytoma. The literatures is briefly reviewed.

Topics: alpha 1-Antitrypsin; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Chymotrypsin; Fatal Outcome; Hepatitis; Histiocytoma, Malignant Fibrous; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Male; Middle Aged; Recurrence; Tomography, X-Ray Computed; Vimentin